scholarly journals Subcellular redistribution of trimeric G-proteins – potential mechanism of desensitization of hormone response; internalisation, solubilization, down-regulation

2008 ◽  
pp. S1-S10
Author(s):  
Z Drastichová ◽  
L Bouřová ◽  
V Lisý ◽  
L Hejnová ◽  
V Rudajev ◽  
...  
Keyword(s):  
G Proteins ◽  
G Protein Coupled Receptors ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Hormone Response ◽  
Ouabain Binding ◽  
Short Summary ◽  
Guanine Nucleotide Binding ◽  
G Protein Coupled ◽  
The Brain

Agonist-induced subcellular redistribution of G-protein coupled receptors (GPCR) and of trimeric guanine-nucleotide binding regulatory proteins (G-proteins) represent mechanisms of desensitization of hormone response, which have been studied in our laboratory since 1989. This review brings a short summary of these results and also presents information about related literature data covering at least small part of research carried out in this area. We have also mentioned sodium plus potassium dependent adenosine triphosphatase (Na, K-ATPase) and 3H-ouabain binding as useful reference standard of plasma membrane purity in the brain.

The guanine nucleotide-binding regulatory proteins (G proteins) in myocardium with ischemia

1996 ◽  
Vol 160-161 (1) ◽  
pp. 153-158 ◽  
Author(s):  
Mitsumasa Ohyanagi ◽  
Tadaaki Iwasaki
Keyword(s):  
G Proteins ◽  
Nucleotide Binding ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding

On the role of guanine nucleotide binding regulatory proteins (G-proteins) in signal transduction in platelets; studies with sodium fluoride (NaF)

1986 ◽  
Vol 41 ◽  
pp. 120
Author(s):  
J. Kienast ◽  
J. Arnout ◽  
H. Deckmyn ◽  
G. Pfliegler ◽  
B. Hoet ◽  
...  
Keyword(s):  
Signal Transduction ◽  
G Proteins ◽  
Sodium Fluoride ◽  
Nucleotide Binding ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding

Photoinduced receptor confinement drives ligand-independent GPCR signaling

Science ◽  
2021 ◽  
Vol 371 (6536) ◽  
pp. eabb7657
Author(s):  
M. Florencia Sánchez ◽  
Sylvia Els-Heindl ◽  
Annette G. Beck-Sickinger ◽  
Ralph Wieneke ◽  
Robert Tampé
Keyword(s):  
Cell Communication ◽  
Cellular Responses ◽  
Receptor Activation ◽  
G Protein Coupled Receptors ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding Protein ◽  
Lateral Membrane ◽  
Guanine Nucleotide Binding ◽  
G Protein Coupled

Cell-cell communication relies on the assembly of receptor-ligand complexes at the plasma membrane. The spatiotemporal receptor organization has a pivotal role in evoking cellular responses. We studied the clustering of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) and established a photoinstructive matrix with ultrasmall lock-and-key interaction pairs to control lateral membrane organization of hormone neuropeptide Y2 receptors in living cells by light. Within seconds, receptor clustering was modulated in size, location, and density. After in situ confinement, changes in cellular morphology, motility, and calcium signaling revealed ligand-independent receptor activation. This approach may enhance the exploration of mechanisms in cell signaling and mechanotransduction.

Mapping the Heart

2010 ◽  
Vol 18 (4) ◽  
pp. 6-8
Author(s):  
Stephen W. Carmichael
Keyword(s):  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
G Protein Coupled Receptors ◽  
Receptor Subtypes ◽  
Cardiac Muscle Cells ◽  
Guanine Nucleotide Binding Protein ◽  
The Common ◽  
Guanine Nucleotide Binding ◽  
First Time ◽  
G Protein Coupled

Some of the receptors on the surface of cardiac muscle cells (cardiomyocytes) mediate the response of these cells to catecholamines by causing the production of the common second messenger cyclic adenosine monophosphate (cAMP). An example of such receptors are the β1- and β2-adrenergic receptors (βARs) that are heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors. Selective stimulation of these two receptor subtypes leads to distinct physiological and pathophysiological responses, but their precise location on the surface of cardiomyocytes has not been correlated with these responses. In an ingenious combination of techniques, Viacheslav Nikolaev, Alexey Moshkov, Alexander Lyon, Michele Miragoli, Pavel Novak, Helen Paur, Martin Lohse, Yuri Korchev, Sian Harding, and Julia Gorelik have mapped the function of these receptors for the first time.

scholarly journals Signaling from G Protein-coupled Receptors to ERK5/Big MAPK 1 Involves Gαqand Gα12/13Families of Heterotrimeric G Proteins

2000 ◽  
Vol 275 (28) ◽  
pp. 21730-21736 ◽  
Author(s):  
Shigetomo Fukuhara ◽  
Maria Julia Marinissen ◽  
Mario Chiariello ◽  
J. Silvio Gutkind
Keyword(s):  
G Protein ◽  
G Proteins ◽  
G Protein Coupled Receptors ◽  
Heterotrimeric G Proteins ◽  
G Protein Coupled

G Proteins and G Protein-Coupled Receptors

2002 ◽  
pp. 181-197
Author(s):  
Michael A. Shetzline ◽  
Marc G. Caron
Keyword(s):  
G Protein ◽  
G Proteins ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

Mechanotransduction by Membrane-Mediated Activation of G-Protein Coupled Receptors and G-Proteins

2014 ◽  
pp. 89-119
Author(s):  
Yan-Liang Zhang ◽  
John A. Frangos ◽  
Mirianas Chachisvilis
Keyword(s):  
G Protein ◽  
G Proteins ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled
Sign in / Sign up

Export Citation Format

Share Document