This chapter reviews the assessment of psychopathology, with a focus on psychosis and clinically related phenomena and conditions, such as prodromal phases and at-risk mental states of psychosis. The psychosis syndrome, which is characterized by a disruption of higher cognitive functions, can be found when any basic psychological process (e.g., memory, attention, etc.) is altered. It is used here as an example of psychopathological disorder. The chapter begins with an overview of the psychosis syndrome as a model of psychopathological disorder, emphasizing its core domains (i.e., positive, negative, and cognitive symptoms). It discusses the main psychological tests and procedures for psychosis assessment and provides an overall review of measurement instruments for psychosis risk assessment from both clinical and psychometric high-risk paradigms, where psychological testing plays a crucial role in terms of detecting people at risk for psychosis prior to developing serious mental disorder and need for care.