scholarly journals Relationships of Nerve Conduction Parameters with the Thyroid Hormones in Hypothyroid Patients

2013 ◽  
Vol 8 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Sabina Yeasmin ◽  
Noorzahan Begum ◽  
Shelina Begum ◽  
Shah Mohammed Hafizur Rahman
Keyword(s):  
Thyroid Hormone ◽  
Motor Function ◽  
Nerve Conduction ◽  
Motor Nerve ◽  
Hormone Replacement ◽  
Sensory Function ◽  
Positive Correlation ◽  
Sensory Conduction ◽  
Conduction Velocities ◽  
Hypothyroid Patients

Background: Impairment of nerve conduction may occur in hypothyroidism which usually develops insidiously over a long period of time due to irregular taking of drugs or lack of thyroid hormone replacement. Objectives: To evaluate the thyroid hormone status and the clinical and electrophysiological changes in hypothyroid patients in order to observe their relationships with nerve conduction changes. Methods: Thirty healthy euthyroid subjects with the age range from 20 to 50 years of both sexes were as control and 15 hypothyroids with TSH with <60 MIU /L and the duration of 6 months to 5 years were as experimental. Serum TT3, TT4 were measured by RIA and IRMA method. The distal latency (D L) and Nerve Conduction Velocities (NCV) for sensory and motor function were measured by a standard electrophysiological technique in median and ulnar nerve for upper limb and for lower limb, in sural nerve for sensory function and common peroneal nerve for motor function. Data were analyzed statistically by unpaired ’t’ test, Z test, Pearson’s correlation coefficient test. Results: Both TT3, TT4 levels were significantly (P<0.001) lower in hypothyroids. Again, 60% hypothyroids and 10% euthyroids (P<.001) had abnormal NCV. The relationships of TSH with both the median and ulnar sensory and motor distal latencies, common peroneal motor and sural sensory distal latencies and ulnar sensory conduction velocity were positive. But these relationships were negative with the median and common peroneal motor nerve conduction velocities, sural sensory conduction velocities. Only the relationships between median sensory distal latency and TSH was statistically significant (P <0.05). Again, a positive correlation of TT3 and TT4 with the median, and sural sensory and common peroneal motor conduction velocities, but negative correlation with median motor and sural sensory latencies were found. In addition, positive correlation between TT3 and ulnar sensory and between TT4 and Ulnar motor conduction velocities were observed. Again the relationships median and ulnar sensory latencies were negative with TT4 only. The value of coefficient between TT4 and sural distal latency and conduction velocities were statistically significant (P<0.05). Conclusion: Results of this study showed that the impairment of nerve conduction occurs in hypothyroidism. DOI: http://dx.doi.org/10.3329/jbsp.v8i1.16638 J Bangladesh Soc Physiol. 2013, June; 8(1): 1-5

scholarly journals Correlation of nerve conduction study parameters with thyroid hormone in newly diagnosed hypothyroid patients

2021 ◽  
Vol 12 (11) ◽  
pp. 139-142
Author(s):  
Shital Gupta ◽  
Rita Khadka ◽  
Dilip Thakur ◽  
B. H. Paudel ◽  
Robin Maskey ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Median Nerve ◽  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Sensory Nerve ◽  
Health Science ◽  
Newly Diagnosed ◽  
Positive Correlation ◽  
Entrapment Neuropathies ◽  
Hypothyroid Patients

Background: Thyroid hormones act on many organs including central and peripheral nervous system for maintaining metabolic homeostasis. Entrapment neuropathies are most common in hypothyroidism. Nerve conduction parameters are impaired even in newly diagnosed cases of hypothyroid. Aims and Objectives: This study aims to study the correlation between thyroid hormone and nerve conduction study (NCS) parameters in newly diagnosed hypothyroid patients. Materials and Methods: This cross-sectional, descriptive study included newly diagnosed hypothyroid patients (n=30; age: 31.96±9.12). In all subjects, NCS was performed in median, ulnar, tibial motor nerve and median, ulnar, sural sensory nerve using Nihon Kohden machine in Neurophysiology lab 2, B. P. Koirala Institute of Health Science. Thyroid function test (TFT) was analyzed by ELISA. The association between thyroid hormone and NCS parameters was done using Pearson’s correlation. Results: In NCS sensory parameters; SNAP amplitude of the left sural nerve showed significant positive correlation with t3 (lt; r=0.451, P=0.012). Among motor parameters, distal latency of left median nerve showed significant negative correlation with t3 whereas nerve conduction velocity of the left median nerve showed positive correlation with t3. In rest of the nerve, the association between NCS parameters and TFT (t3, t4, and TSH) parameters did not show any significant changes. Conclusion: Our study reveals that in newly diagnosed cases of hypothyroidism, nerve impairment occurs in which the left side is affected much earlier than right side and further its severity can be correlated with level of T3 rather than TSH.

