Aetiology of Neuropathic Pain (NP) Along with Role of Gabapentinoids Like Pregabalin and Gabapentin in Treating the Excruciating Pain Besides Other Newer Alternatives-a Systematic Review

Neuropathic pain (NP) by definition is a problem that involves the somatosensory system either as a manifestation as disease or as a lesion. Lot of differing causes either of central/peripheral origin can stimulate NP and that might affect life’s quality badly. Worldwide prevalence of NP varies from 6.9-10% with spinal cord injury (SCI) explaining 40% of them. The 2nd commonest cause is diabetic peripheral neuropathy (DPN) that accounts for 22-28% of type 2 diabetes mellitus (T2DM). After having reviewed thoroughly how to manage diabetic neuropathic pain here we decided to conduct a systematic review on varying causes of NP and the role of gabapentenoids in managing the excruciating pain. Besides newer opioid analogues not having addictive potential like fentanyl matrix with its availability in intradermal formulations, delta opioid receptor agonist BBI-11008, an innovative analog N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide (LMH2), that is like haloperidol, along with advantages of Gabapentin-ER as well as therapy of trigeminal neuralgia with anticonvulsants like carbamazepine and use in Immunotherapy utilizing 14,18 anti GD2 antibody (ch14.18) associated excruciating pain and in Meralgia paraesthetica (MP) is discussed besides alternative therapies when gabapentenoids fail.