scholarly journals Serum cystatin C level is a useful marker for the evaluation of renal function in patients with cirrhotic ascites and normal serum creatinine levels

2011 ◽  
Vol 17 (2) ◽  
pp. 130 ◽  
Author(s):  
Dong Jin Kim ◽  
Hyun Seok Kang ◽  
Hyuk Soon Choi ◽  
Hye Jin Cho ◽  
Eun Sun Kim ◽  
...  
2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Mohammad Mahdi Sagheb ◽  
Soha Namazi ◽  
Bita Geramizadeh ◽  
Amin Karimzadeh ◽  
Mohammad Bagher Oghazian ◽  
...  

2009 ◽  
Vol 29 (10) ◽  
pp. 1521-1527 ◽  
Author(s):  
Yeon Seok Seo ◽  
Eun Suk Jung ◽  
Hyonggin An ◽  
Jeong Han Kim ◽  
Young Kul Jung ◽  
...  

2008 ◽  
Vol 31 (10) ◽  
pp. 1895-1902 ◽  
Author(s):  
Sang Heon Song ◽  
Ihm Soo Kwak ◽  
Young Joo Kim ◽  
Hee Sun Lee ◽  
Harin Rhee ◽  
...  

Author(s):  
George T John ◽  
Jude Joseph Fleming ◽  
Girish S Talaulikar ◽  
R Selvakumar ◽  
Paaulose P Thomas ◽  
...  

Background: The usefulness of serum cystatin C and serum β2-microglobulin (B2M) as markers of glomerular filtration rate (GFR) were compared in kidney donors before and after nephrectomy. Methods: Blood samples were taken from 28 donors (15 women and 13 men) for serum creatinine, urea, cystatin C and B2M estimation a median of 7 days before and 10 days after nephrectomy. Results: Estimated GFR decreased from a median of 86.2 mL/min/1.73 m2 to 60.3 mL/min/1.73 m2, a median decrease of 28.6%. Serum creatinine increased by 40% and urea by 30.4%; serum cystatin C increased by 31.2% and serum B2M increased by 65.6%. Using published data on biological variation, critical values were calculated. An increase in serum creatinine above 18 µmol/L detected the decline in renal function in 26/28 (92.9%) subjects. Increases in serum B2M greater than a critical value of 0.94 mg/L detected 24/28 (85.7%) of these subjects, but the critical value of 0.59 mg/L for cystatin C detected only 8/28 (28.6%). Conclusion: Using critical values, serial measurement of serum creatinine was better than serum B2M in detecting reduced renal function. Because of its large intraindividual variation, serial serum cystatin C estimation was very poor in detecting reduced renal function.


2008 ◽  
Vol 24 (4) ◽  
pp. 1157-1161 ◽  
Author(s):  
S. Song ◽  
M. Meyer ◽  
T. R. Turk ◽  
B. Wilde ◽  
T. Feldkamp ◽  
...  

1999 ◽  
Vol 10 (1) ◽  
pp. 164-166 ◽  
Author(s):  
ANDREW G. BOSTOM ◽  
REGINALD Y. GOHH ◽  
LINDA BAUSSERMAN ◽  
DAVID HAKAS ◽  
PAUL F. JACQUES ◽  
...  

Abstract. Serum creatinine, a surrogate for both renal function and homocysteine generation, is an important determinant of fasting plasma total homocysteine levels in stable renal transplant recipients. In this study, it is hypothesized that among stable renal transplant recipients with normal creatinine levels (i.e., ≤ 1.5 mg/dl), serum cystatin C, a more sensitive indicator of GFR, would better predict fasting total homocysteine levels compared with serum creatinine. Fasting plasma total homocysteine, folate, vitamin B12, and pyridoxal 5′-phosphate levels, along with serum cystatin C, creatinine, and albumin levels, were determined in 28 consecutive renal transplant recipients (mean age 47 ± 14 yr; 60.7% men) with stable allograft function, whose serum creatinine was ≤1.5 mg/dl. General linear modeling with analysis of covariance revealed that serum cystatin C was independently predictive (partial R = 0.494; P = 0.023) of fasting total homocysteine levels after adjustment for age, gender, vitamin status, albumin, and creatinine levels. In contrast, creatinine levels were not predictive of fasting total homocysteine levels in this model (P = 0.110) or an identical model that excluded cystatin C (P = 0.131). Serum cystatin C levels may reflect subtle decreases in renal function that independently predict fasting total homocysteine levels among stable renal transplant recipients with a normal serum creatinine.


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