scholarly journals Peran Ginkgo biloba terhadap pencegahan gangguan dengar sensorineural pada terapi sisplatin penderita tumor ganas

2015 ◽  
Vol 44 (2) ◽  
pp. 96 ◽  
Author(s):  
Raden Mohamad Krisna Barata ◽  
Muhammad Thaufiq Siddiq Boesoirie ◽  
Ratna Anggraeni Soepardi Poerwana
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Ginkgo Biloba ◽  
Malignant Tumors ◽  
Otoacoustic Emission ◽  
Ginkgo Biloba Extract ◽  
Sensorineural Hearing ◽  
Egb 761 ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

Latar belakang: Kemoterapi sisplatin adalah terapi yang sering diberikan untuk penderita tumor ganas yang mempunyai efek samping ototoksik dengan terbentuknya radikal bebas yang enyebabkan kematian sel rambut luar koklea sehingga terjadi gangguan dengar. Ginkgo biloba adalah antioksidan yang terbukti memiliki efek otoprotektif terhadap ototoksisitas akibat sisplatin dengan menghambat pembentukan radikal bebas. Tujuan: Mengetahui peran Ginkgo biloba terhadap pencegahan gangguan dengar sensorineural pada penderita tumor ganas dengan sisplatin. Metode: Penelitian ini merupakan penelitian uji klinis acak dengan sampel adalah semua penderita tumor ganas yang mendapat kemoterapi sisplatin di Rumah Sakit Hasan Sadikin pada bulan Oktober 2013 sampai Januari 2014. Sampel dibagi dua, kelompok perlakuan menjalani pengobatan kemoterapi sisplatin dengan tambahan ekstrak Ginkgo biloba (Egb 761) peroral 80 mg perhari sejak 1 hari sebelum kemoterapi selama 30 hari. Kelompok kontrol menjalani pengobatan kemoterapi sisplatin saja. Pemeriksaan fungsi pendengaran dilakukan dengan timpanometri, audiometri, dan Distortion Product Otoacoustic Emission (DPOAE) sebelum dan setelah kemoterapi sisplatin siklus pertama dan kedua. Hasil: Didapatkan total 40 data dari 20 pasien yang dibagi dalam dua kelompok. Kejadian gangguan dengar sensorineural setelah siklus pertama dengan pemeriksaan DPOAE didapatkan perbedaan yang bermakna (p=0,027). Kesimpulan: Pemberian terapi ekstrak Ginkgo biloba 80 mg peroral dapat mencegah gangguan dengar sensorineural akibat kemoterapi sisplatin pada penderita tumor ganas. Kata kunci: Sisplatin, Ginkgo biloba, ototoksik, gangguan dengar sensorineural, tumor ganas.ABSTRACTBackground: Chemotherapy with cisplatin is a treatment which often given to patients with malignant tumors with side effects of ototoxicity due to the formation of free radicals that caused cochlea outer hair cells death, causing hearing impairment. Ginkgo biloba is an antioxidant with otoprotective effect to cisplatin induced ototoxicity by inhibiting the formation of free radicals. Purpose:To find out the role of Ginkgo biloba against sensorineural hearing loss in patients with malignant tumors treated with cisplatin. Methods: This is a quasiexperimental clinical trial. The subject were all patients with malignant tumors who received cisplatin chemotherapy in Hasan Sadikin Hospital from October 2013 until January 2014. Sample was divided into 2 groups, the first group (treatment) are those who undergoing cisplatin chemotherapy treatment with additional Ginkgo biloba extract (EGb 761) 80 mg per day orally, started from 1 day prior chemotherapy for 30 days. The second group (control) is those who underwnet only cisplatin chemotherapy. Auditory function were assesed by tympanometry, audiometry and Distortion Product Otoacoustic Emission (DPOAE) examination before and after the first and second cycles cisplatin chemotherapy. Result: The data from right and left ear were analyzed separately, giving total 40 data from 20 patients divided in 2 groups. The incidence of sensorineural hearing loss after first cycle of chemotherapy with the DPOAE results showed significant differencess (p=0,027). Conclusion: Ginkgo biloba extract 80 mg perday orally could prevent cisplatin-induced ototoxicity in patients with malignancy. Keywords: Cisplatin, Ginkgo biloba, ototoxic, sensorineural hearing loss, malignant tumors.

