Preparation of water soluble Chitosan derivatives  by Millard reaction and identify its by GC-MS and Test its as antioxidant

Nitroxide spin labels have been attached to chitin, chitosan, and their derivatives in order to investigate the solution and gel characteristics of these polymers. Thus, chitin was nonselectively acylated using the chloroacetamide label 3 to afford. the corresponding nitroxide derivative 4. Selective and nonselective labelling of chitosan was accomplished either via reductive alkylation using the keto label 5 and sodium cyanoborohydride or via a chitosan sulfate intermediate using labels 3 or 5. Two branched water soluble chitosan derivatives, carrying C-6 oxidized, terminal galactose side chains were selectively labelled by reductive animation using the amine label 13 to yield derivatives 14 and 15. Motional correlation values of the covalently-linked nitroxide moieties were shown to reflect the nature of the linkage between spin label and polymer, as well as structural differences between the branch residues of derivatives 14 and 15. The spin-probe – spin-label method was employed to demonstrate structural heterogeneities for the chitosan derivatives 7 and 15.

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THE FORMATION OF HYDROGELS BASED ON CHITOSAN AND ITS WATER-SOLUBLE DERIVATIVES

Progress on Chemistry and application of Chitin and its Derivatives ◽

10.15259/pcacd.25.001 ◽

2020 ◽

Vol XXV ◽

pp. 5-15

Keyword(s):

Noncovalent Interactions ◽

Water Soluble ◽

Production Costs ◽

Medical Applications ◽

Covalent Bonds ◽

Chitosan Derivatives ◽

Ph Values ◽

Extended Range ◽

Low Toxicity ◽

Physically Crosslinked

This review considers articles on the formation of hydrogels based on chitosan as well as succinylated and quaternized chitosan derivatives. They are synthesized using low toxicity reagents, under ordinary conditions (low production costs). Chitosan derivatives are soluble in an extended range of pH values and characterized by mucoadhesiveness, bioavailability and biodegradability, which extends the potential of their medical applications. One of the most important properties of chitosan and its derivatives is the ability to form hydrogels. Depending on the nature of the bonds that occur during formation, hydrogels are divided into chemically or physically crosslinked, or a mixture of the two. Chemically crosslinked gels have covalent bonds, while physically crosslinked gels are formed by noncovalent interactions, for example, ionic. Mixed hydrogels have both types of crosslinking.

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Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA

Drug Delivery ◽

10.1080/10717544.2018.1440668 ◽

2018 ◽

Vol 25 (1) ◽

pp. 644-653 ◽

Cited By ~ 9

Author(s):

Victoria Capel ◽

Driton Vllasaliu ◽

Peter Watts ◽

Philip A. Clarke ◽

Dominic Luxton ◽

...

Keyword(s):

Water Soluble ◽

Chitosan Derivatives ◽

Technology Platform ◽

Inhalation Delivery

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ADME-Tox profiling of some water soluble chitosan derivatives

ADMET & DMPK ◽

10.5599/admet.5.3.423 ◽

2017 ◽

Vol 5 (3) ◽

pp. 192 ◽

Cited By ~ 1

Author(s):

Adriana Isvoran ◽

Alecu Aurel Ciorsac ◽

Vasile Ostafe

Keyword(s):

Skin Penetration ◽

Gastrointestinal Toxicity ◽

Water Soluble ◽

Low Molecular Weight ◽

Computational Tools ◽

Chitosan Derivatives ◽

Professional Exposure ◽

Low Probability ◽

Metabolism Of Xenobiotics ◽

Derivatives Of

Within this study we use a few computational tools for predicting absorption, distribution, metabolism, excretion and toxicity (ADME-Tox), pharmacokinetics profiles, toxic/adverse effects, carcinogenicity, cardiotoxicity and endocrine disruption of some of low molecular weight water soluble derivatives of chitosan that are used in wound healing. Investigated compounds do not possess drug-like properties, their pharmacokinetics profiles reveal poor gastrointestinal absorption and low skin penetration. Chitosan derivatives cannot pass the blood-brain barrier and they are not able to inhibit the enzymes of the cytochrome P450 that are involved in the metabolism of xenobiotics. They do not reflect carcinogenicity and cardiotoxicity and reveal only a low probability to be endocrine disruptors. The main side effects in humans of the investigated compounds are: weight loss, acidosis, gastrointestinal toxicity, respiratory failure. This information is especially important for professional exposure and accidental contamination with these compounds.

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Antibacterial Characteristics and Activity of Water-Soluble Chitosan Derivatives Prepared by the Maillard Reaction

Molecules ◽

10.3390/molecules16108504 ◽

2011 ◽

Vol 16 (10) ◽

pp. 8504-8514 ◽

Cited By ~ 47

Author(s):

Ying-Chien Chung ◽

Jan-Ying Yeh ◽

Cheng-Fang Tsai

Keyword(s):

Maillard Reaction ◽

Water Soluble ◽

Chitosan Derivatives

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