Increased level of malondialdehyde in preterm labor

Background: The pathophysiological mechanism associated with spontaneous preterm delivery is oxidative stress through the increased formation of reactive oxygen species (ROS) due to lipid peroxidation. Malondialdehyde (MDA) is one of the biomarkers of oxidative stress produced through the lipid peroxidation process. Objective: The aim of this study is to observe the difference in MDA levels among preterm labor compared to full-term labor. Methods: Observational research was conducted with a comparative cross-sectional design. Maternal venous blood samples were taken from private hospitals and midwives in Padang city and Aro Suka Hospital Solok Regency. Samples were selected by consecutive sampling and divided into two groups with a total of 40 samples. MDA level was measured using the spectrophotometry method. Results: MDA levels in preterm delivery were 3,6±0.42 nmol/mL and in full-term delivery were 2.9±0.33 nmol/mL. Conclusion: There was a significant difference in MDA levels between preterm labor and full-term delivery. MDA levels in preterm childbirth were higher than MDA levels in full-term delivery.

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The Rate of Asymptomatic Bacteriuria is Similar in Term and Preterm Delivery

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v37i1.329 ◽

2016 ◽

Author(s):

Riska Amelia

Keyword(s):

Pregnant Women ◽

Preterm Delivery ◽

Preterm Labor ◽

Obstet Gynecol ◽

Urine Analysis ◽

Urine Culture ◽

Asymptomatic Bacteriuria ◽

Significant Difference ◽

Term Delivery ◽

The Subject

Objectives: To show the prevalence of asymptomatic bacteriuria in pregnant women and to find its correlation with preterm labor. Methods: This research was performed in Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. A total of 78 subjects joined this research. The first group consisted of 39 subjects that were having preterm delivery and the second group consisted of 39 subjects that were having term delivery. Urine analysis and culture were done in both groups. The subject was being considered to have asymptomatic bacteriuria if the urine culture showed a minimum of 100,000 bacteria/ml without any symptoms or signs of urinary tract infection. The number was then analyzed to reveal the correlation of asymptomatic bacteriuria with preterm delivery. Results: There were a significantly higher number of preterm deliveries in subjects whose age ranged between 15-19 year-old (28.20% vs 12.8%; p=0.033). While on the contrary, there was a significantly lower number of preterm delivery in subjects whose age ranged between 30-34 year-old (25.6% vs 5.12%; p=0.020).The incidence number of asymptomatic bacteriuria among all subjects is 21.79%. There was no significant difference of asymptomatic bacteriuria between preterm and a term delivery (23.07% vs 20.51%; p=0.784). Conclusions: There was no significant difference of asymptomatic bacteriuria between the subject with preterm delivery and term delivery, but the incidence of asymptomatic bacteriuria in pregnant women in this study was quite high, reaching eight times higher than those stated in other study. Thus, routine urine culture screening policy in early pregnancy still cannot be omitted, considering that asymptomatic bacteriuria can lead to pyelonephritis which can cause maternal and fetal morbidity. [Indones J Obstet Gynecol; 37-1: 8-11] Keywords: asymptomatic bacteriuria, urine analysis, urine culture, preterm delivery

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STUDY OF HAEMOGLOBIN, IRON AND FERRITIN LEVELS IN PRETERM DELIVERY

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i2.990 ◽

2020 ◽

Vol 4 (2) ◽

Author(s):

Ankita Kondhalkar ◽

Rakesh Kumar Jha

Keyword(s):

Preterm Delivery ◽

Serum Ferritin ◽

Serum Iron ◽

Predictive Biomarker ◽

Serum Levels ◽

Acute Phase Reactant ◽

Full Term ◽

Mortality And Morbidity ◽

Term Delivery ◽

Full Term Delivery

Introduction: Preterm birth (PTB) is a major determinant of neonatal mortality and morbidity. Preterm babies are prone to serious illness or death during the neonatal period. PTB is one of the unresolved problems in clinical obstetrics and one of the greatest threats to the developing fetus, there is need to determine predictive biomarker for preterm delivery. Therefore present study aimed to assess serum levels of haemoglobin, iron and Ferittin in preterm and full-term delivery Materials & Methods: The present study includes total 80 subjects that comprise forty women presenting with preterm onset of labor followed by delivery and forty women who delivered at term served as controls. Blood Samples from the patients were obtained for haemoglobin, iron and ferritin estimation, when patient was in labor. Serum Iron was estimated by coral clinical kit method. Serum ferritin was performed by Electrochemiluminescence method. Haemoglobin levels were measured by automated haematology analyser. Results: Serum ferritin levels were significantly increased (P<0.001) in preterm delivery as compared to full term delivery. Haemoglobin levels are significantly decreased in preterm delivery (p<0.001) as compared to full term delivery. Serum iron levels were non significantly increased in preterm delivery as compare to the full-term delivery. (P ≤0.05). Conclusion: Our study showed that low levels of Haemoglobin and elevated ferritin levels may be associated with preterm delivery in asymptomatic pregnant women. Though ferritin is an acute phase reactant is elevated in women predisposed to preterm delivery. Keywords: HAEMOGLOBIN, IRON, FERRITIN, PTB, CVF, BMI

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Ceruloplasmin and Alkaline Phosphatase Levels in Preterm Delivery

International Journal of Biochemistry Research & Review ◽

10.9734/ijbcrr/2019/v28i230140 ◽

2019 ◽

pp. 1-6

Author(s):

A. Kondhalkar ◽

K. More ◽

S. Kumar

Keyword(s):

Alkaline Phosphatase ◽

Preterm Delivery ◽

Serum Alkaline Phosphatase ◽

Predictive Biomarker ◽

Acute Phase Reactant ◽

Full Term ◽

Mortality And Morbidity ◽

Serum Ceruloplasmin ◽

Term Delivery ◽

Full Term Delivery

Introduction: Preterm birth (PTB) is a major determinant of neonatal mortality and morbidity. Preterm babies are prone to serious illness or death during the neonatal period. PTB is one of the unresolved problems in clinical obstetrics and one of the greatest threats to the developing fetus, there is need to determine predictive biomarker for preterm delivery. Therefore present study aimed to assess serum levels of ceruloplasmin and Alkaline phosphatase in preterm and full-term delivery. Materials and Methods: The present study includes total 80 subjects that comprise forty women presenting with preterm onset of labor followed by delivery and forty women who delivered at term served as controls. Blood Samples from the subjects were obtained for ceruloplasmin and Alkaline phosphatase estimation, when patient was in labor. Serum ceruloplasmin and alkaline phosphatase measured spectrophotometrically. Serum ceruloplasmin was estimated by Herbert A Ravin and Henry et al. method. Serum alkaline phosphatase was estimated by Kinetic p-NPP method. Results: Serum ceruloplasmin levels were significantly increased (P<0.001) in preterm delivery as compared to full term delivery. Alkaline phosphatase levels are significantly increased in preterm delivery (p<0.001) as compared to full term delivery. Conclusion: Our study showed that elevated levels of ceruloplasmin and alkaline phosphatase may be associated with preterm delivery in asymptomatic pregnant women. The elevated ALP may be due to mild chronic subclinical infection which may be responsible for preterm delivery. Ceruloplasmin is acute phase reactant, increased due to an antioxidant defence mechanism against oxidative stress.

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