scholarly journals Dampak Coronavirus Disease 2019 (Covid-19) Pada Kehamilan Sejak Desember 2019 Hingga Agustus 2020 Melalui Tinjauan Literatur

2020 ◽  
Vol 1 (2) ◽  
pp. 14-22
Author(s):  
Sharon Silvia Rumfabe ◽  
Herlina Y ◽  
Pande M.D.A

Latar Belakang. Kehamilan merupakan periode perkembangan janin dalam rahim yang berlangsung sekitar 37-40 minggu. Perubahan fisiologis yang terjadi pada kehamilan dapat meningkatkan risiko kerentan terhadap penyakit infeksi, salah satunya infeksi COVID-19. Coronavirus Disesase (2019) merupakan penyakit yang disebabkan oleh varian baru coronavirus yang disebut Acute Severe Respiratory Syndrome 2 (SARS- CoV-2). COVID-19 pertama kali di laporkan pada tanggal 31 Desember 2019 oleh WHO China Country Office di Kota Wuhan, Provinsi Hubei, Cina. COVID -19 dapat berdampak pada wanita hamil maupun janinnya. Tujuan penelitian ini adalah untuk mengetahui dampak COVID-19 pada kehamilan melalui sebuah tinjauan literatur. Metode. Penelitian ini menggunakan metode tinjauan literatur dengan jenis systematic review. Pengumpulan data dilakukan dengan menggunakan artikel dari database PubMed, BMJ, NIH, dan Science Direct dengan kata kunci “Impact or consequence” and “COVID-19 or SARS-Cov-2” and “Pathophysiology” and “pregnancy” dan impact COVID-19 in pregnancy yang sesuai kriteria inklusi dan eksklusi penelitian ini. Diperoleh 17 artikel dan akan dilakukan tinjauan literatur. Hasil. Berdasarkan hasil tinjauan literatur dari 17 artikel, diperoleh hasil adanya dampak COVID-19 pada kehamilan. Dampak (COVID-19) pada kehamilan dapat dialami oleh janin, neonatus, bayi dan ibu. Hasil presentasi dampak COVID-19 pada kehamilan dari 17 artikel secara keseluruhan adalah demam (47%), batuk (47%), persalinan dengan operasi sesar (59%), dan persalinan prematur (41%), perawatan wanita hamil secara intensif (29%), kematian ibu (29%), kematian neonatus (23%), neonatus positif COVID-19 (23%), aborsi spontan (17%), lahir mati (17%), kematian intrauterin (17%), BBLR (17%), gawat janin (12%), dan asfiksia neonatal (17%), angka ini hanya membandingkan hasil antar artikel. Kesimpulan. Terdapat laporan mengenai adanya dampak COVID-19 pada kehamilan.

2019 ◽  
Author(s):  
Sangshin Park ◽  
Christina E. Nixon ◽  
Olivia Miller ◽  
Nam-Kyong Choi ◽  
Jonathan D. Kurtis ◽  
...  

2021 ◽  
Vol 11 (2) ◽  
pp. 283-294
Author(s):  
Gloria Ejehiohen Iyawa ◽  
Aliyu Rabiu Dansharif ◽  
Asiya Khan

Author(s):  
Ashley D. Davidson ◽  
Amritha Bhat ◽  
Frances Chu ◽  
Jessie N. Rice ◽  
N. Aba Nduom ◽  
...  

Author(s):  
O E Okosieme ◽  
Medha Agrawal ◽  
Danyal Usman ◽  
Carol Evans

Background: Gestational TSH and FT4 reference intervals may differ according to assay method but the extent of variation is unclear and has not been systematically evaluated. We conducted a systematic review of published studies on TSH and FT4 reference intervals in pregnancy. Our aim was to quantify method-related differences in gestation reference intervals, across four commonly used assay methods, Abbott, Beckman, Roche, and Siemens. Methods: We searched the literature for relevant studies, published between January 2000 and December 2020, in healthy pregnant women without thyroid antibodies or disease. For each study, we extracted trimester-specific reference intervals (2.5–97.5 percentiles) for TSH and FT4 as well as the manufacturer provided reference interval for the corresponding non-pregnant population. Results: TSH reference intervals showed a wide range of study-to-study differences with upper limits ranging from 2.33 to 8.30 mU/L. FT4 lower limits ranged from 4.40–13.93 pmol/L, with consistently lower reference intervals observed with the Beckman method. Differences between non-pregnant and first trimester reference intervals were highly variable, and for most studies the TSH upper limit in the first trimester could not be predicted or extrapolated from non-pregnant values. Conclusions: Our study confirms significant intra and inter-method disparities in gestational thyroid hormone reference intervals. The relationship between pregnant and non-pregnant values is inconsistent and does not support the existing practice in some laboratories of extrapolating gestation references from non-pregnant values. Laboratories should invest in deriving method-specific gestation reference intervals for their population.


Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2221
Author(s):  
Hugo G. Quezada-Pinedo ◽  
Florian Cassel ◽  
Liesbeth Duijts ◽  
Martina U. Muckenthaler ◽  
Max Gassmann ◽  
...  

In pregnancy, iron deficiency and iron overload increase the risk for adverse pregnancy outcomes, but the effects of maternal iron status on long-term child health are poorly understood. The aim of the study was to systematically review and analyze the literature on maternal iron status in pregnancy and long-term outcomes in the offspring after birth. We report a systematic review on maternal iron status during pregnancy in relation to child health outcomes after birth, from database inception until 21 January 2021, with methodological quality rating (Newcastle-Ottawa tool) and random-effect meta-analysis. (PROSPERO, CRD42020162202). The search identified 8139 studies, of which 44 were included, describing 12,7849 mother–child pairs. Heterogeneity amongst the studies was strong. Methodological quality was predominantly moderate to high. Iron status was measured usually late in pregnancy. The majority of studies compared categories based on maternal ferritin, however, definitions of iron deficiency differed across studies. The follow-up period was predominantly limited to infancy. Fifteen studies reported outcomes on child iron status or hemoglobin, 20 on neurodevelopmental outcomes, and the remainder on a variety of other outcomes. In half of the studies, low maternal iron status or iron deficiency was associated with adverse outcomes in children. Meta-analyses showed an association of maternal ferritin with child soluble transferrin receptor concentrations, though child ferritin, transferrin saturation, or hemoglobin values showed no consistent association. Studies on maternal iron status above normal, or iron excess, suggest deleterious effects on infant growth, cognition, and childhood Type 1 diabetes. Maternal iron status in pregnancy was not consistently associated with child iron status after birth. The very heterogeneous set of studies suggests detrimental effects of iron deficiency, and possibly also of overload, on other outcomes including child neurodevelopment. Studies are needed to determine clinically meaningful definitions of iron deficiency and overload in pregnancy.


Author(s):  
Maria Gaia Dodaro ◽  
Anna Seidenari ◽  
Ignazio R. Marino ◽  
Vincenzo Berghella ◽  
Federica Bellussi

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