A Child with Ulcerative Colitis - A Case Report

Ulcerative colitis in children has not been reported previouslyin Bangladesh. This case report is of a 7 year old girl whopresented with frequent passage of slimy stool mixed with bloodfor 4 months. She also had fever, weight loss, abdominal painand urgency at defecation. Barium enema showed pancolitiswith multiple pseudopolyps and collar button appearance.Colonoscopy revealed a friable and granular mucosa withdiffuse ulceration and multiple pseudopolyps. There was bloodyexudate and the lumen was narrow. Histopathology findingsshowed necrosed tissue probably representing a base of ulcerand inflammatory cell infiltrate in the lamina propria. Thecrypt architecture was distorted with cryptitis and goblet celldepletion. There was no granuloma. She was diagnosed as acase of ulcerative colitis & treated with Sulfasalazine and oralcorticosteroid. Her response to treatment was very well andnow she is on regular follow up.DOI: 10.3329/jbcps.v28i2.5372J Bangladesh Coll Phys Surg 2010; 28: 117-120

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Phenotypic and functional characterization of intraepithelial and lamina propria inflammatory cell infiltrate in autoimmune enteropathy.

Frontiers in Immunology ◽

10.3389/conf.fimmu.2013.02.01175 ◽

2013 ◽

Vol 4 ◽

Author(s):

Paroni Moira ◽

Nizzoli Giulia ◽

Abrignani Sergio ◽

Geginat Jeans ◽

Caprioli Flavio

Keyword(s):

Lamina Propria ◽

Inflammatory Cell ◽

Functional Characterization ◽

Inflammatory Cell Infiltrate ◽

Cell Infiltrate ◽

Autoimmune Enteropathy

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Intestinal pathology associated with Trichostrongylus colubriformis infection in sheep: histology

Parasitology ◽

10.1017/s0031182000049623 ◽

1975 ◽

Vol 70 (2) ◽

pp. 165-171 ◽

Cited By ~ 38

Author(s):

I. K. Barker

Keyword(s):

Lamina Propria ◽

Inflammatory Cell ◽

Surface Epithelium ◽

Inflammatory Cell Infiltrate ◽

Polymorphonuclear Cells ◽

Cell Infiltrate ◽

Trichostrongylus Colubriformis ◽

Flat Surfaces ◽

Intestinal Pathology ◽

Superficial Epithelium

Observations were made on the histology of tissues from the first 6–10 m of the small intestine from both sheep infected with Trichostrongylus colubriformis and from uninfected controls. In uninfected animals, and in distal samples from infected lambs, villi were tall and covered by tall columnar epithelium, the intestinal crypts were convoluted and the lamina propria was only moderately cellular. In tissues with sub-total villus atrophy and a convoluted surface, the superficial epithelium was usually low columnar, often with an indistinct brush border. More severely affected mucosa was flat, with low surface epithelium and protruding crypt openings. The flat surfaces frequently had leaks of eosinophilic material and polymorphonuclear cells between enterocytes, or through erosions in the epithelium. Such defects were smaller and less frequent in mucosa with a convoluted surface. There were increased mitoses in intestinal crypts and a heavy inflammatory cell infiltrate in the lamina propria. Mast cell, globule leucocyte and theliolymphocyte numbers were not increased in infected sheep.

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P.05.9 PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF INTRAEPITHELIAL AND LAMINA PROPRIA INFLAMMATORY CELL INFILTRATE IN AUTOIMMUNE ENTEROPATHY

Digestive and Liver Disease ◽

10.1016/s1590-8658(13)60338-2 ◽

2013 ◽

Vol 45 ◽

pp. S121-S122

Author(s):

M. Paroni ◽

G. Nizzoli ◽

A. Magarotto ◽

U. Gianelli ◽

C. Ciafardini ◽

...

Keyword(s):

Lamina Propria ◽

Inflammatory Cell ◽

Functional Characterization ◽

Inflammatory Cell Infiltrate ◽

Cell Infiltrate ◽

Autoimmune Enteropathy

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Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells

Journal of Fungi ◽

10.3390/jof7070533 ◽

2021 ◽

Vol 7 (7) ◽

pp. 533

Author(s):

Ailish Williams ◽

Helen Rogers ◽

David Williams ◽

Xiao-Qing Wei ◽

Damian Farnell ◽

...

Keyword(s):

Oral Mucosa ◽

Oral Lichen Planus ◽

Inflammatory Cell ◽

Candida Infection ◽

Inflammatory Cell Infiltrate ◽

T Helper ◽

Cell Infiltrate ◽

High Prevalence ◽

Squamous Cell Papilloma ◽

Oral Lichen

Previous research into the inflammatory cell infiltrate of chronic hyperplastic candidosis (CHC) determined that the immune response is primarily composed of T cells, the majority of which are T helper (CD4+) cells. This present investigation used immunohistochemistry to further delineate the inflammatory cell infiltrate in CHC. Cells profiled were those expressing IL-17A cytokine, EBI3 and IL-12A subunits of the IL-35 cytokine, and FoxP3+ cells. Squamous cell papilloma (with Candida infection) and oral lichen planus tissues served as comparative controls to understand the local immune responses to Candida infection. The results demonstrated that Candida-induced inflammation and immune regulation co-exist in the oral mucosa of CHC and that high prevalence of cells expressing the EBI3 cytokine subunit may play an important role in this regulation. This balance between inflammation and immune tolerance toward invading Candida in the oral mucosa may be critical in determining progress of infection.

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