scholarly journals Reccurent episodes of vomiting and hyperpigmentation---Addison,s disease, a case report

2018 ◽  
Vol 29 (2) ◽  
pp. 66-69
Author(s):  
MB Uddin ◽  
F Zaman ◽  
KI Jahan ◽  
MH Tarafder ◽  
A Hossain ◽  
...  
Keyword(s):  
Case Report ◽  
Adrenal Insufficiency ◽  
Acute Stress ◽  
Addison’S Disease ◽  
High Index ◽  
Recurrent Episode ◽  
Addison's Disease ◽  
Acute Adrenal Insufficiency ◽  
High Index Of Suspicion ◽  
Specific Symptoms

Addison’s disease can remain unrecognized for a longtime until acute adrenal insufficiency is precipitated by an acute stress. Addison’s disease usually presents with non-specific symptoms like fatigue, nausea, vomiting, hyperpigmentation and generalized weakness. These symptoms are most often ignored or misinterpreted with other more common diseases. This is the major reason that this disease is under-diagnosed. Therefore, to establish a diagnosis high index of suspicion is needed.We are reporting a case of 10 years old boy who presented with recurrent episode of severe vomiting and generalized weakness. This kind of presentation of Addison’s disease is rather unusual and mainstay of diagnosis is clinical based.TAJ 2016; 29(2): 66-69

scholarly journals Cyclical hematuria-ureteral endometriosis: a case report

2018 ◽  
Vol 7 (4) ◽  
pp. 1648
Author(s):  
Sindura Ganga Ravula ◽  
Harish Shetty ◽  
Aparna Rajesh
Keyword(s):  
Renal Failure ◽  
Case Report ◽  
Early Diagnosis ◽  
Renal Involvement ◽  
High Index ◽  
True Incidence ◽  
Ureteral Endometriosis ◽  
High Index Of Suspicion ◽  
Specific Symptoms

Little attention has been paid for the renal involvement in endometriosis, a rare and silent disorder which ultimately lead to renal failure. Involvement most commonly may be limited to single ureter (left one) and it is usually involvement extrinsically. Although cases have been reported in the literature, true incidence of ureteral involvement is still not known. The diagnosis is difficult as the disease has non-specific symptoms. Only high index of suspicion with radiological support would be helpful in early diagnosis. Early cases may be benefited with progestin or Anti-aromatase therapy, most cases need surgery, either laparoscopically or laparotomy.

scholarly journals Addison’s disease in antiphospholipid syndrome: a rare complication

2018 ◽  
Vol 2018 ◽  
Author(s):  
Diana Oliveira ◽  
Mara Ventura ◽  
Miguel Melo ◽  
Sandra Paiva ◽  
Francisco Carrilho
Keyword(s):  
Adrenal Insufficiency ◽  
Antiphospholipid Syndrome ◽  
Rare Complication ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
List Type ◽  
Adrenal Imaging ◽  
Significant Clinical Improvement ◽  
Life Threatening ◽  
High Index Of Suspicion

Summary Addison’s disease (AD) is the most common endocrine manifestation of antiphospholipid syndrome (APS), but it remains a very rare complication of the syndrome. It is caused by adrenal venous thrombosis and consequent hemorrhagic infarction or by spontaneous (without thrombosis) adrenal hemorrhage, usually occurring after surgery or anticoagulant therapy. We present a clinical case of a 36-year-old female patient with a previous diagnosis of APS. She presented with multiple thrombotic events, including spontaneous abortions. During evaluation by the third episode of abortion, a CT imaging revealed an adrenal hematoma, but the patient was discharged without further investigation. A few weeks later, she presented in the emergency department with manifestations suggestive of adrenal insufficiency. Based on that assumption, she started therapy with glucocorticoids, with significant clinical improvement. After stabilization, additional investigation confirmed AD and excluded other etiologies; she also started mineralocorticoid replacement. This case illustrates a rare complication of APS that, if misdiagnosed, may be life threatening. A high index of suspicion is necessary for its diagnosis, and prompt treatment is crucial to reduce the morbidity and mortality potentially associated. Learning points: AD is a rare but life-threatening complication of APS. It is important to look for AD in patients with APS and a suggestive clinical scenario. APS must be excluded in patients with primary adrenal insufficiency and adrenal imaging revealing thrombosis/hemorrhage. Glucocorticoid therapy should be promptly initiated when AD is suspected. Mineralocorticoid replacement must be started when there is confirmed aldosterone deficiency. Hypertension is a common feature of APS; in patients with APS and AD, replacement therapy with glucocorticoids and mineralocorticoids may jeopardize hypertension management.

scholarly journals Addison’s disease presenting only with hyperpigmentation – A rare case report

2020 ◽  
Vol 11 (e) ◽  
pp. e161.-e161.3
Author(s):  
Ramin Mofarrah ◽  
Ramina Mofarrah ◽  
Melika Ashoorinezhad
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Adrenocortical Insufficiency ◽  
Rare Case Report ◽  
Long Time ◽  
The Face ◽  
Skin Biopsies ◽  
Specific Symptoms

Addison’s disease or chronic adrenocortical insufficiency, can remain unrecognized for a long time. It usually presents with non-specific symptoms, which are often ignored or misdiagnosed as a sign of other more common diseases. In this case report we focused on subtle findings of diffuse hyperpigmentation. We present a study on 2 skin biopsies from a 38-year-old woman in whom hyperpigmentation lesions were first found on the face and after two months, in the oral cavity. Addison’s disease usually presents with non-specific symptoms and this can be a rare case because it presents with hyperpigmentation as its only sign and has no other clinical symptoms.There are a few diagnosed cases of this disease with hyperpigmentation only.

