CLINICAL PROFILE OF OCULAR SURFACE SQUAMOUS NEOPLASIA (OSSN).

Aim: To Study the Clinical profile of Ocular Surface Squamous Neoplasia (OSSN). Design: Retrospective study. Materials and Methods: We analysed 28 cases of OSSN who presented to the out-patient department of tertiary eye care centre Hospital, over a period of 1 year from January 2017 to January 2018. Results: In patients, who presented with OSSN age ranged from 24 to 70 years, mean age being 44.80 years. Males were predominantly affected accounting for 64.28%. A nodule at the libus is the commonest presentation. About 25% of the patients were positive for HIV with mean age of presentation 32 years. Among HIV positive patients 5 cases had SCC. Conclusion: OSSN was observed more common in males. Nodular type of lesion is the commonest variety. HIV positive individuals have an increased incidence of OSSN with invasive characteristics. Hence, ophthalmologists need to be aware of this association and a thorough workup is warranted for all patients presenting with OSSN, especially in the younger age group. Keywords: Ocular surface squamous neoplasia, Carcinoma in-situ(CIS), Squamous cell carcinoma (SCC)

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Clinico-Pathological Study of Ocular Surface Squamous Neoplasia in a Tertiary Care Centre of Western Region of Nepal

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v7i1.24677 ◽

2019 ◽

Vol 7 (1) ◽

pp. 9-13

Author(s):

Sushila Patel ◽

Binita Bhattarai Pokharel ◽

Anita Shah ◽

Manita Sunam Goda ◽

Saraswati Khadka Thapa

Keyword(s):

Ocular Surface ◽

Histopathological Examination ◽

Tertiary Care ◽

Western Region ◽

Invasive Squamous Cell Carcinoma ◽

Care Centre ◽

Ocular Surface Squamous Neoplasia ◽

Tertiary Care Centre ◽

Male Predominance ◽

Wide Range

INTRODUCTION: Ocular surface squamous neoplasia (OSSN) consists of a wide range of conjunctival and corneal lesions ranging from dysplastic lesions to invasive squamous cell carcinoma. In recent times, the incidence of OSSN seems to be on the rise, especially in developing countries. The present study was aimed to analyse demographic pattern, clinical characteristics, and histopathology findings of OSSN in a tertiary care centre of western region of Nepal. MATERIAL AND METHODS: It was a retrospective study. We analyzed 94 cases of OSSN who presented to cornea department of Lumbini Eye Institute, Bhairahawa, Nepal over a period 1.5 years from 1st July 2017 to 31st December 2018. All the patients with OSSN, detailed clinical history and examination were recorded. Lesions were excised with a 3 mm margin clearance and sent for histopathological examination. RESULTS: Mean age of our patients with OSSN was 48.89±17.955 years ranging from 17 to 85 years. There were 52 (55.32%) male and 42 (44.68%) female. Mean duration of presentation was 6.34±6.17 months. A solitary nodule at the limbus was the commonest presentation. Right eyes were involved more than left eyes. Lesions were found most commonly on temporal site 52 (55.32%) followed by nasal 36 (38.30%). On histopathological examination benign lesions were found in 31 (32.98%) eyes, preinvasive lesion in 50 (53.19%) eyes and invasive lesions in 13 (13.83%) eyes. CONCLUSION: OSSN were seen more commonly in young adults with male predominance. Benign and pre invasive lesions are found more commonly than invasive lesions.

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CLINICAL PROFILE OF INTUSSUSCEPTION IN CHILDREN ADMITTED TO A TERTIARY CARE CENTRE IN KERALA

International Journal of Medical Science and Diagnosis Research ◽

10.32553/ijmsdr.v4i12.726 ◽

2020 ◽

Vol 4 (12) ◽

Author(s):

Neethu Jose ◽

Aparna Namboodiripad ◽

Regi George A N

Keyword(s):

Tertiary Care ◽

Spontaneous Resolution ◽

Reduction Technique ◽

Clinical Profile ◽

Age Group ◽

Care Centre ◽

Tertiary Care Centre ◽

Hydrostatic Reduction ◽

Duration Of Hospital Stay ◽

Study Population

Background and objectives: Intussusception is the commonest cause of bowel obstruction and is one of the common abdominal emergencies in children younger than 2 years of age.The objective of the study was to assess the clinical profile of intussusception in children and the management and the outcome and to assess whether the characteristics mentioned in clinical profile are predictive of subsequent management and outcome of the disease. Methods: A hospital based descriptive study conducted in a tertiary care centre in Kerala, using purposive sampling technique. 120 children admitted with diagnosis of intussusception fulfilling inclusion criteria and whose parents consented for study were included in the study population, during the study period from November 2018 to June 2020. Detailed history, clinical examination including per rectal examination and USG was done to make diagnosis of intussusception in suspected cases. Follow up is done at 72 hours,1 week after the admission and 1month later. To assess the clinical profile and outcome of patients, frequency and percentage is used. To obtain the association of clinical profile with outcome chi square test is applied. Results: Outcome of the problem was correlated with age, sex, symptoms, risk factors sonological findings treatment protocol and duration of hospital stay. Out of the 120 children in study population, majority were males(65.8%) with male to female ratio 1.9:1 and majority was in the age group 7- 12 months, which is similar to many other similar studies. Maximum number of cases were in the month of February(14.2%) and November(15%). Majority of the patients(57.5%) presented to healthcare facility within 24 hours of onset of first symptom.Irritability was the most common clinical symptom(62.5%) followed by vomiting(58.3%) and abdominal pain(49.2%). Ileocolic intussusception (96.7%) was the commonest type. Majority of the cases could be managed with hydrostatic saline reduction(73.3%) and significantly lesser number of patient went for surgical intervention(7.5%) and spontaneous resolution(19.2%). Conclusions: Incidence of intussusception is more common among males and more in the 7-12 month age group. Majority of the cases presented to health care facility within 24 hours of onset of symptom and could be managed with hydrostatic reduction technique and had a shorter duration of hospital stay compared to surgical reduction technique. Even recurrent cases could be managed with hydrostatic saline reduction. Keywords: Intussusception; Intestinal obstruction; Hydrostatic reduction; Spontaneous resolution