Linear modulation of serum thyrotrophin by thyroid hormone treatment in hypothyroidism

1980 ◽  
Vol 95 (4) ◽  
pp. 472-478 ◽  
Author(s):  
A. Eugene Pekary ◽  
Jerome M. Hershman ◽  
Clark T. Sawin
Keyword(s):  
Thyroid Hormone ◽  
Hormone Replacement ◽  
Hormone Treatment ◽  
Significant Negative Correlation ◽  
Thyroid Hormone Replacement ◽  
Basal Serum ◽  
Thyroid Hormone Levels ◽  
Peak Versus ◽  
Hypothyroid Patients ◽  
Serum Tsh

Abstract. Basal serum TSH and the peak TSH response to a 500 μg TRH bolus were measured in 57 euthyroid and in 29 hypothyroid subjects either receiving graded thyroid hormone replacement or acutely removed from full replacement therapy. Serum TSH, total T4 and T3 were determined by sensitive radioimmunoassay methods. The peak versus basal TSH data for hypothyroid patients were linear within individuals. The regression slope of the peak versus basal TSH data for all hypothyroid subjects did not differ significantly from the corresponding slope for all euthyroid subjects. Basal and peak TSH versus T3 and T4 data for hypothyroid patients were also linear within each individual. Moreover, the regression of the basal TSH values averaged over the non-replacement to full replacement state against the TSH versus T3 slope had a significant negative correlation. This trend leads to an array of regression lines which average to the familiar hyperbolic relationship between thyrotrophin and thyroid hormone levels in man.

scholarly journals Combination Treatment with T4 and T3: Toward Personalized Replacement Therapy in Hypothyroidism?

2012 ◽  
Vol 97 (7) ◽  
pp. 2256-2271 ◽  
Author(s):  
Bernadette Biondi ◽  
Leonard Wartofsky
Keyword(s):  
Quality Of Life ◽  
Thyroid Hormone ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Hormone Action ◽  
Thyroid Hormone Replacement ◽  
Thyroid Hormone Action ◽  
Thyroid Hormone Replacement Therapy ◽  
Hypothyroid Patients

Abstract Context: Levothyroxine therapy is the traditional lifelong replacement therapy for hypothyroid patients. Over the last several years, new evidence has led clinicians to evaluate the option of combined T3 and T4 treatment to improve the quality of life, cognition, and peripheral parameters of thyroid hormone action in hypothyroidism. The aim of this review is to assess the physiological basis and the results of current studies on this topic. Evidence Acquisition: We searched Medline for reports published with the following search terms: hypothyroidism, levothyroxine, triiodothyronine, thyroid, guidelines, treatment, deiodinases, clinical symptoms, quality of life, cognition, mood, depression, body weight, heart rate, cholesterol, bone markers, SHBG, and patient preference for combined therapy. The search was restricted to reports published in English since 1970, but some reports published before 1970 were also incorporated. We supplemented the search with records from personal files and references of relevant articles and textbooks. Parameters analyzed included the rationale for combination treatment, the type of patients to be selected, the optimal T4/T3 ratio, and the potential benefits of this therapy on symptoms of hypothyroidism, quality of life, mood, cognition, and peripheral parameters of thyroid hormone action. Evidence Synthesis: The outcome of our analysis suggests that it may be time to consider a personalized regimen of thyroid hormone replacement therapy in hypothyroid patients. Conclusions: Further prospective randomized controlled studies are needed to clarify this important issue. Innovative formulations of the thyroid hormones will be required to mimic a more perfect thyroid hormone replacement therapy than is currently available.

Electrophysiological Studies of Nerve Function in Patients on CAPD over Long Periods

1985 ◽  
Vol 5 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Donald Kim ◽  
Gordon Blair ◽  
George Wu ◽  
Anthony Ayiomamitis ◽  
Dimitrios G. Oreopoulos
Keyword(s):  
Nerve Conduction ◽  
Motor Nerve ◽  
Linear Regression Analysis ◽  
Sensory Nerve ◽  
Diabetic Patients ◽  
Nerve Function ◽  
Mean Values ◽  
Conduction Velocities ◽  
Electrophysiological Studies ◽  
Peripheral Nerve Function

The authors studied electrophyhsiological parameters in 29 patients (23 non-diabetics, six diabetics, mean age 47.9, range 16–74 yr.), who had been on CAPD for three to five years. The parameters studied were: motor nerve conduction velocities of the median, ulnar, and peroneal nerves, and sensory nerve conduction velocities of the median and ulnar nerves. These parameters were measured before or within the first month of CAPD and every six months thereafter. The changes in nerve conduction velocities were studied using simple linear regression analysis, and calculating the differences of the slopes from zero. Comparison of the mean values of the conduction velocities in non-diabetics at the beginning of CAPD and in age - matched, non uremic patients showed significantly (p < 0.001) lower values in all parameters measured. The initial nerve conduction velocities in diabetic patients were significantly (p < 0.01) slower than in non-diabetics except sensory conduction velocity of the ulnar nerve. The slopes of nerve conduction velocities plotted against time were not significantly different from zero for any nerve in both non-diabetics and diabetic patients. In conclusion, no significant change in peripheral nerve function was seen after long term CAPD in either diabetic or non-diabetic patients.

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