scholarly journals Serum lactate dehydrogenase level in childhood acute lymphoblastic leukemia

2008 ◽  
Vol 33 (3) ◽  
pp. 88-91 ◽  
Author(s):  
Md Golam Hafiz ◽  
MA Mannan
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lactate Dehydrogenase ◽  
Lymphoblastic Leukemia ◽  
Lactate Dehydrogenase Level ◽  
Serum Lactate ◽  
Significant Rise ◽  
Serum Lactate Dehydrogenase ◽  
Childhood All ◽  
Response To Chemotherapy ◽  
Wbc Count

Serum lactate dehydrogenase (LDH) level was estimated in 44 childhood (age range 1-15 years) acute lymphoblastic leukemia (ALL) on admission, day 14 and day 29 of induction. Another 25 children without ALL were included as control. On admission, the level of serum LDH was significantly high in ALL cases than control (p<0.001). Total WBC count was significantly decreased along with serum LDH level at day 14 and day 29 of induction (p<0.001). A significant rise of platelet count was observed at day 29 of induction in relation to significant decrease of serum LDH level (p<0.001). A significant decrease of peripheral and bone marrow blast cell percentages were also observed at day 29 of induction along with significant decrease level of serum LDH (p<0.001). So, the measurement of serum LDH level can be accepted as an enzymatic tool for presumption of childhood ALL and the response to chemotherapy during induction of remission.DOI = 10.3329/bmrcb.v33i3.1139Bangladesh Med Res Counc Bull 2007; 33: 88-91

scholarly journals Value of Serum Lactate Dehydrogenase Level in the Detection of Hemato-oncological Malignancies and its Response to Induction in Childhood Acute Lymphoblastic Leukemia

1970 ◽  
pp. 1-6
Author(s):  
Golam Hafiz ◽  
Abdul Mannan ◽  
Afiqul Islam ◽  
Matiur Rahman ◽  
Atiar Rahman ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lactate Dehydrogenase ◽  
Lymphoblastic Leukemia ◽  
Hematological Parameters ◽  
Lactate Dehydrogenase Level ◽  
Serum Lactate ◽  
Significant Rise ◽  
Serum Lactate Dehydrogenase ◽  
Childhood All ◽  
Wbc Count

Serum lactate dehydrogenase (LDH) level was estimated in 77 childhood (age range 1- 15 years) hemato-oncological malignancies: acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), Hodgkin's disease (HD) and Non- Hodgkin's lymphoma (NHL) on admission. Serum LDH level was also measured in ALL on day 14 and day 29 of induction. Another 25 children without hemato-oncological malignancies were included as control. On admission, the level of serum LDH was significantly raised in all hematooncological malignancies but the levels was highly significant in ALL than control (p<0.001). Total WBC count was significantly decreased along with serum LDH level on day 14 and day 29 of induction (p<0.001). A significant rise of platelet count was observed on day 29 of induction in relation to significant decrease of serum LDH level (p<0.001). Significant decrease of peripheral and bone marrow blast cell percentages were also observed on day 29 of induction along with significant decrease level of serum LDH (p<0.001). It is observed in this study that serum LDH level was significantly elevated in all hemato-oncological malignancies on admission but the levels were highly significant in ALL patients. Following induction of remission in ALL, level of serum LDH was decreased along with the return of hematological parameters towards normal. So, the measurement of serum LDH level can be accepted as a predictor in diagnosis of hemato-oncological malignancies and prognosis of childhood ALL. Key words: Serum lactate dehydrogenase (LDH); Hemato-oncological malignancies; Induction; Acute lymphoblastic leukemia (ALL). DOI: 10.3329/bjch.v30i1.6175 Bangladesh J Child Health 2006; VOL 30 (1/2/3) : 1-6

Serum Lactate Dehydrogenase Level in Patients with Nasopharyngeal Carcinoma

1997 ◽  
Vol 36 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Chuang-Chi Liaw ◽  
Cheng-Hsu Wang ◽  
Jen-Sheng Huang ◽  
Mee-Chou Kiu ◽  
Jen-Shi Chen ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Nasopharyngeal Carcinoma ◽  
Lactate Dehydrogenase Level ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Serum Lactate Dehydrogenase Level

scholarly journals Can Serum Lactate Dehydrogenase Level be Used for Predicted to IPF Clinical Severity?

2019 ◽  
Vol 20 (-1) ◽  
pp. 158-158
Author(s):  
Elif Yelda Niksarlioglu ◽  
◽  
Gungor Camsari ◽  
Mehmet Atilla Uysal ◽  
Emel Tas ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Lactate Dehydrogenase Level ◽  
Serum Lactate ◽  
Clinical Severity ◽  
Serum Lactate Dehydrogenase ◽  
Serum Lactate Dehydrogenase Level

scholarly journals In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia

Blood ◽  
1995 ◽  
Vol 86 (10) ◽  
pp. 3861-3868 ◽  
Author(s):  
E Klumper ◽  
R Pieters ◽  
AJ Veerman ◽  
DR Huismans ◽  
AH Loonen ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Acute Lymphoblastic Leukemia ◽  
Poor Prognosis ◽  
De Novo ◽  
Lymphoblastic Leukemia ◽  
Childhood All ◽  
Acquired Drug Resistance ◽  
The Poor ◽  
Response To Chemotherapy

Cellular drug resistance is thought to be an important cause of the poor prognosis for children with relapsed or refractory acute lymphoblastic leukemia (ALL), but it is unknown when, to which drugs, and to what extent resistance is present. We determined in vitro resistance to 13 drugs with the MTT assay. Compared with 141 children with initial ALL, cells from 137 children with relapsed ALL were significantly more resistant to glucocorticoids, L-asparaginase, anthracyclines, and thiopurines, but not to vinca-alkaloids, cytarabine, ifosfamide, and epipodophyllotoxins. Relapsed ALL cells expressed the highest level of resistance to glucocorticoids, with a median level 357- and >24-fold more resistant to prednisolone and dexamethasone, respectively, than initial ALL cells, whereas the resistance ratios for the other drugs differed from 0.8- to 1.9-fold, intraindividual comparisons between initial and relapsed samples from 16 children with ALL showed that both de novo and acquired drug resistance were involved. Specific in vitro drug-resistance profiles were associated with high-risk relapsed ALL groups. In vitro drug resistance was also related to the clinical response to chemotherapy in relapsed/refractory childhood ALL. We conclude that drug resistance may explain the poor prognosis for children with relapsed/refractory ALL. These day may be helpful to design alternative treatment regimens for relapsed childhood ALL.

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