Cavernous Sinus Thrombosis After Coronavirus Infection in A Patient with Type 2 Diabetes Mellitus- Case report

Background. Thrombotic complications after COVID-19 are described in literature in early period after acute phase of infection. Case presentation. This article presents a clinical case of a patient with type 2 diabetes mellitus with cavernous sinus thrombosis and maxillary osteomyelitis 4 months after COVID-19 infection. Conclusion. Prevention of thrombosis after COVID-19 is the cornerstone, the prevention period may need to be extended.

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Condition after Thrombosis of the Cavernous Sinus, Complicated by Osteomyelitis of the Upper Jaw after a Coronavirus Infection in a Patient With Type 2 Diabetes Mellitus

Juvenis scientia ◽

10.32415/jscientia_2021_7_3_28-35 ◽

2021 ◽

Vol 7 (3) ◽

pp. 28-35

Author(s):

F. A. Khaydarova ◽

A. V. Alieva ◽

T. T. Kamalov ◽

V. A. Talenova

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cavernous Sinus ◽

Clinical Manifestations ◽

The Body ◽

Increased Risk ◽

Coronavirus Infection ◽

Upper Jaw

One of the most global health problems today is the SARS-CoV-2 coronavirus pandemic and its numerous complications. COVID-19 was first reported in China in the city of Wuhan in December 2019. It was found that coronavirus infection leads to microvascular and macrovascular complications throughout the body. Recent data indicate a strong link between severe clinical manifestations of COVID-19 and an increased risk of thromboembolism. It is associated with several risk factors such as systemic hyperinflammation caused by coronavirus infection, hypoxia, and comorbidities. The pathophysiological mechanisms underlying coagulopathy associated with COVID-19 include diffuse damage to endothelial cells, abnormal blood flow dynamics, and uncontrolled platelet activation. Studying the situation during the COVID-19 pandemic, we can notice that patients develop various complications during or after COVID-19. This article describes a clinical case of a patient with type 2 diabetes mellitus who has developed cavernous sinus thrombosis complicated by osteomyelitis of the upper jaw after COVID-19 infection.

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Metabolic and hemostatic characteristics of patients with type 2 diabetes mellitus differing in the severity of angiopathy

Problems of Endocrinology ◽

10.14341/probl201056215-19 ◽

2010 ◽

Vol 56 (2) ◽

pp. 15-19 ◽

Cited By ~ 1

Author(s):

G G Petrik ◽

S A Pavlishchuk

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Early Period ◽

Vascular Pathology ◽

Diabetic Patients ◽

Platelet Disaggregation ◽

Aggregation Activity

The objective of the present study was to identify risk factors of developing vascular disorders in patients at different stages of type 2 diabetes mellitus (DM2) by comprehensive analysis of metabolic parameters, hemograms, thrombocytic and plasma hemostasis. The study involved 75 patients (22 men and 53 women of mean age 57,3±9,7 years) having angiopathies of different severity. The data obtained confirmed the presence of risk factors of vascular pathology in different phases of DM2. All the examined patients including those without angiopathies in the early period of diabetes showed triglyceridemia, cholesterolemia, enhanced platelet aggregation activity, and shortened activated partial thromboplastin time. Patients with diabetic nephropathy at the stage of microalbuminuria and with non-proliferative retinopathy were distinct from the remaining ones in that they had significantly higher blood alpha-2 globulin and fibrinogen levels. Diabetic patients with micro- and macrovascular problems were characterized by marked dysproteinemia and abnormal platelet disaggregation.

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