scholarly journals Frequency of Lympnode Metastasis in Supraglottic Ca Larynx

2019 ◽  
Vol 31 (2) ◽  
pp. 72-75
Author(s):  
Mohammad Rokan Uddin Bhuiyan ◽  
Mohammad Idris Ali ◽  
Balayet Hossain Siddiquee ◽  
Fatema Johora ◽  
Mohammad Kamal Hossain
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cervical Lymphadenopathy ◽  
Female Ratio ◽  
Node Metastasis ◽  
T Stage ◽  
Supraglottic Carcinoma ◽  
Level Ii ◽  
Number Of Patients ◽  
Carcinoma Of Larynx

Introduction: To observe the association between the level of lymph node metastasis and the T- stage and to evaluate the N- stage in supraglottic carcinoma of larynx. Materials and Methods: A prospective cross-sectional study was carried out on 80 consecutive cases of supraglottic carcinoma larynx in three tertiary level hospital in Dhaka during July'2009 to March 2011. Results: The highest number of patients were in the age group 5th and 6th decades. Male to female ratio was 9:1. Topographically 70 cases (87.5%) had lesions involving epiglottis, 5 cases (6.25%) in aryepiglottic fold and 5 cases (6.25%) had lesions at false cord. Majority cases were histopathologically confirmed squamous cell carcinoma (95%) and among them 46 cases (57.5%) had well differentiated. Cervical metastatic lymph nodes were found 40% (32 cases) where level-II was most common. This was most frequent in early supraglottic(T1&T2) carcinoma of larynx (86.25%), P=0.008. A positive correlation was found between the T stage of primary tumours and frequency of cervical lymphadenopathy. Lymph node metastasis were 4.77% in T1, 37.50% in T2, 71.43% in T3 and 91.67% in T4. In early stage lymph node involved 93.75% in Level- II, 6.25% in Level- III & in advanced stage 100% in Level - II, 62.5% in Level - III and 25.0% in Level - IV. Distribution of study cases (31.25%) in stage-II, 25% in stage-I, 22.50% in stage-Ill and 21.25% were in stage-IV. Conclusion: Result of this study may help the clinician for planning of treatment of this malignant diseases as well awareness. Medicine Today 2019 Vol.31(2): 72-75

scholarly journals Pattern of lymph node metastasis in supraglottic carcinoma

1970 ◽  
Vol 17 (2) ◽  
pp. 110-116
Author(s):  
MA Quayum ◽  
AHMZ Huq ◽  
KH Tarafder
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Histopathological Examination ◽  
Regional Lymph Node ◽  
Glottic Carcinoma ◽  
Female Ratio ◽  
Presenting Symptoms ◽  
Node Metastasis ◽  
Supraglottic Carcinoma ◽  
Number Of Patients

Objectives: To find out the frequency and distribution of lymph node metastasis in supraglottic carcinoma. Study Design: Cross sectional study. Methods: 50 cases are included in this study (male-45 and female-5) between the ages of 40- 80 years who were treated from September 2007 to February 2008. Study based on history, clinical, radiological, laboratory and histopathological examination. Results: Highest number of patients was in the age group 50-60 years. Male and female ratio was 9:1. Commonest occupational group was cultivators and most patients come from poor socio-economic class. Smoking was commonest (70%).Out of 50 patients 20 (40%) had their regional lymph node involved. Level-II lymph nodes were involved in higher number of cases. Nodes in advanced stage of involvement were found in most cases. Homolateral involvement of nodes was in most cases (84.21%). Most of the patients present with more than one symptom and the commonest presenting symptoms of supraglottic carcinoma was cough and irritation (90%) followed by dysphagia (76%) and change of voice (72%). Most of the supraglottic growth was exophytic in appearance. The common site involve (50%) in the study were aryepiglottic fold and arytenoids. 80% of patients were present with T2 tumours. Patients were staged according to the TNM feature. Most of the patients (40%) were in stage-III followed by stage-II (24%). Conclusion: Lymphadenopathy is present much higher frequency in supraglottic carcinoma than glottic carcinoma. Key words: Supraglottic Carcinoma; Lymph node DOI: http://dx.doi.org/10.3329/bjo.v17i2.8850 BJO 2011; 17(2): 110-116

