scholarly journals Precocious Puberty- A Case Report

1970 ◽  
Vol 21 (1) ◽  
pp. 83-86
Author(s):  
K Kabiruzzaman Shah ◽  
N Begum Laz ◽  
AB Siddique ◽  
FU Ahmed
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Sexual Development ◽  
Central Precocious Puberty ◽  
Female Child ◽  
Male Child ◽  
Sex Steroid ◽  
Steroid Secretion ◽  
Gonadotrophin Secretion ◽  
Hypothalamic Pituitary Axis

Appearance of secondary sexual development before the age of 9 in a male child and before the age of 7 in a female child is called precocious puberty. When the cause of precocious puberty is premature activation of the hypothalamic-pituitary axis, it is called central or complete precocious puberty, if ectopic gonadotrophin secretion occurs in boys or autonomous sex steroid secretion occurs in either sex it is called incomplete precocious puberty. |Here we are reporting a 5 year old girl with central precocious puberty.   doi: 10.3329/taj.v21i1.3227 TAJ 2008; 21(1): 83-86

scholarly journals Precocious Puberty – A Case Report

2016 ◽  
Vol 30 (2) ◽  
pp. 109-112
Author(s):  
Poly Begum ◽  
Dipti Rani Saha ◽  
Md Kamrul Hassan
Keyword(s):  
Precocious Puberty ◽  
Pubertal Development ◽  
Tanner Stage ◽  
Central Precocious Puberty ◽  
Female Child ◽  
Pubic Hair ◽  
Breast Development ◽  
Average Height ◽  
Hypothalamic Pituitary Axis ◽  
Hair Development

The parents of a 04-year-old girl bring her to a Gynaecologist because of breast development, appearance of pubic hair and periodic per vaginal bleeding. Her medical history is unremarkable. The parents are of average height, and the mother reports first menstruating when she was 11 years old. At physical examination, the girl is 100 cm tall , weighs 17 kg, and has a bodymass index of 17. Her pubertal development is classified as Tanner stage 3 breast development and Tanner stage 2 pubic hair development. She was diagnosed as a case of precocious puberity. Appearance of secondary sexual development before the age of 9 in a male child and before the age of 8 in a female child is called precocious puberty. When the cause of precocious puberty is premature activation of the hypothalamic-pituitary axis, it is called central or complete precocious puberty and she was a case of central precocious puberty. After proper consult she was treated by GnRHa suppressor of pituitary till 11 years of age.Bangladesh J Obstet Gynaecol, 2015; Vol. 30(2) : 109-112

scholarly journals A 4-Year-Old Girl with Precocious Puberty

2016 ◽  
Vol 6 (3) ◽  
pp. 161-163
Author(s):  
Poly Begum ◽  
Dipti Rani Saha ◽  
Md Kamrul Hassan
Keyword(s):  
Precocious Puberty ◽  
Vaginal Bleeding ◽  
Pubertal Development ◽  
Tanner Stage ◽  
Female Child ◽  
Pubic Hair ◽  
Breast Development ◽  
Average Height ◽  
Gonadotrophin Secretion ◽  
Hypothalamic Pituitary Axis

Appearance of secondary sexual development before the age of nine in a male child and before the age of eight in a female child is called precocious puberty. Precocious puberty due to premature activation of the hypothalamic-pituitary axis is called central or complete precocious puberty. Incomplete precocious puberty is called if ectopic gonadotrophin secretion occurs in boys or autonomous sex steroid secretion occurs in either sex. Here we report a case of a 4-year-old girl brought to a gynecologist by her parents because of breast development, pubic hair and periodic per vaginal bleeding. Her medical history was unremarkable. The parents were of average height, and the mother reported first menstruation when she was 11 years. At physical examination, the girl was 100 cm tall, weighed 17 kg, and had a body mass index of 17. Her pubertal development is classified as Tanner stage 3 breast development and Tanner stage 2 pubic hair development.J Enam Med Col 2016; 6(3): 161-163

scholarly journals Gonadotropin and Sex Steroid Levels during Long Term Depot Leuprolide Therapy for Central Precocious Puberty

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 95A-95A
Author(s):  
E Kirk Neely ◽  
Raymond L Hintz ◽  
Peter A Lee
Keyword(s):  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Sex Steroid

Growth Patterns and Skeletal Maturation During Sex Steroid Suppression and Reactivation in Central Precocious Puberty

1990 ◽  
pp. 61-74
Author(s):  
Paul A. Boepple ◽  
M. Joan Mansfield ◽  
John D. Crawford ◽  
John F. Crigler ◽  
Kathleen Link ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Growth Patterns ◽  
Skeletal Maturation ◽  
Sex Steroid

scholarly journals Hypothalamic hamartoma presenting as central precocious puberty: a rare case report

2020 ◽  
Vol 7 (7) ◽  
pp. 1634
Author(s):  
Priyanka Sharma ◽  
Nishant Acharya ◽  
Trilok C. Guleria
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Rare Case ◽  
Treatment Options ◽  
Central Precocious Puberty ◽  
Breast Size ◽  
Hypothalamic Hamartoma ◽  
Gnrh Analog ◽  
Gnrh Analogs ◽  
Rare Case Report

Precocious puberty is defined as children attaining puberty more than 2.5 to 3 standard deviations (SD) earlier than the median age, or before the age of eight years in girls and nine years in boys. Hypothalamic hamartoma (HH) are rare, non progressive tumor like malformation. Precocious puberty due to HH occurs particularly at early ages, even 2 or 3 years. Treatment options for isolated CPP due to HH include GnRH analogs agonists continuously stimulates pituitary gonadotrophs, which further help in decreasing and desensitizing the release of LH, and to a lesser extent, FSH till the time puberty naturally set in. We present a case of precocious puberty due to hypothalamic hamartoma in 3 years old girl. Treated with GnRH analog lupirode and responded well to treatment with cessation of menstruation and reduction in breast size.

scholarly journals A Novel Loss-of-Function MKRN3 Variant in a Chinese Patient With Familial Precocious Puberty: A Case Report and Functional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Xueling Yin ◽  
Junqi Wang ◽  
Tianting Han ◽  
Zhang Tingting ◽  
Yuhong Li ◽  
...  
Keyword(s):  
Case Report ◽  
Precocious Puberty ◽  
Transcriptional Activity ◽  
Central Precocious Puberty ◽  
Chinese Patient ◽  
Functional Study ◽  
Loss Of Function ◽  
Pediatric Endocrinology ◽  
Functional Studies ◽  
Clinical Pediatric

Background: Central precocious puberty (CPP) is one of the most common and complex problems in clinical pediatric endocrinology practice. Mutation of the MKRN3 gene can cause familial CPP.Methods and Results: Here we reported a Chinese patient bearing a novel MKRN3 mutation (c.G277A/p.Gly93Ser) and showing the CPP phenotype. Functional studies found that this mutation of MKRN3 attenuated its autoubiquitination, degradation, and inhibition on the transcriptional activity of GNRH1, KISS1, and TAC3 promoters.Conclusion: MKRN3 (Gly93Ser) is a loss-of-function mutation, which attenuates the inhibition on GnRH1-related signaling, suggesting that this mutant can lead to central precocious puberty.

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