Evaluation of autogenous tooth transplantation for replacement of the missing or unrestorable mandibular molar tooth

<p>This study was undertaken to evaluate the functional and occlusal stability of autogenous tooth transplantation. A total of 30 patients were included. Among them, 21 participants received transplanted first molar and the remaining 9 received transplanted second molar. In all the cases, donor tooth were third molar. In each participant, extraction of un-restorable first or second molar tooth was performed which was then replaced by atrumatic extracted third molar tooth. Each third molar tooth was placed in the recipient extracted socket, followed by the evaluation of the occlusion and then stabilized with arch bar and ligature wire. Clinical follow-up evaluation was performed at 15 days, 3 and 12 months in respect to occlusal stability, tooth mobility and periodontal status. It was found that 23 transplanted tooth were successful and the remaining 7 tooth need long-term observation for the final outcome, which was statistically significant. It can be concluded that the autogenous tooth transplantation can replace missing tooth to ensure the preservation of function, aesthetic and to prevent bone resorption of the missing area of the jaw, which can lead to exceptional esthetic and functional outcome.</p>

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Long-Term Outcome of Autotransplantation of a Complete Root Formed a Mandibular Third Molar

Case Reports in Dentistry ◽

10.1155/2021/5512804 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Hiroyuki Kimura ◽

Yusuke Hamada ◽

Taro Eida ◽

Tsuyoshi Kumano ◽

Kazutoshi Okamura ◽

...

Keyword(s):

Case Report ◽

Donor Site ◽

Third Molar ◽

Recipient Site ◽

Extraction Area ◽

Long Term Outcome ◽

Second Molar ◽

Tooth Transplantation ◽

Mandibular Third Molar

Autogenous tooth transplantation is a procedure to reposition an autogenous tooth to another extraction area or surgically created recipient site. The autotransplantation procedures have been documented well in the literature, and the survival rate of the transplanted teeth was reported to be more than 90% after ten years. Therefore, autotransplantation might have been overlooked as a treatment option. The purpose of this case report is to evaluate the long-term (29-year) success and periodontal stability of the tooth autotransplantation from the mandibular third molar to the second molar. A 24-year old female presented to a clinic with a large caries lesion with periapical radiolucnecy on to tooth #18. The tooth was extracted with the site and treated with autogenous tooth transplantation from #17 with a complete root form. Endodontic treatment was completed 3 months post autotransplantation; the final prosthesis was placed 6 months postoperatively. The patient has shown excellent oral hygiene care and high compliance with the regular maintenance recall program. The transplanted tooth has been still functioning without any symptoms. Radiographic and clinical examinations revealed stable periodontal and endodontic conditions over the 29 years after the procedure. This case report showed the long-term success of autotransplantation of the mandibular third molar with a closed root apex to the second molar site. Autotransplantation can be an option when an adequate donor site is available to reconstruct the occlusion after the tooth extraction.

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Focal Palatitis (Previously Focal Palatine Erosions) in Captive Cheetahs (Acinonyx jubatus)

Frontiers in Veterinary Science ◽

10.3389/fvets.2021.682150 ◽

2021 ◽

Vol 8 ◽

Author(s):

Gerhard Steenkamp ◽

Sonja C. Boy ◽

Paul J. van Staden ◽

Marthán N. Bester

Keyword(s):