EVALUATION OF CLINICAL AND PARACLINICAL FEATURES IN PATIENTS WITH CARCINOMA OF ORAL CAVITY

2016 ◽  
pp. 56-60
Author(s):  
Van Minh Nguyen ◽  
Hong Loi Nguyen ◽  
Thi Kim Anh Dang
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Tumor Size ◽  
Regional Lymph Node ◽  
Regional Lymph Node Metastasis ◽  
Female Ratio ◽  
Histopathological Grade ◽  
Node Metastasis ◽  
Metastasis Rate

Background: To evaluate the clinical, hystopathologycal features and correlation between lymph node metastasis and hystopathologycal grade in patients with carcinoma of the oral cavity. Materials and Methods: From July 2015 to July 2016, 32 patients with carcinoma of the oral cavity at Hue Central Hospital Results: The most common age group from 51 to 60 years and the male/female ratio was 1.9/1. Tumor were usually observed around the the tongue (40.6%) and oral floor (34.4%). Most of the tumor size is larger than 2 cm diameters (> 80%). The regional lymph node metastasis rate was 43.8% and there was a positive correlation between lymph node metastasis and tumor size (p <0.05). Squamous-cell carcinoma was mainly type of histopathology. Difference between the rate of lymph node metastasis in patient groups with different histopathological grade show no statistical significance (p> 0.05). Conclusion: the greater tumor, the higher regional lymph node metastasis. There is no relationship between the lymph node metastasis rate and histopathological grade of oral carcinoma. Key words: : carcinoma of oral cavity, tumor size, lymph node metastasis, histopathology

scholarly journals Extent of neck dissection for patients with clinical N1 oral cancer

2020 ◽  
Vol 25 (6) ◽  
pp. 1067-1071 ◽  
Author(s):  
Yasumasa Kakei ◽  
Hirokazu Komatsu ◽  
Tsutomu Minamikawa ◽  
Takumi Hasegawa ◽  
Masanori Teshima ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cancer ◽  
Neck Dissection ◽  
Tongue Cancer ◽  
Positive Lymph Node ◽  
University Hospital ◽  
Oral Cancers ◽  
Node Metastasis ◽  
Level Ii

Abstract Background No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis. Patients Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I–V neck dissection as the initial treatment. Results None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II. Conclusions Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.

scholarly journals Prediction of Lymph Node Metastasis in Penile Cancer: Evaluation of Clinicopathological Factors, Validation of an Existing Model, and Development of Novel Nomogram

2021 ◽  
Author(s):  
Yanxiang Shao ◽  
Kan Wu ◽  
Thongher Lia ◽  
Xu Hu ◽  
Shangqing Ren ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Predictive Factors ◽  
Penile Cancer ◽  
Predictive Accuracy ◽  
External Validation ◽  
Nuclear Grade ◽  
Node Metastasis ◽  
T Stage ◽  
Younger Age

Abstract Objective To investigate the predictive factors of lymph node metastasis (LNM) and evaluate the usefulness of prediction nomograms. Methods This study analyzed data of 300 patients diagnosed with penile squamous cell carcinoma at West China Hospital (WCH) of Sichuan University (Chengdu, China) and 412 cases acquired from the Surveillance, Epidemiology, and End Results (SEER) program. Logistic regression analysis was performed on these cohorts to investigate the predictive factors of LNM. We evaluated a recently developed prediction nomogram for LNM, which was established based on the National Cancer Database (NCDB). Moreover, we developed a novel nomogram using cases from the WCH for the prediction of lymphatic metastasis. Results Logistic analysis identified that younger age at diagnosis, invasion of the penis body, poorer pT stage, cN stage, nuclear grade and the presence of lymph vascular invasion (LVI) were significantly correlated with LNM in WCH cases; however, only race, poorer T stage and cN stage were significantly associated with LNM among the cases from the SEER. Multivariate analysis demonstrated that younger age, poorer T stage, cN stage and nuclear grade were independent predictors of LNM. Receiver operating characteristic curve analysis of WCH cases showed that the tumor T stage 8th edition has better area under the curve than 7th stage (0.672 vs 0.636, respectively). Moreover, well AUC were seen in external validation of NCDB nomogram in WCH cohorts and SEER series (0.833 vs 0.795). The new nomogram included the aforementioned independent predictors and the bootstrap-corrected concordance was 0.876. Conclusion Younger diagnose age, poorer pT stage, cN stage, nuclear grade and LVI were the most important predictors of LNM in patients with penile cancer. 8th T stage performed better than 7th version in predicting LNM. NCDB nomogram have some application value in both WCH and SEER cases, and our novel model further improved the predictive accuracy.