scholarly journals The most informative otoacoustic emission indicators for prognostication the course and solving expert issues in the participants of the joint forces operation with combat acutrauma

2021 ◽  
pp. 33-39
Author(s):  
Tetiana A. Shidlovskaya ◽  
Olexander Ye. Kononov ◽  
Lyubov G. Petruk
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Auditory System ◽  
Otoacoustic Emission ◽  
Sensorineural Hearing ◽  
Positive Test ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Group 2 ◽  
Group 1

Introduction: Registration of otoacoustic emission is the general objective method in diagnostics of receptor defeats of the auditory system, first of all the organ of Corti outer hair cells. At an acutrauma the receptive field of auditory system suffers. The purpose: to determine the possible prognostic criteria of progression of perceptual hearing disorders according to distortion-product otoacoustic emission (DPOAE) in servicemen who received acutrauma in real combat conditions. Material and methods: In the this work indicators for distortion-product otoacoustic emission (DPOAE) in servicemen who received acutrauma in the area of the joint forces operation have been investigated. We had examined 2 groups of people: 1st group – 30 persons who had shown improvement in auditory function and general condition after treatment, 2nd group – 30 persons in whom disease progression had observed, they had no positive dynamics after treatment. The investigation of otoacoustic emission (OAE) was conducted by analyzing system “Eclipse” of the “Interacoustics” Company (Denmark). Was used the generally accepted methodology. The recording has performed in the frequency band (1 - 6) kHz. Results. The complete adequate response of OAE across the entire frequency spectrum has been registered in only one patient with combat acutrauma from group 1. In most of the surveyed patients in whom the OAE was registered, a partially positive test was obtained as already mentioned. The response was considered as registered when the signal-to-noise ratio exceeded or was equal to 3 dB. The decision on a partially positive test was made when only one or more of the tested frequency bands had an adequate response. A positive response was registered in 42.6% of fighters of group 1 and 31.25% of group 2. According to our data, in patients of group 1 in 57.4% of cases the DPOAE was not registered at any of the frequencies, the same situation in patients of group 2 were in 68.75%. Thus in group 1 positive, including in part, the DPOAE was recorded at one frequency in 16.7% of cases, at twо frequencies - at 18.5%, at three frequencies - 7.4% and at four frequencies -1 . 8%. In group 2, a positive test was registered at one frequency in 16.7% of cases, at twо frequencies - 4.2% at three frequencies - 6.2%. At four frequencies, a positive test (complete response) was not registered in any patient of group 2. We analyzed at which frequencies the response was most often recorded with partially positive DPOAE results in surveyed patients. The corresponding percentages were calculated from the total number of received responses. At the same time, in patients of group 1 partial response of DPOAE have been registered more often than in group 2. In group 1, DPOAE was recorded at frequencies of 1 kHz in 52.2% of cases, 2 kHz - 34.8%, 4 kHz - 78.3%, 6 kHz - 21.7%. In persons from group 2, with a progressive course of sensorineural hearing loss, the DPOAE response was observed at frequencies of 1 kHz - 38.5%, 2 kHz - 46.1%, 4 kHz - 53.8%, 6 kHz - 23.1%. Thus, in both groups, the DPOAE response have been most often recorded at 4 kHz: (78.3%) and (53.8%), respectively. It is followed by the frequency of registration in 1 group with a frequency of 1 kHz (52.2%), and in group 2 with 2 kHz (46.1%). Thus, registration of the DPOAE will promote objectification of sensorineural hearing loss course at a combat acutrauma. Conclusions: The conducted researches have shown the importance of DPOAE definition at patients with a combat acutrauma that promotes timely and objective detection of receptor structures defeats of the auditory system at such patients. The results of DPOAE registration can be used to predict the course of sensorineural hearing loss and assess adverse factors in combat acutrauma. Complete absence of registration of DPOAE at servicemen with a combat acutrauma can serve as an objective sign of prognostically unfavorable course of sensorineural hearing loss at such patients.