Molar Tooth ◽

Permanent Teeth ◽

Foreign Material ◽

Acinonyx Jubatus ◽

Inflammatory Lesions ◽

Skull Development ◽

Mandibular Molar ◽

Molar Teeth ◽

A Prospective Study

Focal palatine erosion (FPE) is a misleading term that is used in the literature to describe inflammatory lesions associated with depressions of the palatal mucosa in cheetah. Cheetahs have large cheek teeth and these depressions are formed to accommodate them. Previously FPE was only described as a mandibular molar tooth malocclusion on the hard palate due to suspected rotation and super eruption of the mandibular molar teeth of cheetahs aged 18 months and older. Two hundred and fifty six cheetahs (135 male, 121 female), originating from two independent facilities, had their oral cavities evaluated as part of an annual health visit over a decade. Ninety-nine cheetahs were seen once, 59 cheetahs were seen twice, 33 were seen three times, 43 on four occasions, 16 on five occasions, 5 on six occasions, and 1 cheetah was seen seven times. Apart from these clinical cases a prospective study on 5 cheetah cubs (3 male and 2 female) was conducted to document their skull development and mandibular molar tooth eruption over a period of 25 months. Of the 261 cheetahs observed none developed rotation or super eruption of their mandibular molar teeth. The term FPE is a misnomer as these inflammatory lesions were found in palatal depressions opposing any of the cusps of all of the cheetah mandibular cheek teeth. It consisted mainly of deep ulcerations, inflammation and oedema and also micro abscess formation. In severe cases oro-nasal fistulas were present. Of all the depressions present on the cheetah's palate, the large one palatal to the 4th maxillary premolar tooth was most commonly affected. In the five cubs evaluated prospectively, focal palatitis was evident from the 7 month evaluation, before all the permanent teeth erupted. Conservative treatment of the inflamed depressions by removing the foreign material through curettage and copious flushing reduced the grade of the inflammation when observed on follow-up. Focal palatine erosion is an incorrect term used to describe focal palatitis that occurs randomly in cheetahs. This focal palatitis is often associated with foreign material trapped in the palatal depressions. Conservative management is sufficient to treat these animals without odontoplasties.

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Long-term effectiveness and safety of antiepileptic drugs in children and adults

Reviews on Clinical Pharmacology and Drug Therapy ◽

10.17816/rcf192221-228 ◽

2021 ◽

Vol 19 (2) ◽

pp. 221-228

Author(s):

Roza M. Shaimardanova ◽

Rimma G. Gamirova

Keyword(s):

Valproic Acid ◽

Antiepileptic Drugs ◽

Focal Epilepsy ◽

City Hospital ◽

Long Term Follow Up ◽

Short And Long Term ◽

Long Term Observation ◽

Patients With Epilepsy

AIM: To conduct a retrospective comparative analysis of the efficacy and safety of epilepsy therapy with antiepileptic drugs. MATERIALS AND METHODS: The analysis of the treatment of 428 patients with epilepsy at the Childrens City Hospital No. 8 in Kazan, receiving antiepileptic drugs. RESULTS: It was found that valproic acid is more effective in the treatment of idiopathic generalized epilepsies compared to focal epilepsies (p = 0.0006). Valproate and carbamazepine were the most effective in the treatment of focal epilepsy with short- and long-term follow-up. Valproic acid is more effective than topiramate (p = 0.02), oxcarbazepine (p = 0.003), and levetiracetam (p = 0.003) in the treatment of focal epilepsy in short- and long-term follow-up. Carbamazepine is more effective than topiramate (p = 0.01), oxcarbazepine (p = 0.02), and levetiracetam (p = 0.001) in the treatment of focal epilepsy in long-term follow-up. It was revealed that more often they complained about side effects when using carbamazepine (63.2%). Levetiracetam was found to be better tolerated compared to valproate (p = 0.0006) and carbamazepine (p = 0.0006). Topiramate is better tolerated than carbamazepine (p = 0.02) and valproate (p = 0.03). Oxcarbazepine is better tolerated than carbamazepine in women (p = 0.04). CONCLUSIONS: When choosing an antiepileptic drug, it is necessary to be guided by the principle: first the basic, and then the drugs of the next generations, in the future, rely on information about the tolerability of the drug. It is necessary to evaluate the therapeutic effect of antiepileptic drugs with long-term observation, and use the criterion of complete absence of seizures as an indicator of the effectiveness of drugs.

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Post-natal Effect of Overexpressed DKK1 on Mandibular Molar Formation

Journal of Dental Research ◽

10.1177/0022034511421926 ◽

2011 ◽

Vol 90 (11) ◽

pp. 1312-1317 ◽

Cited By ~ 25

Author(s):

X.L. Han ◽

M. Liu ◽

A. Voisey ◽

Y.S. Ren ◽

P. Kurimoto ◽

...