scholarly journals Analysis of clinical and pathological factors in patients undergoing surgery for rectal cancer: a single-centre experience with 692 patients in China

2020 ◽  
Author(s):  
Liping Xu ◽  
Chi Zhang ◽  
Zhaoyue Zhang ◽  
Xinyu Tang ◽  
Qin Qin ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Perineural Invasion ◽  
Radical Surgery ◽  
Node Metastasis ◽  
T Stage ◽  
Significant Difference ◽  
Tumour Location ◽  
Poorly Differentiated

Abstract Background: The management of rectal carcinoma has substantially evolved over the past two decades, so as AJCC staging and NCCN guidelines. The inherent relationships of pathologic factors warrant further study. The present study aimed to assess the associations of clinical and pathological factors in rectal cancer patients undergoing radical surgery.Methods: From October 2015 to February 2019, all rectal cancer patients treated with radical surgery without neoadjuvant therapy were identified. The analysis was performed with data obtained from the prospectively collected database. Predictive factors for lymph node metastasis were analysed.Results: In total, 692 patients with a median age of 61.64 years (range: 22-89) were included. There was no significant difference in onset age between male and female patients (61.75±11.10 vs 61.43±11.92, P=0.723).Tumour location (P=0.004), perineural invasion (PNI) (P=0.000), lymphovascular invasion (LVI) (P=0.000), tumour deposit (TD) (P=0.000), and differentiation grade (P=0.000) were significantly related to pathologic T stage in univariate analysis, while sex was not (p=0.192).Compared to patients with T1 disease, there was a significantly higher proportion of positive LVI in patients with stage T3 disease (P=0.011, OR=3.404, 95% CI: 1.319-8.787) but not in those with T2 (P=0.686, OR=0.804, 95% CI: 0.280-2.310) and T4 (P=0.063, OR=3.200, 95% CI: 0.941-10.886) disease. Compared to patients with T2 disease, there was a significantly higher proportion of perineural invasion in patients with stage T3 (P=0.000, OR=6.2376, 95% CI: 3.371-11.685) but not T4 (P=0.172, OR=2.309, 95% CI: 0.694-7.676) disease. Compared to patients with T1 disease, a significantly higher proportion of TDs occurred in patients with stage T3 (P=0.013, OR=6.106, 95% CI: 1.455-25.631) and stage T4 (P=0.019, OR=7.146, 95% CI: 1.378-37.044) but not stage T2 (P=0.435, OR=0.503, 95% CI: 0.089-2.824) disease. The overall incidence of lymph node metastasis was 44.9% (19.6% for T1, 23.6% for T2, 56.7% for T3, and 67.8% for T4). Patient age, sex, and tumour location did not significantly affect lymph node metastasis (LNM). The presence of LVI (OR=3.882, 95% CI=2.338-6.440, P=0.000), TD (OR=27.645, 95% CI=9.805-77.947, P=0.000), higher T stage (OR=1.969, 95% CI=1.471-2.635, P=0.000), and poorly differentiated histology (OR=2.255, 95% CI=1.544-3.293, P=0.000) were associated with a higher incidence of LNM on multivariate analysis. Perineural invasion (P=0.000) significantly affected LNM in univariate but not multivariate analysis (OR=1.213, 95% CI=0.734-2.003, P=0.452).Conclusion: There was no significant difference between male and female patients in onset age. Tumour location, PNI, LVI, TD, and differentiation grade were significantly related to pathologic T stage. Patients with the presence of LVI and TD, higher T stage, and poorly differentiated histology have a significantly higher chance of LNM.

