scholarly journals Ultrasound-Microbubble Combined Treatment with Vinca Alkaloids in Prostate Cancer Cells

2021 ◽  
Author(s):  
Aren Gharabeiki
Keyword(s):  
Prostate Cancer ◽  
Combined Treatment ◽  
Vinca Alkaloid ◽  
Chemotherapeutic Agents ◽  
Vinca Alkaloids ◽  
Prostate Cancer Cells ◽  
Viability Analysis ◽  
Drug Molecules ◽  
Peak Negative Pressure ◽  
Vinblastine Sulfate

Therapeutic efficacy of chemotherapy is highly dependent on the ability to deliver drug molecules across tissue and cellular barriers. Ultrasound stimulated microbubbles (USMB) have been shown to enhance the delivery and cytotoxicity of various classes of chemotherapeutic agents. Here, the application of USMB in combination with the chemotherapeutic class vinca alkaloids is investigated. Specifically, vinorelbine tartrate (VRL) and vinblastine sulfate (VBL) of the vinca alkaloid class, which to the best of our knowledge have not been reported in combination with USMB, were used in this study. Cell viability analysis demonstrated that USMB does not enhance the cytotoxicity of either drug. VRL+USMB showed to have an additive response in cell death, whereas VBL+USMB resulted in an additive effect at a low peak negative pressure, and antagonistic at higher pressures. This work suggests that the mechanism of uptake is an important factor in determining the effectiveness of a chemotherapy drug with USMB treatment.

scholarly journals Ultrasound-Microbubble Combined Treatment with Vinca Alkaloids in Prostate Cancer Cells

2021 ◽  
Author(s):  
Aren Gharabeiki
Keyword(s):  
Prostate Cancer ◽  
Combined Treatment ◽  
Vinca Alkaloid ◽  
Chemotherapeutic Agents ◽  
Vinca Alkaloids ◽  
Prostate Cancer Cells ◽  
Viability Analysis ◽  
Drug Molecules ◽  
Peak Negative Pressure ◽  
Vinblastine Sulfate

Therapeutic efficacy of chemotherapy is highly dependent on the ability to deliver drug molecules across tissue and cellular barriers. Ultrasound stimulated microbubbles (USMB) have been shown to enhance the delivery and cytotoxicity of various classes of chemotherapeutic agents. Here, the application of USMB in combination with the chemotherapeutic class vinca alkaloids is investigated. Specifically, vinorelbine tartrate (VRL) and vinblastine sulfate (VBL) of the vinca alkaloid class, which to the best of our knowledge have not been reported in combination with USMB, were used in this study. Cell viability analysis demonstrated that USMB does not enhance the cytotoxicity of either drug. VRL+USMB showed to have an additive response in cell death, whereas VBL+USMB resulted in an additive effect at a low peak negative pressure, and antagonistic at higher pressures. This work suggests that the mechanism of uptake is an important factor in determining the effectiveness of a chemotherapy drug with USMB treatment.

scholarly journals A Review of the Potential of Phytochemicals from Prunus africana (Hook f.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Richard Komakech ◽  
Youngmin Kang ◽  
Jun-Hwan Lee ◽  
Francis Omujal
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Treatment Options ◽  
Chemotherapeutic Agents ◽  
Sub Saharan Africa ◽  
In Vivo Studies ◽  
Prostate Cancer Cells ◽  
Prunus Africana

Prostate cancer remains one of the major causes of death worldwide. In view of the limited treatment options for patients with prostate cancer, preventive and treatment approaches based on natural compounds can play an integral role in tackling this disease. Recent evidence supports the beneficial effects of plant-derived phytochemicals as chemopreventive and chemotherapeutic agents for various cancers, including prostate cancer. Prunus africana has been used for generations in African traditional medicine to treat prostate cancer. This review examined the potential roles of the phytochemicals from P. africana, an endangered, sub-Saharan Africa plant in the chemoprevention and chemotherapy of prostate cancer. In vitro and in vivo studies have provided strong pharmacological evidence for antiprostate cancer activities of P. africana-derived phytochemicals. Through synergistic interactions between different effective phytochemicals, P. africana extracts have been shown to exhibit very strong antiandrogenic and antiangiogenic activities and have the ability to kill tumor cells via apoptotic pathways, prevent the proliferation of prostate cancer cells, and alter the signaling pathways required for the maintenance of prostate cancer cells. However, further preclinical and clinical studies ought to be done to advance and eventually use these promising phytochemicals for the prevention and chemotherapy of human prostate cancer.

scholarly journals Combined Effects of Fe3O4 Nanoparticles and Chemotherapeutic Agents on Prostate Cancer Cells In Vitro

2018 ◽  
Vol 8 (1) ◽  
pp. 134 ◽  
Author(s):  
Kanako Kojima ◽  
Sanai Takahashi ◽  
Shungo Saito ◽  
Yoshihiro Endo ◽  
Tadashi Nittami ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Fe3o4 Nanoparticles ◽  
Chemotherapeutic Agents ◽  
Combined Effects ◽  
Prostate Cancer Cells

KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone

2010 ◽  
Vol 391 (4) ◽  
Author(s):  
Konstantinos Mavridis ◽  
Maroulio Talieri ◽  
Andreas Scorilas
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Chemotherapeutic Agents ◽  
Chemotherapeutic Drugs ◽  
Quantitative Real Time Pcr ◽  
Prostate Cancer Cells ◽  
Diagnosis And Prognosis ◽  
Mtt Method ◽  
Du145 Cells ◽  
Hormone Refractory

AbstractKallikrein-related peptidases (KLKs), includingKLK5, have been proposed as promising biomarkers for prostate cancer diagnosis and prognosis. In the present study, we report that distinct augmentations (up to 6.4-fold) ofKLK5mRNA expressional levels, calculated via quantitative real-time PCR, occur after treatment of DU145 cells with appropriate concentrations, determined by the MTT method, of docetaxel and mitoxantrone. Our data reveal the endogenous need of prostate cancer cells for modifiedKLK5expression to cope with the administration of chemotherapeutic drugs. Furthermore, it is proposed that the expression profile ofKLK5could serve as a putative biomarker for monitoring the treatment response in hormone refractory prostate cancer patients.

Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21WAF1/CIP1 and C/EBP? expressions and suppressing NF-?B activation

The Prostate ◽  
2002 ◽  
Vol 51 (3) ◽  
pp. 211-218 ◽  
Author(s):  
Tzyh-Chyuan Hour ◽  
Jun Chen ◽  
Chao-Yuan Huang ◽  
Jing-Yi Guan ◽  
Shiu-Hui Lu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Chemotherapeutic Agents ◽  
Prostate Cancer Cells
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