scholarly journals Diagnostic utility of CK20, p53 and KI67 to differentiate between Papillomas/Non-Invasive papillary urothelial Neoplasm of low malignant potential/non-invasive papillary urothelial carcinoma, low grade

2019 ◽  
Vol 2 (1) ◽  
pp. 86-91
Author(s):  
Dr. Dipti Gajjar ◽  
Dr. Mansi Faujdar ◽  
Dr. Rohit Jain ◽  
Dr. Shubha Gupta
Keyword(s):  
Urothelial Carcinoma ◽  
Malignant Potential ◽  
Low Grade ◽  
Diagnostic Utility ◽  
Non Invasive ◽  
Low Malignant Potential ◽  
Papillary Urothelial Carcinoma ◽  
Urothelial Neoplasm

scholarly journals Non-invasive papillary urothelial carcinoma, low-grade of the renal pelvis mimicking a xanthogranulomatous pyelonephritis in a male patient: A case report and review of literature

2020 ◽  
Vol 34 ◽  
pp. 205873842092572
Author(s):  
Xi Xie ◽  
Ning Wang ◽  
Yuyong Wang ◽  
Huadong He ◽  
Fanlei Kong ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Back Pain ◽  
Urothelial Carcinoma ◽  
Male Patient ◽  
Renal Pelvis ◽  
Xanthogranulomatous Pyelonephritis ◽  
Low Grade ◽  
Histopathologic Examination ◽  
Non Invasive ◽  
Papillary Urothelial Carcinoma

We report on a 31-year-old male patient with non-invasive papillary urothelial carcinoma, low grade of the renal pelvis disguised as xanthogranulomatous pyelonephritis. The only symptom of the patient was lower back pain. The initial renal-enhanced computed tomography, magnetic resonance imaging and contrast-enhanced ultrasonography showed that the right kidney had a benign lesion and this inflammatory lesion might be xanthogranulomatous pyelonephritis. A percutaneous renal biopsy was performed and histopathologic examination revealed a xanthogranulomatous pyelonephritis. Initially, we diagnosed it as xanthogranulomatous pyelonephritis and treated it with antibiotics. One and a half years later, the patient suffered from back pain again. The lesion increased significantly and a right renal pelvic lesion with retroperitoneal lymphadenopathy was considered a malignant lesion on computed tomography scan. Therefore, radical resection of right renal pelvis carcinoma was performed under retroperitoneal laparoscopy. Intraoperative frozen section was reported as right renal urothelial carcinoma with no metastasis in renal hilar lymph node. Postoperative histopathologic examination revealed non-invasive papillary urothelial carcinoma, low grade of renal pelvis.

Utility of GATA-3 and Cytokeratin 5/6 Immunostains in Separating Condyloma Acuminatum Arising in the Urinary Tract From Non-Invasive Papillary Urothelial Carcinoma

2021 ◽  
pp. 106689692110522
Author(s):  
Diego Montoya-Cerrillo ◽  
Laurence M. Briski ◽  
Merce Jorda ◽  
Oleksandr N. Kryvenko
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Condylomata Acuminata ◽  
Condyloma Acuminatum ◽  
Low Risk ◽  
Low Grade ◽  
High Grade ◽  
Non Invasive ◽  
Urothelial Carcinomas ◽  
Papillary Urothelial Carcinoma

