scholarly journals Clinical Implications of the Mitotic Index as a Predictive Factor for Malignant Transformation of Atypical Meningiomas

2021 ◽  
Author(s):  
Sae Min Kwon ◽  
Jeong Hoon Kim ◽  
Young-Hoon Kim ◽  
Seok Ho Hong ◽  
Young Hyun Cho ◽  
...  
Keyword(s):  
Mitotic Index ◽  
Malignant Transformation ◽  
Predictive Factor ◽  
Clinical Implications ◽  
Atypical Meningiomas

scholarly journals SURG-29. CLINICAL FACTORS ASSOCIATED WITH RECURRENCE IN ATYPICAL MENINGIOMA: RETROSPECTIVE ANALYSIS OF 99 PATIENTS IN TWO INSTITUTES

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii209-ii209
Author(s):  
Kyung Soo Sung ◽  
Young Jin Song ◽  
Young Zoon Kim
Keyword(s):  
Mitotic Index ◽  
Malignant Transformation ◽  
Surgical Resection ◽  
Tumor Size ◽  
Extent Of Resection ◽  
Atypical Meningioma ◽  
Proliferative Index ◽  
Who Grade ◽  
The Mean ◽  
Atypical Meningiomas

Abstract OBJECTIVE The objectives of this study were to examine the local control (LC) rate of atypical meningioma after surgical resection with or without adjuvant treatment, to identify risk factors for the recurrence of atypical meningioma, and to compare our results to known factors from the literature. METHODS Clinical and radiological records of patients with atypical meningiomas diagnosed at two institutes from January 2000 to December 2018 were reviewed retrospectively. Histopathological features were also reviewed using formalin-fixed paraffin embedded samples from pathological archives. RESULTS Of the 99 atypical meningiomas eligible for analysis, 36 (36.4%) recurred during the follow-up period (mean 83.3 months, range 12–232 months). The rate of 3-year LC and 5-year LC was 80.8% and 74.7% respectively. The mean time-to-recurrence was 49.4 months (range 12–150 months). Multivariate analysis using Cox proportional-hazard regression model showed that the extent of resection (Hazard ratio [HR] 4.761, p=0.013), Ki67 index (HR 8.541, p=0.004), mitotic index (HR 3.275, p=0.044), tumor size (HR 3.228, p=0.041), and radiotherapy (HR 3.816, p=0.029) were independently associated with 3-year LC. These factors was also statistically associated with recurrence-free survival. In terms of radiotherapy after surgical resection, the recurrence was not prevented by immediate radiotherapy because of the strong effect of proliferative index on recurrence. Three cases of malignant transformation to WHO grade III meningioma were histopathologically confirmed after repeated surgery. Two out of these three patients succumbed to malignant transformation. The mean Ki67 proliferative index increased for recurrent cases in 18 patients (58.1%) from 7.55% (range 4-16) to 11.81% (range 5-24). CONCLUSION The present study suggests that the extent of resection, proliferative index (according to Ki67 expression) and mitotic index, tumor size, and radiotherapy are associated with recurrence of atypical meningiomas. However, our results should be further validated through prospective and randomized clinical trials.

scholarly journals CTNI-55. PREDICTIVE FACTORS FOR HIGH GRADE TRANSFORMATION IN BENIGN MENINGIOMAS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii55-ii55
Author(s):  
Jeong Hoon Kim ◽  
Hee Jun Yoo
Keyword(s):  
Mitotic Index ◽  
Atypical Meningioma ◽  
Benign Tumors ◽  
Time Interval ◽  
High Grade ◽  
Peritumoral Edema ◽  
Benign Meningioma ◽  
Who Grade ◽  
High Grade Transformation ◽  
Atypical Meningiomas

Abstract OBJECT Meningiomas are generally slow-growing, benign tumors, most of which are classified as WHO Grade I. Rarely, benign meningiomas may recur after surgery with transformation into WHO Grade II atypical meningiomas. As atypical meningiomas are different from benign meningiomas in terms of clinical course, and prognosis, predicting the transformation is important for patient management. The purpose of the study was to investigate the radiological and pathological factors that predict the risk of tumor progression from benign to atypical meningioma. METHOD All patients treated with recurrent meningiomas in whom the tumor showed histopathologically confirmed high grade transformation between 2001 and 2017 were included. To evaluate the predictors for transformation, patients’ medical records for previous benign meningioma before transformation were collected. Each patient was matched with 4 age and sex-matched controls treated with benign meningioma, and were analyzed. RESULTS Fourteen patients with high grade transformation were included. The median time interval of transformation was 63 months (range of 19 – 132). Multivariate analysis indicated that increased mitotic index (OR, 10.409, 95% CI, 1.297–83.549, p=0.027) was significant predictive factor of transformation. And prominent peritumoral edema (OR, 33.822, 95% CI, 0.935–223.688, p=0.054) showed relative risk for transformation. CONCLUSION Increased mitotic index and prominent peritumoral edema may be predictors for high grade transformation of benign meningiomas. Although these tumors do not meet the criteria for atypical meningioma, they may be required more attentive observation and management than other benign meningiomas.

