scholarly journals Clinico-Pathological Study of Ocular Surface Squamous Neoplasia in a Tertiary Care Centre of Western Region of Nepal

2019 ◽  
Vol 7 (1) ◽  
pp. 9-13
Author(s):  
Sushila Patel ◽  
Binita Bhattarai Pokharel ◽  
Anita Shah ◽  
Manita Sunam Goda ◽  
Saraswati Khadka Thapa
Keyword(s):  
Ocular Surface ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Western Region ◽  
Invasive Squamous Cell Carcinoma ◽  
Care Centre ◽  
Ocular Surface Squamous Neoplasia ◽  
Tertiary Care Centre ◽  
Male Predominance ◽  
Wide Range

INTRODUCTION: Ocular surface squamous neoplasia (OSSN) consists of a wide range of conjunctival and corneal lesions ranging from dysplastic lesions to invasive squamous cell carcinoma. In recent times, the incidence of OSSN seems to be on the rise, especially in developing countries. The present study was aimed to analyse demographic pattern, clinical characteristics, and histopathology findings of OSSN in a tertiary care centre of western region of Nepal.  MATERIAL AND METHODS: It was a retrospective study. We analyzed 94 cases of OSSN who presented to cornea department of Lumbini Eye Institute, Bhairahawa, Nepal over a period 1.5 years from 1st July 2017 to 31st December 2018. All the patients with OSSN, detailed clinical history and examination were recorded. Lesions were excised with a 3 mm margin clearance and sent for histopathological examination.  RESULTS: Mean age of our patients with OSSN was 48.89±17.955 years ranging from 17 to 85 years. There were 52 (55.32%) male and 42 (44.68%) female. Mean duration of presentation was 6.34±6.17 months. A solitary nodule at the limbus was the commonest presentation. Right eyes were involved more than left eyes. Lesions were found most commonly on temporal site 52 (55.32%) followed by nasal 36 (38.30%). On histopathological examination benign lesions were found in 31 (32.98%) eyes, preinvasive lesion in 50 (53.19%) eyes and invasive lesions in 13 (13.83%) eyes.  CONCLUSION: OSSN were seen more commonly in young adults with male predominance. Benign and pre invasive lesions are found more commonly than invasive lesions.

Histopathological Study of Lesions of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in a Tertiary Care Centre, Visakhapatnam over a Period of 2 Years

2021 ◽  
Vol 8 (33) ◽  
pp. 3054-3059
Author(s):  
Rajendra Prasad Jagannadham ◽  
Lakshmi Latchupatula ◽  
Sravani Ponnada ◽  
Neelima Lalam ◽  
Raghunadhababu Gudipudi ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Malignant Tumours ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Male Predominance

BACKGROUND A variety of non - neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasopharynx and these are very common lesions encountered in clinical practice. Histopathological examination of these lesions is the gold standard for diagnosis because management and prognosis vary among different lesions. The aim of the present study was to evaluate the histopathological study of the lesions of the nasal cavity, paranasal sinuses and nasopharynx in relation to their incidence, age, gender and site wise distribution and to compare the results with the available data. METHODS A study of 88 cases was conducted for a period of 2 years from August 2017 to July 2019. After fixation, Processing and Haematoxylin and Eosin staining and special stains histopathological diagnosis was made. RESULTS Among 88 total cases, 58 were males and 30 were females. A male predominance was observed with a male to female ratio of 1.93 : 1. They were more common in third, fourth and fifth decade of life. Malignant nasal lesions were seen after fourth decade of life. Nasal lesions were more common in nasal cavity (67.05 %), followed by paranasal sinuses (18.18 %) and nasopharynx (14.75). Out of 88 total cases, 39 (44.32 %) were non - neoplastic, 30 (34.09 %) were benign and 19 (21.59 %) were malignant nasal lesions. CONCLUSIONS Sinonasal lesions and nasopharyngeal lesions can have various differential diagnoses. A complete clinical, radiological and histopathological correlation helps to categorize these sinonasal lesions into various non - neoplastic and neoplastic types. But histopathological examination remains the mainstay of definitive diagnosis. KEYWORDS Nasal Cavity, Paranasal Sinuses, Nasopharynx, Benign Tumours, Malignant Tumours, Histopathological Examination

A CLINICOPATHOLOGICAL STUDY ON DISSEMINATED HISTOPLASMOSIS WITH SPECIAL REFERENCE TO ATYPICAL CASES IN A TERTIARY CARE CENTRE -IN EASTERN INDIA.