scholarly journals The immune checkpoint regulator PD-L1 expression are associated with clinical progression in prostate cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Juan He ◽  
Min Yi ◽  
Lingfeng Tan ◽  
Jianghua Huang ◽  
Lin Huang
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Gleason Score ◽  
Tumour Cells ◽  
Node Metastasis ◽  
T Stage ◽  
Positive Expression ◽  
Programmed Death ◽  
Programmed Death 1

Abstract Background The programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) have shown positive efficacy in several solid cancers due to their targeted antitumour effects. However, the frequency and clinical implication value in prostate cancer still remain unclear. Methods The PD-1/PD-L1 expression was detected by immunohistochemical (IHC) analysis in 96 retrospectively collected cases of prostatic cancer and 44 controls of benign prostatic hyperplasia (BPH). Its correlation with clinicopathological features including age, PSA level, Gleason score, lymph node metastasis, clinical T stage and risk factor grade in prostate cancer was also assessed. Results The PD-L1-positive expression was significantly higher in cancer cases compared with benign tissues, whereas no difference in PD-1 positive expression was found. Moreover, the PD-L1 expression in tumour cells or lymphocytes was associated with Gleason score, but not related to age, preoperative PSA level, clinical T-stage, lymph node metastasis and grade of risk factors. In addition, no association between the positive expression of PD-1 and PD-L1 in tumour cells and lymphocytes was found. Conclusions The expression of PD-L1 not PD-1 is highly prevalent in prostate cancer. PD-L1 is closely related to Gleason score and may be a co-factor associated with the progression of prostate cancer.

Exploration of the expression and significance of IL-6, STAT3 and PD-L1 in esophageal squamous cell carcinoma.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16554-e16554
Author(s):  
Yicheng Zhou ◽  
Honglei Zhu ◽  
Xuezhou Pang ◽  
Yang Shen ◽  
Yu He ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Stage ◽  
Tumor Diameter ◽  
Tumor Site ◽  
Positive Correlation ◽  
Normal Tissues ◽  
Node Metastasis ◽  
T Stage ◽  
Maximum Tumor Diameter

e16554 Background: Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide and has a very high morbidity and mortality rate. The IL-6/STAT3 axis can simultaneously promote the expansion of immunosuppressive cells.This study detected IL-6, STAT3 and PD-L1 in ESCC and analyzed the potential clinical application value. Methods: Between July 2018 and April 2019, 70 ESCC patients underwent radical thoracic surgery at Affiliated Hospital of North Sichuan Medical College. RT-PCR was used to detect PD-L1, IL-6, and STAT3 mRNA expression in cancer and adjacent normal tissues. Western blot detection of PD-L1, IL-6, and STAT3 was performed in 40 cancer and adjacent normal tissues. The correlation of PD-L1, IL-6 and STAT3 protein expression with tumor invasion depth, tumor size, lymph node metastasis,clinical stage and other clinicopathological characteristics as well as the correlation between the three proteins were analyzed statistically. Results: The mRNA levels of PD-L1, IL-6, and STAT3 in 70 ESCC patients were significantly different between cancerous and adjacent normal tissues (P < 0.001). In 40 ESCC patients, 28 ESCC tissues showed significantly higher PD-L1 expression than adjacent normal tissue (28/12, P < 0.001), 29 ESCC tissues showed significantly higher STAT3 expression (29/11,P = 0.009 ), and 27 ESCC tissues showed significantly higher IL-6 expression (27/13,P = 0.042). There was no correlation between PD-L1 expression and age, sex, tumor site or maximum tumor diameter, but PD-L1 expression showed a positive correlation with T stage (P = 0.009), lymph node metastasis (P = 0.044), and clinical stage (P = 0.033). There was no correlation between STAT3 expression and age, sex, tumor site, maximum tumor diameter, lymph node metastasis or clinical stage, but STAT3 expression showed a positive correlation with T stage (P = 0.025). IL-6 expression was not correlated with age, sex, maximum tumor diameter, lymph node metastasis or clinical stage, but IL-6 expression showed a positive correlation with T stage ( P = 0.003)and tumor site (P = 0.011). In addition, PD-L1 expression showed a positive correlation with STAT3 (P = 0.013) and IL-6 ( P = 0.008), and STAT3 showed a positive correlation with IL-6 ( P = 0.027). Conclusions: PD-L1, IL-6, and STAT3 are highly expressed in ESCC and their protein levels exhibit a positive correlation. The IL-6/STAT3 signaling pathway proteins may be a potential biomarker predicting the efficacy of immunotherapy by affecting the expression of PD-L1.

