scholarly journals A 3-year Randomized Clinical Trial of MiSight Lenses for Slowing Myopia Progression

The Eye ◽  
2020 ◽  
Vol 22 (4(132)) ◽  
pp. 11-28
Author(s):  
P. Chamberlain ◽  
Sofia C. Peixoto-de-Matos ◽  
N. S. Logan ◽  
Ch. Ngo ◽  
D. Jones ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Contact Lens ◽  
Axial Length ◽  
Test Group ◽  
Control Group ◽  
Spherical Equivalent ◽  
Soft Contact ◽  
Myopia Progression ◽  
Soft Contact Lens ◽  
Spherical Equivalent Refraction

Significance. Results of this randomized, double-masked clinical trial demonstrate the effectiveness of the MiSight soft contact lens in slowing myopia progression over multiple years.Purpose. The purpose of this study was to quantify the effectiveness of MiSight daily disposable soft contact lens in slowing the progression of juvenile-onset myopia.Methods. Myopic children (spherical equivalent refraction, −0.75 to −4.00 D; astigmatism, < 1.00 D) aged 8 to 12 years with no prior contact lens experience were enrolled in a 3-year, double-masked, randomized clinical trial at four investigational sites in four countries. Subjects in each group were matched for age, sex, and ethnicity and were randomized to either a MiSight®1 day contact lens (test) or Proclear®1 day (control; omafilcon A) and worn on a daily disposable basis. Primary outcome measures were the change in cycloplegic spherical equivalent refraction and axial length.Results. Of the subjects enrolled, 75.5% (109/144) completed the clinical trial (53 test, 56 control). Unadjusted change in spherical equivalent refraction was −0.73 D (59%) less in the test group than in the control group (−0.51 ± 0.64 vs. –1.24 ± 0.61 D, P < 0.001). Mean change in axial length was 0.32 mm (52%) less in the test group than in the control group (0.30 ± 0.27 vs. 0.62 ± 0.30 mm, P < 0.001). Changes in spherical equivalent refraction and axial length were highly correlated (r = −0.90, P < .001). Over the course of the study, there were no cases of serious ocular adverse events reported. Four asymptomatic corneal infiltrative (one test, three control) events were observed at scheduled study visits.Conclusions. Results of this clinical trial demonstrate the effectiveness of the MiSight daily disposable soft contact lens in slowing change in spherical equivalent refraction and axial length.

scholarly journals Treatment of Rapid Progression of Myopia: Case Series and Literature Review

2021 ◽  
pp. 875-881
Author(s):  
Nir Erdinest ◽  
Naomi London ◽  
Nadav Levinger ◽  
Itay Lavy ◽  
Eran Pras ◽  
...  
Keyword(s):  
Contact Lens ◽  
Axial Length ◽  
Contact Lenses ◽  
Case Series ◽  
Rapid Progression ◽  
Retrospective Case ◽  
Soft Contact ◽  
Myopia Progression ◽  
Current Case ◽  
Soft Contact Lens

This retrospective case series demonstrates the combination of 0.05% atropine with MiSight<sup>®</sup> 1 day (Cooper vision, Sar Ramon, CA, USA) in rapid progression of myopia of 4 children. MiSight<sup>®</sup> 1 day is a peripheral defocus, center-distance soft contact lens and is effective at controlling moderate progression of myopia during the course of 1 year. The current case series included 2 females and 2 males with an average age of 9.68 ± 0.26 years and an average axial length of 24.81 ± 0.92 mm. Their myopic progression during the previous year was −1.45 ± 0.27 D. The children had not attempted any myopia control thus far. This relatively high increase prompted a combination treatment of daily instillation of 0.05% atropine and MiSight, a daily replacement soft contact lens. Cycloplegic refraction and a slit-lamp evaluation were performed every 6 months to confirm no adverse reactions or staining was present. The 8-item contact lens dry eye questionnaire (CLDEQ-8) score of these children was 10.66 ± 1.52. The average myopia progression at the end of 1 year decreased to −0.41 ± 0.11 D, and the average axial length increase was 0.28 ± 0.08 mm. To the best of the authors’ knowledge, this is the first published study showing a combination of 0.05% atropine and peripheral defocus soft contact lenses indicating efficacy at controlling moderate myopia progression.

