Cryptomeria japonica (L. F.) D. Don as source of shikimic acid

Oseltamivir phosphate (OSP), marketed under the brand name of Tamiflu®, is a potent inhibitor of viral neuraminidase, a glycoside hydrolase enzyme essential for viral replication. OSP is also important to control influenza virus (H1N1) and is produced mainly from shikimic acid (SA) extracted from plants. The main source of SA is from seeds of I. verum. Alternatives to meet the worldwide demand are necessary. One of this is Cryptomeria japonica. In this study, we found a content of 56.36 mg.kg-1 of SA in dried biomass for C. japonica, while for I.verum, the traditional source, was 96.57 mg.kg-1. Due to the fact of C. japonica is a tree, exploited for commercial production, it can be a renewable and reliable source SA for OSP production.

Download Full-text

An equine herpesvirus 1 (EHV-1) vectored H1 vaccine protects against challenge with swine-origin influenza virus H1N1

Veterinary Microbiology ◽

10.1016/j.vetmic.2011.07.003 ◽

2011 ◽

Vol 154 (1-2) ◽

pp. 113-123 ◽

Cited By ~ 9

Author(s):

Abdelrahman Said ◽

Armando Damiani ◽

Guanggang Ma ◽

Donata Kalthoff ◽

Martin Beer ◽

...

Keyword(s):

Influenza Virus ◽

Equine Herpesvirus ◽

Virus H1n1 ◽

Equine Herpesvirus 1 ◽

Herpesvirus 1

Download Full-text

Antiviral Activity of Fritillaria thunbergii Extract against Human Influenza Virus H1N1 (PR8) In Vitro, In Ovo and In Vivo

Journal of Microbiology and Biotechnology ◽

10.4014/jmb.1908.08001 ◽

2020 ◽

Vol 30 (2) ◽

pp. 172-177 ◽

Cited By ~ 3

Author(s):

Minjee Kim ◽

Dinh-Van Nguyen ◽

Yoonki Heo ◽

Ki Hoon Park ◽

Hyun-Dong Paik ◽

...

Keyword(s):

Influenza Virus ◽

Antiviral Activity ◽

Virus H1n1 ◽

Human Influenza ◽

In Ovo ◽

Human Influenza Virus

Download Full-text

Phylogenetic Analysis of HA Proteins of Influenza Virus H1N1 Reveal New Insight on Virus Pandemic

Bio-Science and Bio-Technology - Communications in Computer and Information Science ◽

10.1007/978-3-642-10616-3_20 ◽

2009 ◽

pp. 146-150

Author(s):

Kuo-yuan Hwa

Keyword(s):

Phylogenetic Analysis ◽

Influenza Virus ◽

Virus H1n1

Download Full-text

Shikimic acid as intermediary model for the production of drugs effective against influenza virus

Phytochemicals as Lead Compounds for New Drug Discovery ◽

10.1016/b978-0-12-817890-4.00016-0 ◽

2020 ◽

pp. 245-256 ◽

Cited By ~ 1

Author(s):

Priyanka Singh ◽

Ena Gupta ◽

Neha Mishra ◽

Pragya Mishra

Keyword(s):

Influenza Virus ◽

Shikimic Acid

Download Full-text

#Nitrosocarbonyls 1: Antiviral Activity ofN-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1

The Scientific World JOURNAL ◽

10.1155/2014/472373 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Dalya Al-Saad ◽

Misal Giuseppe Memeo ◽

Paolo Quadrelli

Keyword(s):

Influenza Virus ◽

Antiviral Activity ◽

Small Molecules ◽

Influenza A ◽

Nucleoside Analogues ◽

Virus H1n1 ◽

Antiviral Activities ◽

Synthetic Approaches ◽

Carbocyclic Nucleoside

Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with thein vitroantiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1.

Download Full-text

Comparison of anti-influenza virus activity and pharmacokinetics of oseltamivir free base and oseltamivir phosphate

The Journal of Microbiology ◽

10.1007/s12275-017-7371-x ◽

2017 ◽

Vol 55 (12) ◽

pp. 979-983 ◽

Cited By ~ 5

Author(s):

Jin Soo Shin ◽

Keun Bon Ku ◽

Yejin Jang ◽

Yi-Seul Yoon ◽

Daeho Shin ◽

...

Keyword(s):

Influenza Virus ◽

Free Base ◽

Virus Activity ◽

Oseltamivir Phosphate

Download Full-text

Immunogenicity, Boostability, and Sustainability of the Immune Response after Vaccination against Influenza A Virus (H1N1) 2009 in a Healthy Population

Clinical and Vaccine Immunology ◽

10.1128/cvi.05046-11 ◽

2011 ◽

Vol 18 (9) ◽

pp. 1401-1405 ◽

Cited By ~ 36

Author(s):

Elisabeth Huijskens ◽

John Rossen ◽

Paul Mulder ◽

Ruud van Beek ◽

Hennie van Vugt ◽

...

Keyword(s):

Immune Response ◽

Influenza Virus ◽

Influenza A Virus ◽

Influenza A ◽

Seasonal Influenza ◽

Virus H1n1 ◽

Prospective Longitudinal Study ◽

Virus Vaccination ◽

Short Period ◽

Prospective Longitudinal

ABSTRACTThe emergence of a new influenza A virus (H1N1) variant in 2009 led to a worldwide vaccination program, which was prepared in a relatively short period of time. This study investigated the humoral immunity against this virus before and after vaccination with a 2009 influenza A virus (H1N1) monovalent MF59-adjuvanted vaccine, as well as the persistence of vaccine-induced antibodies. Our prospective longitudinal study included 498 health care workers (mean age, 43 years; median age, 44 years). Most (89%) had never or only occasionally received a seasonal influenza virus vaccine, and 11% were vaccinated annually (on average, for >10 years). Antibody titers were determined by a hemagglutination inhibition (HI) assay at baseline, 3 weeks after the first vaccination, and 5 weeks and 7 months after the second vaccination. Four hundred thirty-five persons received two doses of the 2009 vaccine. After the first dose, 79.5% developed a HI titer of ≥40. This percentage increased to 83.3% after the second dose. Persistent antibodies were found in 71.9% of the group that had not received annual vaccinations and in 43.8% of the group that had received annual vaccinations. The latter group tended to have lower HI titers (P=0.09). With increasing age, HI titers decreased significantly, by 2.4% per year. A single dose of the 2009 vaccine was immunogenic in almost 80% of the study population, whereas an additional dose resulted in significantly increased titers only in persons over 50. Finally, a reduced HI antibody response against the 2009 vaccine was found in adults who had previously received seasonal influenza virus vaccination. More studies on the effect of yearly seasonal influenza virus vaccination on the immune response are warranted.

Download Full-text