Keyword(s):

Developmental Stages ◽

Formation Rate ◽

Third Molar ◽

Nestin Expression ◽

Second Molar ◽

Mandibular Molar ◽

Targeted Expression ◽

Enamel Knots ◽

Dentin Formation

Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction. Conversely, targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic development. However, its role in post-natal dentinogenesis is largely unknown. To address this issue, we studied the role of DKK1 in post-natal dentin development using 2.3-kb Col1a1- Dkk1 transgenic mice, with the following key findings: (1) The Dkk1 transgene was highly expressed in pulp and odontoblast cells during post-natal developmental stages; (2) the 1st molar displayed short roots, an enlarged pulp/root canal region, and a decrease in the dentin formation rate; (3) a small malformed second molar and an absent third molar; (4) an increase of immature odontoblasts, few mature odontoblasts, and sharply reduced dentinal tubules; and (5) a dramatic change in Osx and nestin expression. We propose that DKK1 controls post-natal mandibular molar dentin formation either directly or indirectly via the inhibition of Wnt signaling at the following aspects: (i) post-natal dentin formation, (ii) formation and/or maintenance of the dentin tubular system, (iii) mineralization of the dentin, and (iv) regulation of molecules such as Osx and nestin.

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The Criteria for Lower Second Molar Extraction

British Journal of Orthodontics ◽

10.1179/bjo.14.1.1 ◽

1987 ◽

Vol 14 (1) ◽

pp. 1-9 ◽

Cited By ~ 12

Author(s):

J. T. Dacre

Keyword(s):

Selection Criteria ◽

Third Molar ◽

Second Molar ◽

The Third ◽

The Right ◽

Molar Extraction

The benefits of lower second molar extraction are substantially reduced if the third molar fails to erupt into a satisfactory position. The selection criteria offered by the literature have been tested in a sample of 51 patients. Prediction is uncertain and cases should be followed until such time as a satisfactory third molar position has been achieved. Failure may be unilateral and more often on the right side. The need for follow-up treatment is subjective but may be as many as one in the patients.

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Long-Term Observation of Adolescents Initiating HAART Therapy: Three-Year Follow-Up

AIDS Research and Human Retroviruses ◽

10.1089/aid.2006.0290 ◽

2007 ◽

Vol 23 (10) ◽

pp. 1208-1214 ◽

Cited By ~ 45

Author(s):

Patricia M. Flynn ◽

Bret J. Rudy ◽

Jane C. Lindsey ◽

Steven D. Douglas ◽

Janet Lathey ◽

...

Keyword(s):

Long Term Observation ◽

Haart Therapy

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Intraoral third molar transplants: report of three cases and long-term follow-up

The Journal of the American Dental Association ◽

10.14219/jada.archive.1978.0322 ◽

1978 ◽

Vol 97 (3) ◽

pp. 486-490

Author(s):

Thaddeus G. Pantera ◽

Richard L. Pantera

Keyword(s):

Third Molar ◽

Long Term Follow Up

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Adrenal incidentaloma – diagnostic and treating problem – own experience

Open Medicine ◽

10.1515/med-2018-0043 ◽

2018 ◽

Vol 13 (1) ◽

pp. 281-284 ◽

Cited By ~ 1

Author(s):

Ryszard Pogorzelski ◽

Krzysztof Celejewski ◽

Sadegh Toutounchi ◽

Ewa Krajewska ◽

Tomasz Wołoszko ◽

...

Keyword(s):

Adrenal Tumor ◽

Ultrasound Examination ◽

Adrenal Incidentaloma ◽

Adrenal Tumors ◽

Hormonal Activity ◽

Imaging Studies ◽

Costs Of Treatment ◽

Long Term Observation

AbstractIntroductionIncidentaloma is defined as an tumor diagnosed accidentally using imaging studies performed due to other indications. The aim of this paper was to describe the diagnostic and treatment problems experienced by patients with adrenal incidentaloma in a clinical practice.Material and methodsIn years 2009-2012 there were 33(16,5%) adrenal tumors diagnosed incidentally out of 200 cases treated due to adrenal pathology. The group consisted of 54 patients aged 27-77. In 15(45,5%) patients the diagnosis was made based on ultrasound examination, while in 18(54,5%) the tumor was visualized in CT/MRI.ResultsOnly after the diagnostics was finalized, in which in all cases no signs of hormonal activity were detected, 26(78,8%) patients were qualified for the surgery. In 7(21,2%) cases no indications for such a management were found. The latter group was followed-up and in all patients the indications for the surgery arose due to enlargement of the tumor or/and the existence of hormonal activity. Our observations suggest that the incident finding of adrenal tumor is an indication of long-term observation. The analysis of our material shows that all patients observed needed surgical treatment.ConclusionsThe small adrenal tumors under follow-up have a tendency to enlarge and acquire hormonal activity. Long-term observation significantly increases the costs of treatment in that group, which eventually results in surgical management.

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