scholarly journals Prevention of vertical transmission of the bacterial kidney disease agent Renibacterium salmoninarum by broodstock injection with erythromycin

1994 ◽  
Vol 18 ◽  
pp. 1-4 ◽  
Author(s):  
H Lee EG ◽  
TPT Evelyn
Keyword(s):  
Kidney Disease ◽  
Vertical Transmission ◽  
Renibacterium Salmoninarum ◽  
Bacterial Kidney Disease ◽  
Disease Agent

Evaluation and development of diagnostic methods for Renibacterium salmoninarum causing bacterial kidney disease (BKD) in the UK

Aquaculture ◽  
2007 ◽  
Vol 269 (1-4) ◽  
pp. 114-122 ◽  
Author(s):  
David Bruno ◽  
Bertrand Collet ◽  
Anna Turnbull ◽  
Rachel Kilburn ◽  
Amanda Walker ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Diagnostic Methods ◽  
Renibacterium Salmoninarum ◽  
Bacterial Kidney Disease ◽  
The Uk

scholarly journals Both msa Genes in Renibacterium salmoninarum Are Needed for Full Virulence in Bacterial Kidney Disease

2006 ◽  
Vol 72 (4) ◽  
pp. 2672-2678 ◽  
Author(s):  
Alison M. Coady ◽  
Anthony L. Murray ◽  
Diane G. Elliott ◽  
Linda D. Rhodes
Keyword(s):  
Kidney Disease ◽  
Chinook Salmon ◽  
Oncorhynchus Tshawytscha ◽  
Soluble Antigen ◽  
Renibacterium Salmoninarum ◽  
Juvenile Chinook Salmon ◽  
Bacterial Kidney Disease ◽  
Important Virulence Factor ◽  
Chromosomal Loci

ABSTRACT Renibacterium salmoninarum, a gram-positive diplococcobacillus that causes bacterial kidney disease among salmon and trout, has two chromosomal loci encoding the major soluble antigen (msa) gene. Because the MSA protein is widely suspected to be an important virulence factor, we used insertion-duplication mutagenesis to generate disruptions of either the msa1 or msa2 gene. Surprisingly, expression of MSA protein in broth cultures appeared unaffected. However, the virulence of either mutant in juvenile chinook salmon (Oncorhynchus tshawytscha) by intraperitoneal challenge was severely attenuated, suggesting that disruption of the msa1 or msa2 gene affected in vivo expression.

Genetic effects of ELISA-based segregation for control of bacterial kidney disease in Chinook salmon (Oncorhynchus tshawytscha)

2006 ◽  
Vol 63 (12) ◽  
pp. 2793-2808 ◽  
Author(s):  
Jeffrey J Hard ◽  
Diane G Elliott ◽  
Ronald J Pascho ◽  
Dorothy M Chase ◽  
Linda K Park ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Chinook Salmon ◽  
Oncorhynchus Tshawytscha ◽  
Enzyme Linked Immunosorbent Assay ◽  
Antigen Level ◽  
Renibacterium Salmoninarum ◽  
Listonella Anguillarum ◽  
Bacterial Kidney Disease ◽  
Genetic And Phenotypic Correlations ◽  
High Heritability

We evaluated genetic variation in ability of Chinook salmon (Oncorhynchus tshawytscha) to resist two bacterial pathogens: Renibacterium salmoninarum, the agent of bacterial kidney disease (BKD), and Listonella anguillarum, an agent of vibriosis. After measuring R. salmoninarum antigen in 499 adults by enzyme-linked immunosorbent assay (ELISA), we mated each of 12 males with high or low antigen levels to two females with low to moderate levels and exposed subsets of their progeny to each pathogen separately. We found no correlation between R. salmoninarum antigen level in parents and survival of their progeny following pathogen exposure. We estimated high heritability for resistance to R. salmoninarum (survival h2 = 0.890 ± 0.256 (mean ± standard error)) independent of parental antigen level, but low heritability for resistance to L. anguillarum (h2 = 0.128 ± 0.078). The genetic correlation between these survivals (rA = –0.204 ± 0.309) was near zero. The genetic and phenotypic correlations between survival and antigen levels among surviving progeny exposed to R. salmoninarum were both negative (rA = –0.716 ± 0.140; rP = –0.378 ± 0.041), indicating that variation in antigen level is linked to survival. These results suggest that selective culling of female broodstock with high antigen titers, which is effective in controlling BKD in salmon hatcheries, will not affect resistance of their progeny.

scholarly journals Efficacy of Erymicin 200 Injections for Reducing Renibacterium salmoninarum and Controlling Vertical Transmission in an Inland Rainbow Trout Brood Stock

Pathogens ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 547
Author(s):  
Eric R. Fetherman ◽  
Brad Neuschwanger ◽  
Tracy Davis ◽  
Colby L. Wells ◽  
April Kraft
Keyword(s):  
Rainbow Trout ◽  
Vertical Transmission ◽  
Brood Stock ◽  
Renibacterium Salmoninarum ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Bacterial Kidney Disease ◽  
Treated Fish ◽  
And Control ◽  
Brood Fish ◽  
Significant Mortality

Bacterial Kidney Disease, caused by Renibacterium salmoninarum (Rs), is widespread and can cause significant mortality at most life stages in infected salmonids. Rs is commonly found in inland trout, which can be carriers of the bacterium. Lethal spawns can be used to control vertical transmission to progeny through the culling of eggs from infected parents, but can be costly, time-consuming, and can negatively impact important and rare brood stocks. Erymicin 200 is an Investigational New Animal Drug (INAD) intended to reduce Rs levels in hatchery brood stocks and control vertical transmission to progeny. We tested the efficacy of Erymicin 200 injections in a positive, hatchery-resident rainbow trout (Oncorhynchus mykiss) brood stock in Colorado, USA. Brood fish age two and three were injected with 25 mg per kg of body weight Erymicin 200 three times prior to spawning. Erymicin 200 was effective in reducing Rs to below detectable levels in treated fish. However, both negative treated and control brood fish produced positive progeny, suggesting that Erymicin 200 did not prevent the vertical transmission of Rs.

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