The Association between Serum Lactate Dehydrogenase Level and In-hospital Death due to Pulmonary Embolism

Background: Few studies are evaluating the prognostic value of lactate dehydrogenase (LDH) in patients with pulmonary embolism (PE). We analyzed the possible power of serum LDH levels to predict in-hospital mortality.Methods: In this cross-sectional study 217 patients with confirmed PE diagnosis with CT angiography and available serum LDH level at first 24-hours upon admission were included.Results: The mean age of patients was 63.04±16.81 years old, 23 patients (10.6%) died during hospitalization. Multivariate analysis showed that only LDH, WBC were independent predictors of in-hospital mortality, however, this association was not significant.Conclusion: LDH can be a good prognostic marker for predicting in-hospital death in patients with pulmonary embolism.

The relationship between serum lactate dehydrogenase level and mortality in critically ill patients

Background: To assess the association between serum lactate dehydrogenase (LDH) levels and mortality in intensive care unit patients. Materials & methods: A total of 1981 patients in the eICU Collaborative Research Database were divided into four groups according to quartiles of LDH levels. Logistic regressions were performed. Results: Elevated LDH levels were significantly associated with higher mortality (intensive care unit mortality: Q2 vs Q1: 1.046 [0.622–1.758]; Q3 vs Q1: 1.667 [1.029–2.699]; and Q4 vs Q1: 1.760 [1.092–2.839]). Similar results persisted in patients with different acute physiology and chronic health evaluation IV scores, and with or without sepsis. Conclusion: The serum LDH level may aid in the early identification of mortality risk in critically ill patients.

The Association Between Serum Lactate Dehydrogenase Level and in-hospital Death Due to Pulmonary Embolism

Background: There are few studies evaluating the prognostic value of lactate dehydrogenase (LDH) in patients with pulmonary embolism (PE). We analyzed possible power of serum LDH level to predict in-hospital mortality. Methods: In this cross-sectional study 217 patients with confirmed PE diagnosis with CT angiography and available serum LDH level at first 24-hours upon admission were included. Results: The mean age of patients were 63.04±16.81 years old, 23 patients (10.6%) died during hospitalization. Multivariate analysis showed that only LDH, WBC were independent predictors of in-hospital mortality, however this association was not significant. Conclusions: In patients with pulmonary embolism, LDH can be a good prognostic marker for predicting in-hospital death.