scholarly journals Pattern of lymph node metastasis in supraglottic carcinoma

1970 ◽  
Vol 17 (2) ◽  
pp. 110-116
Author(s):  
MA Quayum ◽  
AHMZ Huq ◽  
KH Tarafder
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Histopathological Examination ◽  
Regional Lymph Node ◽  
Glottic Carcinoma ◽  
Female Ratio ◽  
Presenting Symptoms ◽  
Node Metastasis ◽  
Supraglottic Carcinoma ◽  
Number Of Patients

Objectives: To find out the frequency and distribution of lymph node metastasis in supraglottic carcinoma. Study Design: Cross sectional study. Methods: 50 cases are included in this study (male-45 and female-5) between the ages of 40- 80 years who were treated from September 2007 to February 2008. Study based on history, clinical, radiological, laboratory and histopathological examination. Results: Highest number of patients was in the age group 50-60 years. Male and female ratio was 9:1. Commonest occupational group was cultivators and most patients come from poor socio-economic class. Smoking was commonest (70%).Out of 50 patients 20 (40%) had their regional lymph node involved. Level-II lymph nodes were involved in higher number of cases. Nodes in advanced stage of involvement were found in most cases. Homolateral involvement of nodes was in most cases (84.21%). Most of the patients present with more than one symptom and the commonest presenting symptoms of supraglottic carcinoma was cough and irritation (90%) followed by dysphagia (76%) and change of voice (72%). Most of the supraglottic growth was exophytic in appearance. The common site involve (50%) in the study were aryepiglottic fold and arytenoids. 80% of patients were present with T2 tumours. Patients were staged according to the TNM feature. Most of the patients (40%) were in stage-III followed by stage-II (24%). Conclusion: Lymphadenopathy is present much higher frequency in supraglottic carcinoma than glottic carcinoma. Key words: Supraglottic Carcinoma; Lymph node DOI: http://dx.doi.org/10.3329/bjo.v17i2.8850 BJO 2011; 17(2): 110-116

scholarly journals Frequency of Lympnode Metastasis in Supraglottic Ca Larynx

2019 ◽  
Vol 31 (2) ◽  
pp. 72-75
Author(s):  
Mohammad Rokan Uddin Bhuiyan ◽  
Mohammad Idris Ali ◽  
Balayet Hossain Siddiquee ◽  
Fatema Johora ◽  
Mohammad Kamal Hossain
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cervical Lymphadenopathy ◽  
Female Ratio ◽  
Node Metastasis ◽  
T Stage ◽  
Supraglottic Carcinoma ◽  
Level Ii ◽  
Number Of Patients ◽  
Carcinoma Of Larynx

Introduction: To observe the association between the level of lymph node metastasis and the T- stage and to evaluate the N- stage in supraglottic carcinoma of larynx. Materials and Methods: A prospective cross-sectional study was carried out on 80 consecutive cases of supraglottic carcinoma larynx in three tertiary level hospital in Dhaka during July'2009 to March 2011. Results: The highest number of patients were in the age group 5th and 6th decades. Male to female ratio was 9:1. Topographically 70 cases (87.5%) had lesions involving epiglottis, 5 cases (6.25%) in aryepiglottic fold and 5 cases (6.25%) had lesions at false cord. Majority cases were histopathologically confirmed squamous cell carcinoma (95%) and among them 46 cases (57.5%) had well differentiated. Cervical metastatic lymph nodes were found 40% (32 cases) where level-II was most common. This was most frequent in early supraglottic(T1&T2) carcinoma of larynx (86.25%), P=0.008. A positive correlation was found between the T stage of primary tumours and frequency of cervical lymphadenopathy. Lymph node metastasis were 4.77% in T1, 37.50% in T2, 71.43% in T3 and 91.67% in T4. In early stage lymph node involved 93.75% in Level- II, 6.25% in Level- III & in advanced stage 100% in Level - II, 62.5% in Level - III and 25.0% in Level - IV. Distribution of study cases (31.25%) in stage-II, 25% in stage-I, 22.50% in stage-Ill and 21.25% were in stage-IV. Conclusion: Result of this study may help the clinician for planning of treatment of this malignant diseases as well awareness. Medicine Today 2019 Vol.31(2): 72-75