Mitotic Index and Progression-Free Survival in Atypical Meningiomas

2020 ◽  
Vol 142 ◽  
pp. 191-196 ◽  
Author(s):  
Ricardo A. Domingo ◽  
Shashwat Tripathi ◽  
Tito Vivas-Buitrago ◽  
Victor M. Lu ◽  
Kaisorn L. Chaichana ◽  
...  
Keyword(s):  
Mitotic Index ◽  
Progression Free Survival ◽  
Free Survival ◽  
Atypical Meningiomas

Tumor angiogenesis as predictive factor for site of relapse in patients with gastric cancer: Biological and clinical implications.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. e21119-e21119
Author(s):  
R. Giampieri ◽  
M. Scartozzi ◽  
C. Loretelli ◽  
E. Galizia ◽  
M. Pistelli ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Angiogenesis ◽  
Predictive Factor ◽  
Clinical Implications

Mitotic Index Is the Best Predictive Factor for Survival of Patients with Resected Hepatocellular Carcinoma

2000 ◽  
Vol 17 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Kiyoaki Ouchi ◽  
Tohoru Sugawara ◽  
Hidemaro Ono ◽  
Tsuneaki Fujiya ◽  
Yasuhiko Kamiyama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mitotic Index ◽  
Predictive Factor

scholarly journals Mechanistic and clinical insights at the scleroderma-cancer interface

2017 ◽  
Vol 2 (3) ◽  
pp. 153-159 ◽  
Author(s):  
Ami A. Shah ◽  
Livia Casciola-Rosen
Keyword(s):  
Chronic Inflammation ◽  
Malignant Transformation ◽  
Clinical Implications ◽  
Increased Risk ◽  
Risk Of Cancer

Emerging data suggest tantalizing links between cancer and systemic inflammatory rheumatic syndromes. In scleroderma, patients may have an increased risk of cancer, secondary to chronic inflammation and damage from the disease, malignant transformation promoted by immunosuppressive therapies, a shared susceptibility to both cancer and autoimmunity, or a common inciting exposure. However, it is increasingly recognized that a subset of patients develop cancer around the time that scleroderma clinically manifests, raising the question of cancer-induced autoimmunity. In this review, we discuss data suggesting a mechanistic link between cancer and the development of scleroderma, and the clinical implications of these findings.

Application of Transmission Electron Microscope and Scanning Electron Microscope in experimental tumor studies

1990 ◽  
Vol 48 (3) ◽  
pp. 306-307
Author(s):  
Gao Fengming
Keyword(s):  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Malignant Transformation ◽  
Transmission Electron Microscope ◽  
Experimental Tumor ◽  
Transmission Electron ◽  
Embryo Cells ◽  
Tumor Studies ◽  
Scanning Electron

Transmission electron microscope(TEM) and scanning electron microscope(SEM) were widely used in experimental tumor studies. They are useful for evaluation of cellular transformation in vitro, classification of histological types of tumors and treating effect of tumors. We have obtained some results as follows:1. Studies on the malignant transformation of mammalian cells in vitro. Syrian golden hamster embryo cells(SGHEC) were transformed in vitro by ThO2 and/or ore dust. In a few days after dust added into medium, some dust crystals were phagocytized. Two weeks later, malignant transformation took place. These cells were of different size, nuclear pleomorphism, numerous ribosomes, increasing of microvilli on cell surface with various length and thickness, and blebs and ruffles(Figs. 1,2). Myelomonocytic leukemic transformation of mouse embryo cells(MEC) was induced in vitro by 3H-TdR. Transformed cells were become round from fusiform. The number of mitochondria and endoplasmic reticulum was reduced, ribosomes and nucleoli increased, shape of nuclei irregular, microvilli increased, and blebs and ruffles appeared(Fig. 3).

Effects of Selected Rhinologic Disorders on the Perception of Nasal Resonance in Children

1984 ◽  
Vol 15 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Michael P. Rastatter ◽  
Melvin Hyman
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Implications ◽  
Normal Children ◽  
Nasal Resonance

A group of sophisticated listeners judged the nasal resonance characteristics of normal children versus children evidencing selected rhinologic disorders under three speaking conditions. Results showed that perceptions of denasality are influenced by both speakers and speaking tasks. That is, children with allergic rhinitis and edemic adenoids were perceived as being denasal when they produced VCV utterances and recited sentences. However, their resonance characteristics were deemed normal for vowel productions. Interestingly, children with severely deviated septums were judged to have normal nasal resonance under all speaking conditions. Clinical implications are discussed.

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