scholarly journals Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma

2019 ◽  
Vol 10 (12) ◽  
Author(s):  
Pei Li ◽  
Xi-Jun Lin ◽  
Yang Yang ◽  
An-Kui Yang ◽  
Jin-Ming Di ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Clinical Stage ◽  
Reciprocal Regulation ◽  
Node Metastasis ◽  
T Stage

AbstractThe burgeoning functions of many microRNAs (miRs) have been well study in cancer. However, the level and function of miR-1205 in laryngeal squamous cell cancer remains unknown. In the current research, we validated that miR-1205 was notably downregulated in human laryngeal squamous cell carcinoma (LSCC) samples in comparison with tissues adjacent to LSCC, and correlated with T stage, lymph node metastasis, and clinical stage. Using Kaplan–Meier analysis indicates that high expression of miR-1205 has a favorable prognosis for patients with LSCC. Functional assays show that enforced miR-1205 expression attenuates the migration, growth, and invasion of LSCC cells. And E2F1 is verified to be a target of miR-1205, while E2F1 binds to miR-1205 promoter and transcriptionally inhibits miR-1205 expression. Overexpression of E2F1 reverses the inhibitory impacts of miR-1205 on LSCC cells in part. Importantly, E2F1 is abnormally increased in LSCC tissues, and its protein levels were inversely relevant to miR-1205 expression. High E2F1 protein level is in connection with clinical stage, T stage, lymph node metastasis, and poor prognosis. Consequently, reciprocal regulation of miR-1205 and E2F1 plays a crucial role in the progression of LSCC, suggesting a new miR-1205/E2F1-based clinical application for patients of LSCC.

scholarly journals Clinicopathological Study of Supraglottic Carcinoma of Larynx

2020 ◽  
Vol 15 (2) ◽  
pp. 224-226
Author(s):  
Md Monsur Alam ◽  
Md Zakir Hossain ◽  
Mohd Shamim Bin Shaid Khan
Keyword(s):  
Age Groups ◽  
Neck Surgery ◽  
Lymph Node Involvement ◽  
Military Hospital ◽  
Early Presentation ◽  
Female Ratio ◽  
T2 Lesions ◽  
Supraglottic Carcinoma ◽  
Number Of Patients ◽  
Carcinoma Of Larynx

Introduction: Incidence of supraglottic carcinoma is more common which may be related to poor nutrition with personal habit like smoking and chewing habit of betel leaves with various ingredient. Objectives: To find out the incidence, age and sex distribution, occupation and clinical presentation of supraglottic carcinoma of larynx. Materials and Methods: In this prospective study, 30 patients of supraglottic carcinoma are collected from department of ENT and Head-Neck surgery, Combined Military Hospital, Dhaka from July 2012 to July 2013. Results: Patients belongs to different age groups, ranging from 40 to 80 years and maximum patients are in 50 to 60 years of age. The male to female ratio is 5:1. In this series, majority of patients are smoker (66.66%). Most of them are from low socio-economic group. The incidence of lymph node involvement is 40% (12 cases). Maximum number of patients presents with exophytic lesion (60%). Ulcerative lesions are 26.66% and infiltrative lesions are 13.33%. Maximum numbers of patients have T2 lesions (80%). T1 lesions are 20%. In this study all cases are histopathologically confirmed to be squamous cell carcinoma (100%). In this study, all cases are M0 state. Conclusion: Supraglottic carcinoma occurs between 40-80 years of age, more common in 5th and 6th decades. Chewing betel nut and tobacco should be avoided to reduce the risk of supraglottic carcinoma and early presentation & diagnosis will improve the prognosis of patients. JAFMC Bangladesh. Vol 15, No 2 (December) 2019: 224-226

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