2021 ◽  
pp. 48-51
Author(s):  
Anuradha De (Pati) ◽  
Roopsa Chakraborty ◽  
Bibhuti Saha
Keyword(s):  
Histoplasma Capsulatum ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Cd4 Count ◽  
Yeast Cells ◽  
Steady Increase ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Disseminated Histoplasmosis ◽  
India Ink

INTRODUCTION: Untreated Histoplasmosis is fatal for all, immunocompetent or immunocompromised. Histoplasmosis has seen a steady increase in incidence from a single recorded case in Kolkata, India in 1954 to 388 cases from 2004-17 and 161 from 2017-till date all over India. Yet, it has been consistently relegated to a niche of opportunistic infections without a proper diagnostic protocol. To study the clinical OBJECTIVES: features and natural history of disseminated histoplasmosis(DH) and analysis of cases with atypical clinical presentation of Histoplasmosis simulating malignancy in search of a consolidated and efcient diagnostic algorithm in a tertiary care centre. MATERIALS AND METHODS: The retrospective institution-based study was conducted in the Department of Pathology, CSTM from February 2011 to July 2019 in collaboration of Dept. of Tropical Medicine on specimens collected from 33 cases of Skin biopsy, Lymph node biopsy and FNAC aspirate from enlarged lymphnodes, slit skin smear followed by BM Aspirate analysis done in cases of disseminated histoplasmosis, Bone Marrow Biopsy was done in selected cases. Histoplasma capsulatum like yeast cells were detected with Leishman Giemsa stained slit skin smears in 9 cases and in FNA smears in 13cases and they were PAS positive. Diagnosis were conrmed in Histopathological examination along with special stain for fungus in all cases. Radiological investigations (CXR, USG, CT), Routine investigations (Haemogram, LFT, RFT, Electrolytes) along with CD4 count in ART clinic and microbiological tests like Gram stain of SSS, India Ink, KOH preparation, Cryptococcal Ag testing, urine C/S) were corroborated with. RESULTS: All 33 cases FNAC (13),slit skin smear(9) and HPE on rest of the specimen show small, oval yeast cells on LG stain. Biopsy showed histiocytic phagocytosis of yeast cells with foamy macrophages and PMN inltration with NO granulomas in seroposive cases. Gomori Methenamine Silver stain of BM biopsy showed black intracellular yeast consistent with . PAS stained FNAC smears Histoplasma capsulatum showed yeast cells with chromatin dot and surrounding halos with no kinetoplasts. Mycological cultures were in agreement. Here, in most cases, CD4 count and Disseminated Histoplasmosis ndings were not in accordance. DH CONCLUSION: is not uncommon in India and is being increasing day by day and it should be considered in the diagnosis of patients with prolonged fever, weight loss, oropharyngeal ulcers, hepatosplenomegaly, lymphadenopathy and adrenal enlargement. Correct diagnosis by well designed analytical studies utilising appropriate diagnostic modalities in an immunocompromised patient even with minimum suspicion of opportunistic infection, a consolidation of selective investigations like FNAC, HPE and relevant microbiological tests into a diagnostic design for maximum utilization of nances, resources and time, all of which can help to understand the epidemiology of this neglected disease for accurate treatment leading to a favourable outcome.

scholarly journals Successful Vaginal delivery of locked twin in a tertiary care centre of Western region of Nepal

2014 ◽  
Vol 3 (1) ◽  
pp. 74-75 ◽  
Author(s):  
MR Pandey ◽  
P Ghimire ◽  
P Ghimire
Keyword(s):  
Vaginal Delivery ◽  
Twin Pregnancy ◽  
Tertiary Care ◽  
Labor Pain ◽  
Western Region ◽  
Care Centre ◽  
Medical Sciences ◽  
Tertiary Care Centre ◽  
Mediolateral Episiotomy