Distortion Product Otoacoustic Emission Test of Sensorineural Hearing Loss in Humans: Comparison of Unequal- and Equal-Level Stimuli

1996 ◽  
Vol 105 (12) ◽  
pp. 982-990 ◽  
Author(s):  
Xiao-Ming Sun ◽  
Marjorie D. Jung ◽  
Duck O. Kim ◽  
Kenneth J. Randolph
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Correlation Coefficient ◽  
Roc Curve ◽  
Test Performance ◽  
Sensorineural Hearing ◽  
Wilcoxon Test ◽  
Impaired Hearing ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

Distortion product otoacoustic emissions (DPOEs) at the frequency of 2f1 — f2 (f1 < f2) were measured in 77 human adult ears with normal hearing or sensorineural hearing loss. The purpose of this study was to compare the performances of DPOE tests conducted with two sets of stimuli: 1) L1 = 65, L2 = 50 dB sound pressure level (SPL) re 20 μPa (“65/50”), and 2) L1 = L2 = 65 dB SPL (“65/65”). Half-octave DPOE root-mean-square levels at 1,000, 2,000,4,000, and 6,000 Hz were computed from the initial DPOEs measured at 0.25-octave intervals. Correlation coefficient and decision-theory analyses were applied to evaluate the DPOE test performance. For both stimuli, DPOE level exhibited significant correlation with pure tone hearing threshold. When the criterion DPOE level distinguishing normal from impaired hearing was adjusted, the curves of sensitivity and specificity crossed, and the values at the crossing were higher than 80% at frequencies of 2,000 to 6,000 Hz for both stimuli. The area under the receiver operating characteristic (ROC) curve, which provides an overall evaluation of the test performance independent of the criterion DPOE level, was .90 or higher at 2,000 to 6,000 Hz for both stimuli. At 2,000 and 4,000 Hz, all measures of test performance were higher for the 65/50 stimulus than the 65/65 stimulus: area under the ROC curve (.96 to .97 versus .90 to .91, statistically significant, p < .001, Wilcoxon test), sensitivity/specificity (90% to 93% versus 80% to 85%), and correlation coefficient (.78 to .87 versus .66 to .79). At 1,000 and 6,000 Hz, the performances of the DPOE tests were similar for the two stimuli. These results support the conclusion that a DPOE test with L1 = 65 and L2 = 50 dB SPL provides a better performance than that with L1 = L2 = 65 dB SPL and recommend the use of stimuli with L1 being higher than L2 by about 15 dB. These results also support a growing view that 2f1 — f2 DPOEs can be utilized clinically as a reliable method of testing human sensorineural hearing loss.

Effect of mastoid drilling on hearing of the contralateral ear

2013 ◽  
Vol 127 (10) ◽  
pp. 952-956 ◽  
Author(s):  
A Goyal ◽  
P P Singh ◽  
A Vashishth
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Prospective Clinical Study ◽  
Distortion Product Otoacoustic Emission ◽  
High Frequencies ◽  
Distortion Product ◽  
Contralateral Ear

AbstractObjectives:This study aimed to: understand the effect that high intensity noise associated with drilling (during otological surgery) has on hearing in the contralateral ear; determine the nature of hearing loss, if any, by establishing whether it is temporary or persistent; and examine the association between hearing loss and various drill parameters.Methods:A prospective clinical study was carried out at a tertiary centre. Thirty patients with unilateral cholesteatoma and normal contralateral hearing were included. Patients were evaluated pre-operatively and for five days following surgery using high frequency pure tone audiometry, and low and high frequency transient evoked and distortion product otoacoustic emission testing.Results:The findings revealed statistically significant changes in distortion product otoacoustic emissions at high frequencies (p = 0.016), and in transient evoked otoacoustic emissions at both low and high frequencies (p = 0.035 and 0.021, respectively). There was a higher statistical association between otoacoustic emission changes and cutting burrs compared with diamond burrs.Conclusion:Drilling during mastoid surgery poses a threat to hearing in the contralateral ear due to noise and vibration conducted transcranially.

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