Background Condyloma acuminatum is a squamous epithelial lesion which uncommonly involves the urinary tract. In this location, non-invasive papillary urothelial carcinoma constitutes one of the main differential diagnoses with significant prognostic and therapeutic implications. To date, no ancillary immunohistochemical stain has been described to differentiate these two entities. We assess the utility of cytokeratin 5/6 (CK5/6) and GATA-3 immunohistochemistry in distinguishing condyloma acuminatum from non-invasive papillary urothelial carcinoma. Design We reviewed 9 condylomata acuminata involving the urinary tract, 12 low-grade and 8 high-grade non-invasive papillary urothelial carcinomas. CK5/6 immunostaining was performed in all cases. GATA-3 immunostaining and low-risk human papilloma virus (HPV) chromogenic in situ hybridization was performed in all condyloma cases and 2 urothelial carcinomas with squamous differentiation. Results 8/9 condylomata acuminata were positive for low-risk HPV. All condylomata acuminata exhibited strong full-thickness cytoplasmic staining for CK5/6. In 10 of 12 low-grade non-invasive papillary urothelial carcinomas, CK5/6 expression was continuous and limited to the basal cell layer, while it was patchy and limited to the basal cell layer in all 8 high-grade non-invasive papillary urothelial carcinomas. Two low-grade non-invasive papillary urothelial carcinomas showed focal full-thickness CK5/6 expression in the areas of squamous differentiation. These 2 cases were negative for low-risk HPV. GATA-3 immunostaining was positive in all condylomata acuminata. Conclusions CK5/6 immunostaining is a useful and simple tool that can help separate low-grade and high-grade non-invasive papillary urothelial carcinomas from condyloma acuminatum involving the urothelium-lined organs. GATA-3 has no discriminatory role between condyloma acuminatum and papillary urothelial carcinomas.

scholarly journals Low Grade Papillary Urothelial Carcinoma

2018 ◽  
Vol 1 (1) ◽  
pp. 119-123
Author(s):  
Dedy Suryadi ◽  
Lidya Imelda Laksmi ◽  
Jessy Chrestella
Keyword(s):  
Urothelial Carcinoma ◽  
Bladder Neoplasms ◽  
Invasive Disease ◽  
Transitional Epithelium ◽  
Low Grade ◽  
Female Ratio ◽  
Non Invasive ◽  
Papillary Urothelial Carcinoma ◽  
Primary Bladder ◽  
Branched Structure

Tumor non-invasif merupakan mayoritas neoplasma kandung kemih primer pada diagnosis awal. Sekitar 70-75% karsinoma urotelial baru adalah non-invasif dan papiler dengan rasio laki-laki-perempuan adalah 3:1. Lebih dari 50% dari tumor ini adalah low grade. Kami melaporkan kasus perempuan 53 tahun yang mengeluh nyeri pinggang tanpa hematuria. Biopsi jaringan dari kandung kemih dilakukan. Pemeriksaan makroskopik dengan volume 1 cc massa putih keabuan dengan permukaan tidak rata. pemeriksaan mikroskopis tampak jaringan terfragmentasi dengan struktur papiler dan bercabang yang dilapisi oleh lebih dari 7 lapisan epitel transisional dengan inti pleomorfik dan sedikit ireguler, kromatin kasar, beberapa sitoplasma jernih dan aktivitas mitosis rendah. Stroma terdiri dari jaringan ikat fibrosa, dengan pembuluh darah dilatasi dan kongesti. Karcinoma urotelial papiler adalah neoplasma urotelial papiler dengan gangguan cytoarchitectural dalam berbagai tingkatan. Berdasarkan fitur histologis, diagnosis low grade papiler urotelial karsinoma dibuat. Selanjutnya, tumor ini memiliki risiko tinggi mengalami kekambuhan, dan kurang dari 15% pasien berkembang menjadi penyakit invasif. Non-invasive tumors represent the majority of primary bladder neoplasms during initial diagnosis. About 70-75% of new urothelial carcinomas are non-invasive and papillary with male to female ratio of 3:1. More than 50% of these tumors are low grade. We reported the case of a 53-year-old woman who complained of low back pain without hematuria. Then, bladder biopsy was done. Macroscopic examination revealed 1 cc of grayish mass with an uneven surface. Microscopic examination revealed fragmented tissue with a papillae and branched structure covered with more than 7 transitional epithelium layers with slightly irregular nuclei, rough chromatin, several clear cytoplasms and low mitotic activity. Stroma consists of fibrous connective tissue, with dilated blood vessels and congestion. Papillary urothelial carcinoma is papillary urothelial neoplasm with cytoarchitectural disorder in various levels. Based on histological features, a diagnosis of low grade papillary urothelial carcinoma was made. It was concluded that this tumor had a high risk of recurrence, and less than 15% of patients develop onto invasive disease.

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