Here we report a case of unbooked primigravida who was admitted to the labor room with labor pain. Ultrasonography revealed twin pregnancy with first twin presenting as breech. After coming head of the first breech fetus locked with the head of the second cephalic fetus during labor. Successful Vaginal delivery of both the live fetuses was performed along with mediolateral episiotomy following disengagement of head. Nepal Journal of Medical Sciences | Volume 03 | Number 01 | January-June 2014 | Page 74-75 DOI: http://dx.doi.org/10.3126/njms.v3i1.10366

scholarly journals Clinicopathological profile of sinonasal masses-a tertiary care centre study in rural India

2020 ◽  
Vol 6 (10) ◽  
pp. 1821
Author(s):  
Vidya Rokade ◽  
Kiran J. Shinde ◽  
Girishkumar R. More
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Rural India ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Radiological Investigation ◽  
Male Predominance ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

<p><strong>Background:</strong> A variety of mass lesions occur within the paranasal sinus (PNS) and nasal cavity and thus it becomes mandatory for otorhinolaryngologist to elicit detailed history and thorough examination before reaching a final diagnosis. This is retrospective study of all sinonasal masses who were undergone surgical management in the institute of rural India and so in the environment.</p><p><strong>Methods:</strong> This is a retrospective observational study of 70 patients with sinonasal masses treated at a rural tertiary care hospital in rural western Maharashtra from period of Jan 2016 to May 2018. History, clinical assessment and histopathological examination (HPE) was done in all cases as per hospital record supplemented by radiological investigation as per requirement. The patients were grouped as per their histopathological diagnosis as non-neoplastic/inflammatory and neoplastic.</p><p><strong>Results:</strong> A total of 70 patients were analysed age ranging (11-70 years). Majority of the patients were in the age groups 21-40 years (47%). There were 43 (61%) male and 27 (39%) female with M:F ratio 1.6:1. On HPE, 50 (71%) cases were non neoplastic/inflammatory and 20 (29%) cases were neoplastic lesions. HPE revealed that 50 (71%) cases were non neoplastic and 20 (29%) cases were neoplastic lesions.</p><p><strong>Conclusions:</strong> Sinonasal masses have various differential diagnoses. They are fairly common with male predominance. Benign conditions show a peak during 2<sup>nd</sup> to 4<sup>th</sup> decade of life while malignancy increasing with the age after 4th decade. In non-neoplastic lesion, Allergic nasal polyp is the commonest histological pattern seen while in malignant lesions squamous cell carcinoma is noted with 100% male predominance.</p><p> </p>

scholarly journals Clinical aspects of palmoplantar dermatoses in patients attending tertiary health care centre

2020 ◽  
Vol 6 (3) ◽  
pp. 383
Author(s):  
Yashodha Hassan Vasanthkumar ◽  
Mangala Hedne Chandrasekhar ◽  
Shamnur Basavrajappa Murugesh
Keyword(s):  
Clinical Symptoms ◽  
Early Recognition ◽  
Tertiary Care ◽  
Clinical Aspects ◽  
Age Group ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Health Care Centre ◽  
Cross Sectional ◽  
Male Predominance

<p class="abstract"><strong>Background:</strong> Dermatoses affecting palms and soles are among the most difficult of all dermatological therapeutic problems. Apart from diagnostic difficulties, few palmoplantar dermatoses cause great discomfort and disability and may also affect a person's livelihood. To evaluate demographic aspects like age and gender wise distribution and clinical profile of patients suffering from palmoplantar dermatoses.</p><p class="abstract"><strong>Methods:</strong> This cross-sectional study was conducted between August 2018 to July 2019 in the Department of Dermatology, venereology and leprosy in tertiary care centre. Total 200 cases attending the department of dermatology primarily with complaints pertaining to palms and soles with or without body part involvement in patients of age group between 5-70 yrs. and both sexes were enrolled in the study. Investigations such as direct microscopic examination of scrapings, wet mount with potassium hydroxide, Wood’s lamp examination, patch testing and sample for biopsy was taken. After taking consent a detailed history and clinical examination pertaining to the aim of the study was recorded and analysed.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 200 patients were enrolled, among which 63% were males and 37% were females showing male predominance. The most common age group affected was 21-40 years. The most common chief complaint was itching (41.5%). Palmoplantar psoriasis was the most common dermatosis with 23.5% cases.</p><p class="abstract"><strong>Conclusions:</strong> Palmoplantar dermatoses are frequently encountered in the dermatologic field. Early recognition of clinical symptoms and signs aids in diagnostic investigations and helps in appropriate and effective management of illness to improve the quality of life.</p>

scholarly journals Histomorphological analysis and clinical correlation of neoplastic and non neoplastic skin lesions: a study in a tertiary care centre of Western Uttar Pradesh, India

