Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) in patient with tongue cancer

doi:10.33140/jcrc.06.11.02

Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) in patient with tongue cancer

Journal of Clinical Review & Case Reports ◽

10.33140/jcrc.06.11.02 ◽

2021 ◽

Vol 6 (11) ◽

Keyword(s):

Rare Disease ◽

Cancer Patients ◽

Tongue Cancer ◽

Disease Entity ◽

Tonsil Cancer ◽

Topical Corticosteroids

Eosinophilic polymorphic and pruritic eruption associated with radiotherapy (EPPER) is a rare disease entity that appears in cancer patients after radiotherapy. We describe patient with tonsil cancer who presented with EPPER in an area that had been irradiated. The patient responded to the application of topical corticosteroids and systemic antihistamines.

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Sinonasal mucosal melanoma: treatment strategies and survival rates for a rare disease entity

Wiener klinische Wochenschrift ◽

10.1007/s00508-021-01847-6 ◽

2021 ◽

Author(s):

Alexandros Andrianakis ◽

Peter Kiss ◽

Markus Pomberger ◽

Axel Wolf ◽

Dietmar Thurnher ◽

...

Keyword(s):

Rare Disease ◽

Survival Data ◽

Survival Rates ◽

Delayed Diagnosis ◽

Distant Metastases ◽

Primary Treatment ◽

Mucosal Melanoma ◽

Disease Entity ◽

Improve Outcome ◽

Initial Symptoms

Summary Background Sinonasal mucosal melanoma (SNMM) is a rare disease entity comprising 0.4–1.3% of all melanomas. Surgery with free margins has been the primary treatment over decades. Neither the addition of radiotherapy nor chemotherapy could significantly improve outcome rates of this devastating malignancy. This study presents our clinical experience with SNMM over a 19-year period and summarizes the current body of literature on SNMM. Methods This retrospective analysis included 12 patients with SNMM treated from 2001 to 2019 at an academic center. Additionally, a literature review of the last 29 years on treatment and survival data of SNMM was conducted. Results Main initial symptoms were epistaxis and nasal obstruction. Of the patients 9 underwent endoscopic surgery, 6 received adjuvant therapy. 3 patients who did not undergo surgery, received chemoradiotherapy, radiotherapy alone, and chemotherapy alone, respectively. At the time of diagnosis 2 patients had distant metastases and 4 patients developed distant metastases during the course of the disease. Mean overall survival (OS) was 30.6 months, 3‑year and 5‑year OS were 25%, and 18.2%, respectively. Conclusion Unspecific symptoms and hidden anatomic locations lead to delayed diagnosis and increased rates of metastatic dissemination. Distant metastasis is the main treatment failure in SNMM. Surgery with free margins remains the primary treatment for SNMM. Adjuvant radiotherapy might improve local control in individual cases but efficient systemic therapy is needed to improve outcome rates. To evaluate and define more effective targeted treatment options and improve outcome rates, homogeneous data and prospective multicentric analysis are needed.

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Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients

International Journal of Cancer ◽

10.1002/ijc.20490 ◽

2004 ◽

Vol 112 (6) ◽

pp. 1015-1019 ◽

Cited By ~ 120

Author(s):

Liselotte Dahlgren ◽

Hanna (Mellin) Dahlstrand ◽

David Lindquist ◽

Anders Högmo ◽

Linda Björnestål ◽

...

Keyword(s):

Human Papillomavirus ◽

Prognostic Factor ◽

Cancer Patients ◽

Tongue Cancer ◽

Base Of Tongue ◽

Favorable Prognostic Factor ◽

Mobile Tongue

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Vascular rings and slings: A challenging diagnostic and therapeutic rare disease entity

Journal of the Egyptian Society of Cardio-Thoracic Surgery ◽

10.1016/j.jescts.2017.10.002 ◽

2017 ◽

Vol 25 (4) ◽

pp. 349-355

Author(s):

Yasser Mohamed Menaissy ◽

Mohamed –Adel Fetouh Elgamal ◽

Samy Amin ◽

Ahmed Fayez Zaki

Keyword(s):

Rare Disease ◽

Disease Entity ◽

Vascular Rings

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Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy

Radiation Oncology ◽

10.1186/1748-717x-5-43 ◽

2010 ◽

Vol 5 (1) ◽

pp. 43 ◽

Cited By ~ 65

Author(s):

Su Jung Shim ◽

Jihye Cha ◽

Woong Sub Koom ◽

Gwi Eon Kim ◽

Chang Geol Lee ◽

...

Keyword(s):

Cancer Patients ◽

Clinical Outcomes ◽

Tongue Cancer ◽

Postoperative Radiotherapy ◽

Oral Tongue ◽

Oral Tongue Cancer

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Nitroprusside Treatment of Erythromelalgia in an Adolescent Female

Annals of Pharmacotherapy ◽

10.1177/106002809703100513 ◽

1997 ◽

Vol 31 (5) ◽

pp. 590-592 ◽

Cited By ~ 16

Author(s):

Jonathan D Stone ◽

Michael P Rivey ◽

Douglas R Allington

Keyword(s):

Rare Disease ◽

Pediatric Patients ◽

Aspirin Therapy ◽

Adolescent Female ◽

Adolescent Patient ◽

Disease Entity ◽

Case Summary ◽

First Choice

OBJECTIVE: TO report a case of erythromelalgia in an adolescent patient successfully treated with nitroprusside. CASE SUMMARY: A 15-year-old girl with erythromelalgia resistant to aspirin therapy received an infusion of nitroprusside. The response of the erythromelalgia to nitroprusside was dramatic, with complete pain resolution within 17 hours after the start of therapy. No relapse of erythromelalgia was seen when nitroprusside was discontinued and the patient remained well after 6 months. DISCUSSION: This case adds to existing literature substantiating the benefit of nitroprusside for the treatment of erythromelalgia in pediatric patients. Erythromelalgia in children may represent a different disease entity than that seen in adults, which is commonly responsive to aspirin therapy. The pathogenesis of erythromelalgia is unclear and precludes formulating a proposed mechanism by which nitroprusside has benefit in children. CONCLUSIONS: Nitroprusside is valuable for erythromelalgia resistant to aspirin therapy in pediatric patients. Because of unanswered questions regarding the disease, aspirin remains the agent of first choice in all patients with this rare disease.

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