scholarly journals Herlyn-Werner-Wunderlich Syndrome with Central Precocious Puberty: A Case Report

2019 ◽  
Vol 23 (2) ◽  
pp. 124-127
Author(s):  
Jeeho Han ◽  
Jae Man Lee ◽  
Geon Hee Kim ◽  
Su Jin Kim
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Central Precocious Puberty

scholarly journals Hypothalamic hamartoma presenting as central precocious puberty: a rare case report

2020 ◽  
Vol 7 (7) ◽  
pp. 1634
Author(s):  
Priyanka Sharma ◽  
Nishant Acharya ◽  
Trilok C. Guleria
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Rare Case ◽  
Treatment Options ◽  
Central Precocious Puberty ◽  
Breast Size ◽  
Hypothalamic Hamartoma ◽  
Gnrh Analog ◽  
Gnrh Analogs ◽  
Rare Case Report

Precocious puberty is defined as children attaining puberty more than 2.5 to 3 standard deviations (SD) earlier than the median age, or before the age of eight years in girls and nine years in boys. Hypothalamic hamartoma (HH) are rare, non progressive tumor like malformation. Precocious puberty due to HH occurs particularly at early ages, even 2 or 3 years. Treatment options for isolated CPP due to HH include GnRH analogs agonists continuously stimulates pituitary gonadotrophs, which further help in decreasing and desensitizing the release of LH, and to a lesser extent, FSH till the time puberty naturally set in. We present a case of precocious puberty due to hypothalamic hamartoma in 3 years old girl. Treated with GnRH analog lupirode and responded well to treatment with cessation of menstruation and reduction in breast size.

scholarly journals A Novel Loss-of-Function MKRN3 Variant in a Chinese Patient With Familial Precocious Puberty: A Case Report and Functional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Xueling Yin ◽  
Junqi Wang ◽  
Tianting Han ◽  
Zhang Tingting ◽  
Yuhong Li ◽  
...  
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Transcriptional Activity ◽  
Central Precocious Puberty ◽  
Chinese Patient ◽  
Functional Study ◽  
Loss Of Function ◽  
Pediatric Endocrinology ◽  
Functional Studies ◽  
Clinical Pediatric

Background: Central precocious puberty (CPP) is one of the most common and complex problems in clinical pediatric endocrinology practice. Mutation of the MKRN3 gene can cause familial CPP.Methods and Results: Here we reported a Chinese patient bearing a novel MKRN3 mutation (c.G277A/p.Gly93Ser) and showing the CPP phenotype. Functional studies found that this mutation of MKRN3 attenuated its autoubiquitination, degradation, and inhibition on the transcriptional activity of GNRH1, KISS1, and TAC3 promoters.Conclusion: MKRN3 (Gly93Ser) is a loss-of-function mutation, which attenuates the inhibition on GnRH1-related signaling, suggesting that this mutant can lead to central precocious puberty.

scholarly journals Dandy-Walker variant with precocious puberty: a rare association

2018 ◽  
Vol 11 (1) ◽  
pp. e226281
Author(s):  
Rajesh Rajput ◽  
Sanat Mishra ◽  
Parul Ahlawat ◽  
Pawan Kumar Yadav
Keyword(s):  
Case Report ◽  
Posterior Fossa ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Secondary Sexual Characteristics ◽  
Rare Association ◽  
Dandy Walker Malformation ◽  
Secondary Hypothyroidism ◽  
Sexual Characteristics ◽  
Walker Malformation

Precocious puberty is characterised by premature appearance of secondary sexual characteristics before the age of 7 years in girls and 9 years in boys. Dandy-Walker malformation comprises a spectrum of intracranial malformations of the posterior fossa. We present a case of a 7-year-old male child who has presented with features of central precocious puberty and on further evaluation has been found to have Dandy-Walker variant and secondary hypothyroidism. The following case report describes this association which is extremely rare and has never been described in literature.

scholarly journals Central Precocious Puberty as a Complication of Congenital Adrenal Hyperplasia in a Boy: Case Report

2021 ◽  
Vol 44 (3) ◽  
pp. 184-187
Author(s):  
Farzana Sharmin ◽  
Suraiya Begum ◽  
Ismat Jahan ◽  
Tawhid Alam ◽  
Dhiraj Chandra Biswas
Keyword(s):  
Case Report ◽  
Child Health ◽  
Congenital Adrenal Hyperplasia ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Well Being ◽  
Adrenal Hyperplasia ◽  
Peripheral Precocious Puberty

Precocious puberty has intense influence on physical and psychosocial well-being of affected children and raises a lot of concerns as well as uncertainties in family.Here,we report a case of Central precocious puberty (CPP)superimposed on peripheral precocious puberty (PPP) due to congenital adrenal hyperplasia(CAH). Bangladesh J Child Health 2020; VOL 44 (3) :184-187

CENTRAL PRECOCIOUS PUBERTY IN MULTISYSTEM LANGERHANS CELL HISTIOCYTOSIS: A Case Report

2002 ◽  
Vol 19 (4) ◽  
pp. 273-278 ◽  
Author(s):  
G. Municchi ◽  
S. Marconcini ◽  
A. D'Ambrosio ◽  
R. Berardi ◽  
A. Acquaviva
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Langerhans Cell Histiocytosis ◽  
Central Precocious Puberty ◽  
Langerhans Cell

scholarly journals Precocious Puberty- A Case Report

1970 ◽  
Vol 21 (1) ◽  
pp. 83-86
Author(s):  
K Kabiruzzaman Shah ◽  
N Begum Laz ◽  
AB Siddique ◽  
FU Ahmed
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Sexual Development ◽  
Central Precocious Puberty ◽  
Female Child ◽  
Male Child ◽  
Sex Steroid ◽  
Steroid Secretion ◽  
Gonadotrophin Secretion ◽  
Hypothalamic Pituitary Axis

Appearance of secondary sexual development before the age of 9 in a male child and before the age of 7 in a female child is called precocious puberty. When the cause of precocious puberty is premature activation of the hypothalamic-pituitary axis, it is called central or complete precocious puberty, if ectopic gonadotrophin secretion occurs in boys or autonomous sex steroid secretion occurs in either sex it is called incomplete precocious puberty. |Here we are reporting a 5 year old girl with central precocious puberty.   doi: 10.3329/taj.v21i1.3227 TAJ 2008; 21(1): 83-86

scholarly journals MB-27A CASE REPORT OF CENTRAL PRECOCIOUS PUBERTY IN A 7 YEARS OLD MALE WITH MEDULLOBLASTOMA PRESENTING WITH HYDROCEPHALUS

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii102.4-iii102
Author(s):  
Suzanne Conley ◽  
Pournima Navalkele ◽  
Diana S. Osorio ◽  
Eric Sribnick ◽  
Daniel R. Boue' ◽  
...  
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Central Precocious Puberty
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