Ocular surface squamous neoplasia in HIV-positive and HIV-negative patients and response to 5-fluorouracil in Angola

Aim: To Study the Clinical profile of Ocular Surface Squamous Neoplasia (OSSN). Design: Retrospective study. Materials and Methods: We analysed 28 cases of OSSN who presented to the out-patient department of tertiary eye care centre Hospital, over a period of 1 year from January 2017 to January 2018. Results: In patients, who presented with OSSN age ranged from 24 to 70 years, mean age being 44.80 years. Males were predominantly affected accounting for 64.28%. A nodule at the libus is the commonest presentation. About 25% of the patients were positive for HIV with mean age of presentation 32 years. Among HIV positive patients 5 cases had SCC. Conclusion: OSSN was observed more common in males. Nodular type of lesion is the commonest variety. HIV positive individuals have an increased incidence of OSSN with invasive characteristics. Hence, ophthalmologists need to be aware of this association and a thorough workup is warranted for all patients presenting with OSSN, especially in the younger age group. Keywords: Ocular surface squamous neoplasia, Carcinoma in-situ(CIS), Squamous cell carcinoma (SCC)

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Management of Ocular Surface Squamous Neoplasia in Association with Fungal Keratitis in a HIV Positive Individual

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/46306.14496 ◽

2021 ◽

Author(s):

Prabhakar Singh ◽

Abhishek Gupta ◽

Richa Gupta

Keyword(s):

Risk Factors ◽

Ocular Surface ◽

Comprehensive Evaluation ◽

Topical Steroid ◽

Fungal Keratitis ◽

Hiv Positive ◽

Ocular Surface Squamous Neoplasia ◽

Steroid Abuse ◽

Positive Individual ◽

Vegetative Matter

Ocular Surface Squamous Neoplasia (OSSN) co-existent with fungal keratitis in an immunodeficient individual has rarely been talked about in literature. Risk factors for fungal keratitis are trauma with vegetative matter, topical steroid abuse, poor ocular surface, corneal anaesthesia, systemic immunosuppression, etc., and for OSSN a major risk factor is immunodeficiency. In current report, patient had multiple risk factors. This report highlights the management of HIV positive 42-year-old male with OSSN and fungal keratitis. A comprehensive evaluation helps clinician decide on treatment priority and achieve good clinical outcome.

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Fungal Keratitis and Ocular Surface Squamous Neoplasia in a HIV Positive Patient

Open Journal of Ophthalmology ◽

10.4236/ojoph.2016.62015 ◽

2016 ◽

Vol 06 (02) ◽

pp. 108-111

Author(s):

Thanuja Pradeep ◽

Ramya Marappa

Keyword(s):

Ocular Surface ◽

Fungal Keratitis ◽

Positive Patient ◽

Hiv Positive ◽

Ocular Surface Squamous Neoplasia

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Simultaneous presentation of ocular surface squamous neoplasia with viral retinitis in HIV-positive patients with low CD4 counts

Indian Journal of Ophthalmology ◽

10.4103/ijo.ijo_902_18 ◽

2019 ◽

Vol 67 (1) ◽

pp. 116

Author(s):

Rama Rajagopal ◽

PratikV Kataria ◽

Sudharshan Sridharan ◽

Krishna Kumar ◽

KuzhanthaiLily Therese ◽

...

Keyword(s):

Ocular Surface ◽

Simultaneous Presentation ◽

Hiv Positive ◽

Ocular Surface Squamous Neoplasia ◽

Cd4 Counts

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Clinical behaviour of ocular surface squamous neoplasia (OSSN) in HIV positive patients

MRIMS Journal of Health Sciences ◽

10.4103/2321-7006.302248 ◽

2016 ◽

Vol 4 (2) ◽

pp. 114

Author(s):

P Padmavathi ◽

DPadma Prabha ◽

Mohd. Ather ◽

T Kavitha ◽

M Padma

Keyword(s):

Ocular Surface ◽

Hiv Positive ◽

Ocular Surface Squamous Neoplasia ◽

Clinical Behaviour

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Incidence of Cytological Abnormalities in Pap's Smear in HIV Positive Women

Journal of Medical Research and Innovation ◽

10.15419/jmri.136 ◽

2018 ◽

Vol 2 (S1) ◽

pp. e000136

Author(s):

Suhana Jotva ◽

Hemani Desai ◽

Hansa Goswami

Keyword(s):

Trichomonas Vaginalis ◽

Clinical History ◽

Hiv Positive ◽

Squamous Intraepithelial Lesions ◽

Squamous Cells ◽

Medical College ◽

Hiv Positive Women ◽

Cytological Abnormalities ◽

Intraepithelial Lesions ◽

Hiv Negative

Aims and Objectives: The aim of present study is to estimate the frequency of abnormal PAP’s smears and mainly to detect precancerous and cancerous lesions as well as inflammatory lesions in HIV infected women. Methodology: Our study was a retrospective study of total 130 cases and PAP’s smears were examined in cytology section in Department of Pathology, BJ Medical College, Ahmedabad from 1st March 2017 to 31st August 2017. Both HIV positive and HIV negative patients were included in the study. 80 patients were HIV negative and 50 patients were HIV positive. The clinical history and relevant parameters were noted. All the smears were processed by a conventional method using Papanicolaou stain. Results: Out of 130 cases, 118 cases were reported negative for intraepithelial lesions or malignancy (NILM). Five cases were positive for squamous intraepithelial lesions (SIL) out of which four were HIV positive. Seven cases were of atypical squamous cells of undetermined significance (ASCUS) out of which 5 were HIV positive. Three cases were showing bacterial vaginosis. 1 case was showing Trichomonas Vaginalis. 19 cases were showing changes of non-specific inflammation. 6 cases were showing atrophic changes. Conclusion: HIV infected women are at more risk to develop cervical cytological abnormalities. The study revealed a maximum number of non-specific inflammatory smears followed by smears showing atrophic changes. Smears suspicious for malignancy (ASCUS) and smears showing squamous intraepithelial lesions (SIL) were more common in HIV positive patients. Thus regular PAP’s smears screening as recommended by National AIDS Control Organization (NACO) will help in early detection of cervical abnormalities in HIV positive women.

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