scholarly journals Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition

2015 ◽  
Vol 10 (2) ◽  
pp. 267 ◽  
Author(s):  
Meng Hang ◽  
Fan Zhao ◽  
Shu-Bo Chen ◽  
Qing Sun ◽  
Chun-Xiao Zhang
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Dependent Manner ◽  
Small Cell Lung ◽  
Mesenchymal Transition

<p>The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer.</p><p> </p><p> </p>

scholarly journals Knockdown of 14-3-3γ Suppresses Epithelial–Mesenchymal Transition and Reduces Metastatic Potential of Human Non-small Cell Lung Cancer Cells

2018 ◽  
Vol 38 (6) ◽  
pp. 3507-3514 ◽  
Author(s):  
PRITSANA RAUNGRUT ◽  
ANUSARA WONGKOTSILA ◽  
NIDANUT CHAMPOOCHANA ◽  
KRIENGSAK LIRDPRAPAMONGKOL ◽  
JISNUSON SVASTI ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Metastatic Potential ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Mesenchymal Transition

scholarly journals CTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0198823 ◽  
Author(s):  
Xiangdong Lu ◽  
Juan Gao ◽  
Yao Zhang ◽  
Tao Zhao ◽  
Hongchuan Cai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Mesenchymal Transition

scholarly journals The Root Bark of Morus alba L. Suppressed the Migration of Human Non-Small-Cell Lung Cancer Cells through Inhibition of Epithelial–Mesenchymal Transition Mediated by STAT3 and Src

2019 ◽  
Vol 20 (9) ◽  
pp. 2244 ◽  
Author(s):  
Tae-Rin Min ◽  
Hyun-Ji Park ◽  
Moon Nyeo Park ◽  
Bonglee Kim ◽  
Shin-Hyung Park
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Root Bark ◽  
Small Cell Lung ◽  
Mesenchymal Transition

The root bark of Morus alba L. (MA) has been traditionally used for the treatment of various lung diseases in Korea. Although recent research has demonstrated its anticancer effects in several cancer cells, it is still unclear whether MA inhibits the migratory ability of lung cancer cells. The present study investigated the effects of MA on the migration of lung cancer cells and explored the underlying mechanism. Results from a transwell assay and wound-healing assay demonstrated that methylene chloride extracts of MA (MEMA) suppressed the migration and invasion of H1299, H460, and A549 human non-small-cell lung cancer (NSCLC) cells in a concentration-dependent manner. Results from Western blot analyses showed that MEMA reduced the phosphorylation of STAT3 and Src. In addition, MEMA downregulated the expression of epithelial–mesenchymal transition (EMT) marker proteins including Slug, Snail, Vimentin, and N-cadherin, while upregulating the expression of Occludin—a tight-junction protein. The regulation of EMT markers and the decrease of migration by MEMA treatment were reversed once phospho-mimetic STAT3 (Y705D) or Src (Y527F) was transfected into H1299 cells. In conclusions, MEMA inhibited the migratory activity of human NSCLC cells through blocking Src/STAT3-mediated EMT.

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