scholarly journals Use of autologous platelet-rich plasma in treatment of genital forms of scleroatrophic lichen

2020 ◽  
pp. 41-46
Author(s):  
A. V. Ignatovsky ◽  
A. O. Zhelonkina ◽  
A. R. Zhelonkin
Keyword(s):  
Randomized Controlled Trials ◽  
Platelet Rich Plasma ◽  
Treatment Method ◽  
Controlled Trials ◽  
Lichen Sclerosis ◽  
Topical Corticosteroids ◽  
Randomized Controlled ◽  
Autologous Platelet Rich Plasma ◽  
New Treatment ◽  
Autologous Platelet

The article provides an overview of the use of platelet-rich plasma (PRP) for the treatment of lichen sclerosis (LS). The definition, principle of operation and main characteristics of this method are given. Studies showing the effectiveness of PRP method were analyzed. Based on our research, we believe that PRP may be an alternative to treatment with topical corticosteroids. The method is a new treatment method for LS, which requires further randomized controlled trials.

scholarly journals A guide to do randomized controlled trials in the field of otolaryngology

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Sameh M. Zamzam ◽  
Mosaad Abdel-Aziz ◽  
Ahmed Atef ◽  
Usama Abdel-Naseer ◽  
Mostafa Hamoda ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Study Groups ◽  
Controlled Trials ◽  
Main Body ◽  
Main Research ◽  
Randomized Controlled ◽  
New Treatment ◽  
Meta Analyses ◽  
Based Medicine

Abstract Background Randomized controlled trials (RCTs) are prospective comparative studies in which study groups are allocated randomly to intervention or serve as controls. RCT is the mainstay to achieve evidence in the literature in clinical research. A RCT is the main research design to study the effect of an intervention and the only way to confirm the value of a new treatment. Main body RCT also gives the way to generate meta-analyses and systematic reviews giving a stronger evidence for clinical practice. Evidence-based medicine (EBM) is crucial for safe, effective, and standardized patient care. Although there is an agreement on the importance of performing RCT, it can be challenging to do it efficiently including different aspects like study design, funding, randomization, blinding, follow-up, data analysis, statistics, generalization of results, and reporting of quality of the studies. Conclusion In this article, we gave a comprehensive review for RCT in otolaryngology discussing their importance, advantages, and drawbacks, types, steps, challenges, reporting their quality and their prevalence in the literature.

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