Case report: Pituitary enlargement associated with Addison's disease

1987 ◽  
Vol 38 (4) ◽  
pp. 435-437 ◽  
Author(s):  
Katsuyoshi Mineura ◽  
Tsuneo Goto ◽  
Motohiro Yoneya ◽  
Masayoshi Kowada ◽  
Yoshihara Tamakawa ◽  
...  
Keyword(s):  
Case Report ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Pituitary Enlargement

scholarly journals Bilateral Charcot hip Arthropathy Due to Tabes Dorsalis: A Case Report

2018 ◽  
Vol 25 (1) ◽  
pp. 21-23
Author(s):  
Ip Hoi Yeung ◽  
Yeung Yip Kan ◽  
Luk Kristine Shik ◽  
Lam Polly Wy ◽  
Wong Kwok Ho
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Clinical Course ◽  
High Index ◽  
Tabes Dorsalis ◽  
High Index Of Suspicion

This article illustrates the clinical course of a patient diagnosed to have bilateral Charcot hip arthropathy secondary to tabes dorsalis from delayed untreated syphilitic infection. This differential diagnosis of rapid bilateral hip destruction was a near-extinct entity, and a high index of suspicion is needed to prevent untoward sequelae.

scholarly journals Addison’s Disease and Dilated Cardiomyopathy: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Viktoriya Mozolevska ◽  
Anna Schwartz ◽  
David Cheung ◽  
Bilal Shaikh ◽  
Kapil M. Bhagirath ◽  
...  
Keyword(s):  
Case Report ◽  
Dilated Cardiomyopathy ◽  
Clinical Presentation ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Review Of The Literature ◽  
Cardiac Disorder ◽  
New Onset

Addison’s disease is often accompanied by a number of cardiovascular manifestations. We report the case of a 30-year-old man who presented with a new onset dilated cardiomyopathy due to Addison’s disease. The clinical presentation, treatment, and outcomes of this rare hormone mediated cardiac disorder are reviewed.

scholarly journals Primary adrenal insufficiency due to bilateral adrenal infarction in COVID-19: a case report

2021 ◽  
Author(s):  
Iza F R Machado ◽  
Isabel Q Menezes ◽  
Sabrina R Figueiredo ◽  
Fernando Morbeck Almeida Coelho ◽  
Debora R B Terrabuio ◽  
...  
Keyword(s):  
Case Report ◽  
Adrenal Insufficiency ◽  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Case Reports ◽  
Serum Cortisol ◽  
Primary Adrenal Insufficiency ◽  
Acute Adrenal Insufficiency ◽  
Adrenal Infarction ◽  
New Onset

Abstract Context Coronavirus disease 2019 (COVID-19) is a proinflammatory and prothrombotic condition, but its impact on adrenal function has not been adequately evaluated. Case report A 46-year-old woman presented with abdominal pain, hypotension, skin hyperpigmentation after COVID-19 infection. The patient had hyponatremia, serum cortisol <1.0 ug/dL, ACTH of 807 pg/mL and aldosterone <3 ng/dL. Computed tomography (CT) findings of adrenal enlargement with no parenchymal and minimal peripheral capsular enhancement after contrast were consistent with bilateral adrenal infarction. The patient had autoimmune hepatitis and positive antiphospholipid antibodies, but no previous thrombotic events. The patient was treated with intravenous hydrocortisone, followed by oral hydrocortisone and fludrocortisone. Discussion Among 115 articles, we identified nine articles, including case reports, of new-onset adrenal insufficiency and/or adrenal hemorrhage/infarction on CT in COVID-19. Adrenal insufficiency was hormonally diagnosed in five cases, but ACTH levels were measured in only three cases (high in one case and normal/low in other two cases). Bilateral adrenal non- or hemorrhagic infarction was identified in five reports (two had adrenal insufficiency, two had normal cortisol levels and one case had no data). Interestingly, the only case with well-characterized new-onset acute primary adrenal insufficiency after COVID-19 had a previous diagnosis of antiphospholipid syndrome. In our case, antiphospholipid syndrome diagnosis was established only after the adrenal infarction triggered by COVID-19. Conclusions Our findings support the association between bilateral adrenal infarction and antiphospholipid syndrome triggered by COVID-19. Therefore, patients with positive antiphospholipid antibodies should be closely monitored for symptoms or signs of acute adrenal insufficiency during COVID-19.

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