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Clinical profile of childhood blindness in a tertiary eye care centre in central India

Indian Journal of Clinical and Experimental Ophthalmology ◽

10.18231/2395-1451.2018.0112 ◽

2018 ◽

Vol 4 (4) ◽

pp. 503-506

Author(s):

Jyotsna Jareda ◽

Sooraj Singh Kubrey

Keyword(s):

Central India ◽

Clinical Profile ◽

Care Centre ◽

Eye Care ◽

Childhood Blindness

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Comparison between Optical Coherence Tomography and Fundus Fluorescein Angiography in the Detection of Cystoid Macular Oedema in a Tertiary Eye Care Centre in Nagpur, Maharashtra

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/627 ◽

2021 ◽

Vol 8 (40) ◽

pp. 3459-3463

Author(s):

Kavita Anand Dhabarde ◽

Karuna Radhakishan Painjane ◽

Ashok Hukumchand Madan

Keyword(s):

Optical Coherence Tomography ◽

Retinal Vein Occlusion ◽

Macular Oedema ◽

Cystoid Macular Oedema ◽

Optical Coherence ◽

Age Group ◽

Care Centre ◽

Eye Care ◽

Fundus Fluorescein Angiography ◽

Vein Occlusion

BACKGROUND Fundus fluorescin angiography (FFA) has been traditional gold standard for detection of cystoid macular oedema (CME) but nowadays optical coherence tomography (OCT) is used more often by to detect CME due to various conditions. Although FFA can assess CME qualitatively, OCT provides quantitative measurement of foveal thickness. The purpose of this study is to compare sensitivity of FFA and OCT for detection of CME and know the etiological distribution of CME and the ability of FFA and OCT in diagnosing CME in different aetiologies. METHODS A hospital based prospective observational diagnostic study was conducted in tertiary eye care centre in central India on 143 eyes of 103 patients. FFA and OCT findings in patients of CME diagnosed provisionally on fundus examination were studied. RESULTS Of total 103 patients studied, maximum patients 20 (19.42 %) were in age group of 55 - 59 years whereas minimum 6 (5.83 %) were in age group of 40 - 44 years. In 103 patients, 61 (59.22 %) were males and 42 (40.78 %) were females. Both eyes were involved in 41 (40.78 %) cases. Most common cause of CME was nonproliferative diabetic retinopathy (NPDR) 52 eyes (35.86 %), followed by branch retinal vein occlusion (BRVO) 32 eyes (22.06 %), then proliferative diabetic retinopathy (PDR) 14 eyes (9.6 %), central retinal vein occlusion (CRVO) 13 eyes (8.96 %). CME on OCT was seen in maximum of retinal vein occlusion patients - CRVO (84.61 %) and BRVO (84.37 %). Of 145 eyes, 114 (78.32 %) eyes had CME. CONCLUSIONS Most common cause of CME was NPDR followed by BRVO, PDR and CRVO. Sensitivity of OCT in comparison with FFA was 100 % with diagnostic accuracy of 81.38 %. Hence, one can use OCT as first modality investigation for diagnosis of CME. KEYWORDS Optical Coherence Tomography, Fundus Fluorescein Angiography, Cystoid Macular Oedema, NPDR

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Clinical Profile, Treatment, and Visual Outcome of Ocular Toxocara in a Tertiary Eye Care Centre

Ocular Immunology and Inflammation ◽

10.1080/09273948.2016.1249375 ◽

2016 ◽

Vol 26 (5) ◽

pp. 753-759 ◽

Cited By ~ 1

Author(s):

Ekta S. Sahu ◽

Bikramjit Pal ◽

Tarun Sharma ◽

Jyotirmay Biswas

Keyword(s):

Visual Outcome ◽

Clinical Profile ◽

Care Centre ◽

Eye Care

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Symptomatic Dystonia: Clinical Profile of 46 Brazilian Patients

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100041718 ◽

1992 ◽

Vol 19 (4) ◽

pp. 504-507 ◽

Cited By ~ 17

Author(s):

Henrique B. Ferraz ◽

Luiz Augusto F. Andrade

Keyword(s):

Muscle Contraction ◽

Older Age ◽

Cerebral Injury ◽

Clinical Profile ◽

Age Group ◽

Mitochondrial Cytopathy ◽

Cranial Trauma ◽

Tardive Dystonia ◽

Younger Age ◽

Symptomatic Dystonia

ABSTRACT:Dystonia is a syndrome characterized by sustained muscle contraction, provoking twisting and repeti-tive movements or abnormal postures. It may be classified according to etiology, as idiopathic or symptomatic. We studied 122 Brazilian patients with a dystonic syndrome. Of these, 46 (37.7%) had symptomatic dystonia. The most frequent cause was tardive dystonia (34.8%) followed by perinatal cerebral injury (30.4%). Other causes were stroke (13.0%), encephalitis (6.5%) and Wilson’s disease (4.3%). Cranial trauma, mitochondrial cytopathy and psychogenic, were the least frequent causes with one patient in each category. The etiology in two patients could not be established. Perinatal cerebral injury and postencephalitic dystonia were seen in the younger age group, while post-stroke and tardive dystonia were seen in the older age group.

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