scholarly journals Experimental Tumor

2020 ◽  
Author(s):  
Keyword(s):  
Experimental Tumor

Application of Transmission Electron Microscope and Scanning Electron Microscope in experimental tumor studies

1990 ◽  
Vol 48 (3) ◽  
pp. 306-307
Author(s):  
Gao Fengming
Keyword(s):  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Malignant Transformation ◽  
Transmission Electron Microscope ◽  
Experimental Tumor ◽  
Transmission Electron ◽  
Embryo Cells ◽  
Tumor Studies ◽  
Scanning Electron

Transmission electron microscope(TEM) and scanning electron microscope(SEM) were widely used in experimental tumor studies. They are useful for evaluation of cellular transformation in vitro, classification of histological types of tumors and treating effect of tumors. We have obtained some results as follows:1. Studies on the malignant transformation of mammalian cells in vitro. Syrian golden hamster embryo cells(SGHEC) were transformed in vitro by ThO2 and/or ore dust. In a few days after dust added into medium, some dust crystals were phagocytized. Two weeks later, malignant transformation took place. These cells were of different size, nuclear pleomorphism, numerous ribosomes, increasing of microvilli on cell surface with various length and thickness, and blebs and ruffles(Figs. 1,2). Myelomonocytic leukemic transformation of mouse embryo cells(MEC) was induced in vitro by 3H-TdR. Transformed cells were become round from fusiform. The number of mitochondria and endoplasmic reticulum was reduced, ribosomes and nucleoli increased, shape of nuclei irregular, microvilli increased, and blebs and ruffles appeared(Fig. 3).

Fibrinogen, Platelet and Red Cell Kinetics in Mice Bearing an Experimental Tumor

1975 ◽  
Author(s):  
A. Poggi ◽  
N. Polentarutti ◽  
M. B. Donati ◽  
G. de Gaetano ◽  
S. Garattini
Keyword(s):  
Cell Kinetics ◽  
Fibrinogen Level ◽  
Low Grade ◽  
Red Cell ◽  
Experimental Tumor ◽  
Tumor Implantation ◽  
The Third ◽  
Red Cell Survival ◽  
Observation Period

In view of the possible role of platelets and coagulation mechanisms in the growth and dissemination of solid tumors, a number of haematological parameters have been followed during development of an experimental syngeneic tumor in mice (Lewis Lung Carcinoma, 3LL). This tumor, when transplanted intramuscularly in C57,B1/6 mice, grows locally and gives spontaneous metastases to the lungs. The transplanted animals survive for about 4 weeks. Metastases are visible since the third week. A slight but constant increase in plasma fibrinogen level and a marked thrombocytopenia were observed starting during the second week after tumor implantation. No other significant changes in coagulation and fibrinolysis parameters were found. Moreover, the animals developed a marked haemolytic anaemia, possibly microangiopathic in origin. 125I-fibrinogen survival was decreased of about 20% during the second week after tumor implantation and was not further reduced later on. Fibrinogen turnover was accelerated since the second week and was further increased thereafter, being more than doubled at the end of the third week. Labelled fibrinogen accumulated in the primary tumor and in the lungs; its rats of disappearance from the tumor was much slower than from lungs or blood. These data suggest the occurrence of a low-grade, localized fibrinogen consumption (intravascular coagulation ?). 51Cr-platelet survival was not modified throughout the observation period, whereas platelet turnover was markedly reduced since the end of the second week, suggesting a defective platelet production. 51Cr-red cell survival was drastically reduced to about 30% of controls starting from the second week, whereas labelled red cell turnover was almost doubled. The pathogenetic relevance of the observed modifications in the processes of grwoth and dissemination of 3 LL remains to be established.(Supported by Grant NIH-PHRB-IRO1 CA 12764–01.

Therapy and prophylaxis of experimental tumor induced bone lesions by bisphosphonic acid (APD) in the rat

1986 ◽  
Vol 111 (S1) ◽  
pp. S50-S50
Author(s):  
Th. Eichmann ◽  
F. Wingen ◽  
D. Schmähl ◽  
B. Krempien
Keyword(s):  
Bone Lesions ◽  
Experimental Tumor ◽  
Bisphosphonic Acid

Systemic IL-1 and adjuvant treatment of an experimental tumor

Biotherapy ◽  
1992 ◽  
Vol 5 (4) ◽  
pp. 259-274 ◽  
Author(s):  
Sylvia M. Kiertscher ◽  
Herbert L. Mathews
Keyword(s):  
Adjuvant Treatment ◽  
Experimental Tumor

The Effect of Selected Antibiotics on the Endogenous Intestinal Microflora and its Consequences for Experimental Tumor Growth in BALB/C Mice

1986 ◽  
pp. 459-463
Author(s):  
K. Roszkowski ◽  
H. L. Ko ◽  
D. van der Waaij ◽  
W. Roszkowski ◽  
J. Jeljaszewicz ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Intestinal Microflora ◽  
Experimental Tumor

The Effect of Interferon on Experimental Tumor Metastases

1989 ◽  
pp. 171-180 ◽  
Author(s):  
I. Gresser
Keyword(s):  
Experimental Tumor ◽  
Tumor Metastases
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