2020 ◽  
Vol 8 (8) ◽  
pp. 2820
Author(s):  
Mithila Bisht ◽  
Anjana Arya ◽  
B. C. Choudhry
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Uttar Pradesh ◽  
Skin Lesions ◽  
Punch Biopsy ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Tertiary Care Centre ◽  
Male Predominance ◽  
Dermatological Disorders

Background: Clinical examination may suffice in making diagnosis of most dermatologic disorders but histopathological examination is often required to confirm the diagnosis and further categorize the lesions. Authors carried out this study to analyse the demographic and histomorphological characteristics of skin lesions, to determine the frequency of various dermatological disorders in the region and to evaluate the agreement between clinical and histopathological diagnosis.Methods: Punch biopsies of skin lesions received in histopathology section, were included in the study. Cases over a period of six months were analysed. Clinical details were recorded and histopathological analysis done. Special stains were applied wherever required.Results: Of the 120 cases studied, maximum cases fell in the category of 31-40 years, with male predominance.  Authors observed wide variety of non-neoplastic and neoplastic lesions. Infectious diseases were the most common of all pathologies. Leprosy was the most common histopathological diagnosis. Complete clinicopathologic correlation was seen in 51.67% of cases while partial correlation was noted in 23.33% making a total of 75%. 25% histopathological diagnosis were inconsistent with the clinical diagnosis.Conclusions: Histopathology is a gold standard investigation and plays a very important role in confirmation of clinical diagnosis of various skin lesions. Punch biopsy is a relatively easy outpatient procedure to perform.

scholarly journals A retrospective study of brochoscopic profile of patients in a tertiary care centre

2018 ◽  
Vol 6 (3) ◽  
pp. 808
Author(s):  
Amit Kumar ◽  
Prashant Choudhary ◽  
Javed Khan ◽  
Rishi Saini
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Common Finding ◽  
Histopathological Diagnosis ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Demographic Profiles ◽  
Mucosal Growth ◽  
Endobronchial Growth ◽  
Nonspecific Inflammation

Background: The purpose of this study was to find out the demographic profiles, indications, bronchoscopic findings and diagnosis of the patients who underwent bronchoscopic examination.Methods: A retrospective analysis of 200 consecutive fiber-optic bronchoscopies was performed at RMCH from June 2015 to June 2017 to find out the demographic and clinical profile of the patients who underwent this procedure. The instrument Olympus video bronchoscope was used for the procedure.Results: Among total of 200 patients, 131 (65.5%) were males and 69 (34.5%) patients were females. 150 (75%) patients were smokers and 50 (25%) patients were non- smokers. Cough was the most common presenting symptom in 180 (90%) of the patients followed by breathlessness 138 (69%), chest pain 114 (57%), hemoptysis 80 (40%), fever 66 (33%). The most common finding is endobronchial growth in 119 (59.5%) followed by nonspecific inflammation 40 (20%), inconclusive 21 (10.5%), normal 12 (6%), suspected growth 8 (4%).Out of 200 patient biopsy was done in 65 patients (32.5%) and most common histopathological diagnosis was malignancy 42 (64.61%), pulmonary tuberculosis 10 (15.38%), Infective pathology 9 (13.8%), inconclusive 4 (6.1%).Conclusions:Bronchoscopy is a safe and useful tool for making the diagnosis of a variety of pulmonary diseases. Endobronchial growth and malignancy were the commonest findings on bronchoscopy and histopathological examination respectively. Moreover, we would like to emphasize the importance of attempting biopsy from the abnormal segment of the lung even when bronchoscopy does not show frank mucosal growth. 

Sign in / Sign up

Export Citation Format

Share Document