EVALUATION OF CLINICAL AND PARACLINICAL FEATURES IN PATIENTS WITH CARCINOMA OF ORAL CAVITY

2016 ◽  
pp. 56-60
Author(s):  
Van Minh Nguyen ◽  
Hong Loi Nguyen ◽  
Thi Kim Anh Dang
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Tumor Size ◽  
Regional Lymph Node ◽  
Regional Lymph Node Metastasis ◽  
Female Ratio ◽  
Histopathological Grade ◽  
Node Metastasis ◽  
Metastasis Rate

Background: To evaluate the clinical, hystopathologycal features and correlation between lymph node metastasis and hystopathologycal grade in patients with carcinoma of the oral cavity. Materials and Methods: From July 2015 to July 2016, 32 patients with carcinoma of the oral cavity at Hue Central Hospital Results: The most common age group from 51 to 60 years and the male/female ratio was 1.9/1. Tumor were usually observed around the the tongue (40.6%) and oral floor (34.4%). Most of the tumor size is larger than 2 cm diameters (> 80%). The regional lymph node metastasis rate was 43.8% and there was a positive correlation between lymph node metastasis and tumor size (p <0.05). Squamous-cell carcinoma was mainly type of histopathology. Difference between the rate of lymph node metastasis in patient groups with different histopathological grade show no statistical significance (p> 0.05). Conclusion: the greater tumor, the higher regional lymph node metastasis. There is no relationship between the lymph node metastasis rate and histopathological grade of oral carcinoma. Key words: : carcinoma of oral cavity, tumor size, lymph node metastasis, histopathology

Parosteal (Juxtacortical) Chondrosarcoma of the Humerus Associated With Regional Lymph Node Metastasis

1993 ◽  
Vol &NA; (290) ◽  
pp. 168???173 ◽  
Author(s):  
KEIJI MATSUMOTO ◽  
SINSUKE HUKUDA ◽  
MICHIHITO ISHIZAWA ◽  
YASUO SARUHASHI ◽  
HIDETOSHI OKABE ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Regional Lymph Node ◽  
Regional Lymph Node Metastasis ◽  
Node Metastasis

Methylation profiles of genes in breast cancer luminal HER2-negative primary tumor during regional lymphnode metastasis

2021 ◽  
Vol 67 (1) ◽  
pp. 88-94
Author(s):  
A.M. Krasnyi ◽  
S.V. Kurevlev ◽  
A.A. Sadekova ◽  
T.G. Sefikhanov ◽  
V.V. Kometova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Regional Lymph Node ◽  
Statistical Significance ◽  
Aberrant Methylation ◽  
Primary Tumors ◽  
Node Metastasis ◽  
Lymphnode Metastasis ◽  
Node Metastases

Aberrant methylation is strongly associated with development of cancer, but limited data exist on correlation between methylation and regional lymph node metastasis (RLNM). The aim of this research was to study using of methylation levels of WIF1, RASSF1A, CDO1 and MEST aberrant methylated genes in a primary breast cancer for prediction of regional lymph node metastases. We used MS-HRM (Methylation Sensitive High Resolution Melting) to assess methylation levels. The results were confirmed by pyrosequencing. The study included 66 women with LumA and 46 women with HER2- (LumB-), 22 and 26 of them had metastasis in at least one lymph node respectively. It was found that methylation levels between LumA and LumB subtypes differed significantly in genes: WIF1 (p<0.001), CDO1 (p=0.002) and MEST (p=0.033). In the Lum A subtype statistically significant differences in level of methylation of WIF1 gene between patients with metastases in RLNM and patients without metastases were found (p=0.03). Analysis of tumors longer than 2 cm in the LumA subtype, revealed an increase of statistical significance of WIF1 gene — p=0.009 (AUC (95%CI) = 0.76 (0.59−0.93)). In LumB- subtype RASSF1A, CDO1 and MEST had statistically significant differences in methylation level between groups (p=0.03, p=0.048 and p=0.045 respectively). ROC analysis showed that combining of three genes by logistic regression, AUC (95%CI) was 0.74 (0.6−0.88). Analysis of tumors longer than 2 cm, did not increase statistical significance for these genes (p=0.046; p=0.089 and p=0.076, respectively). Thus, the study of methylation in primary tumors may be useful for prediction of lymph node metastasis, as well as for better understanding of biological process inside breast cancer.

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