Topical atropine in retarding myopia progression and axial length growth in children with myopia

2020 ◽  
Vol 13 (4) ◽  
pp. 111-114
Author(s):  
Abdur Rahman Mohammad Alam ◽  
Md. Sanwar Hossain ◽  
Md. Shafiqul Islam
Keyword(s):  
Axial Length ◽  
Control Group ◽  
Refractive Errors ◽  
Spherical Equivalent ◽  
Myopia Progression ◽  
Length Growth ◽  
Significant Difference ◽  
The Mean ◽  
And Control

This study was conducted to observe the effect of atropine in retarding myopia progression and axial length growth in 36 myopic children (atropine group, 24; control, 12). The initial spherical equivalent of the atropine group and control group was -3.0 ± 1.6 dioptre and -3.5 ± 1.6 dioptre respectively. At the 12th month in atropine group, it was -2.9 ± 2.6 dioptre and -4.6 ± 1.9 dioptre in the control group. The power of the atropine group reduced but rose in the control group after 12 months. There was a statistically significant difference in final refractive errors between the two groups (p<0.05). The initial axial length of the atropine group and control group was 24.3± 1.0 mm and 24.6 ± 1.1 mm respectively. In 12th month, the changes in axial length in the two groups was insignificant. However, the mean axial length progression at 12 months of the atropine group was -0.1 ± 0.1 mm and it was lower than the control group which was -0.2 ± 0.2 mm, and this was statistically significant (p<0.05). In conclusion, topical atropine (0.01%) retarded myopia progre-ssion and axial length growth in myopic children.    

scholarly journals Myopia Progression During Three Years of Soft Contact Lens Wear

2009 ◽  
Vol 86 (10) ◽  
pp. 1150-1153 ◽  
Author(s):  
Adam Blacker ◽  
G Lynn Mitchell ◽  
Mark A. Bullimore ◽  
Bill Long ◽  
Joseph T. Barr ◽  
...  
Keyword(s):  
Contact Lens ◽  
Soft Contact ◽  
Myopia Progression ◽  
Contact Lens Wear ◽  
Soft Contact Lens ◽  
Lens Wear

Efficacy and safety of a soft contact lens to control myopia progression

2020 ◽  
Author(s):  
Alba M Garcia‐del Valle ◽  
Vanesa Blázquez ◽  
Juan Gros‐Otero ◽  
Mónica Infante ◽  
Antonio Culebras ◽  
...  
Keyword(s):  
Contact Lens ◽  
Efficacy And Safety ◽  
Soft Contact ◽  
Myopia Progression ◽  
Soft Contact Lens

scholarly journals Assessment of Corneal Epithelial Thickness in Chronic Contact Lens Users Using Anterior Segment Optical Coherence Tomography

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A A M E A Rezk ◽  
A Assaf ◽  
M Gamil ◽  
T Badran
Keyword(s):  
Contact Lens ◽  
Corneal Epithelium ◽  
Refractive Surgery ◽  
Anterior Segment ◽  
Control Group ◽  
Soft Contact ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Soft Contact Lens ◽  
Corneal Epithelial Thickness

Abstract Introduction The corneal epithelium is stratified epithelium that is continuously renewed and provides the frontline of defence against invading ocular pathogens and a smooth refractive surface essential for vision. In the absence of a contact lens, pre-existing ocular trauma or disease, the epithelium maintains an inaccessible defence against attacks from pathogenic microorganisms, affording a high level of resistance against microbial invasion. Aim The aim of this study is to determine the effect of chronic use of contact lens on corneal epithelium thickness using anterior segment optical coherence topography as a non- invasive diagnostic accurate measure. Patients and Methods 30 eyes of control subjects who don’t wear contact lens along their life aged between 15-45 years ,where compared with similar age group of 30 eyes of chronic contact lens users; who wear contact lens every day not less than 8 hours per day for along time interval between 6 months up to 5 years. Results The average corneal epithelial thickness in the central, paracentral and midperipheral zones was 47.767 ± 5.550 µm, 46.267 ± 5.644 µm, 44.300 ± 4.858 µm, respectively, in chronic soft contact lens users; and 49.800 ± 3.316 µm, 49.200 ± 3.367 µm, 45.733 ± 2.333 µm ,in control group who had never worn contact lens. There were insignificant thinning of corneal epithelium of soft contact group compared to control group regarding the average corneal epithelial thickness in those 3 zones. In all the 8 sectors of corneal epithelium of paracentral zone and midperipheral zones there is insignificant thinning between the two groups except for the inferior temporal sector in the paracentral zone and mid peripheral zone, which shows significant thinning in soft contact lens group compared to control group. The corneal epithelial thickness in the inferior temporal sector of paracentral and mid peripheral zones was 46.333 ± 5.677 µm, 44.933 ± 4.813 µm, respectively, in chronic soft contact lens users compared to 48.767 ± 3.266 µm, 46.900 ± 2.510 µm in control group (p = 0.046, p = 0.052, respectively). Conclusion AS-OCT helps us to evaluate the corneal epithelium of contact lens users, which could be very useful in corneal refractive surgeries in patients depending on contact lens in their lives as a comfortable refractive aid, It is necessary to do AS-OCT hand on hand with pentacam in patients underwhelming refractive surgery to give a proper assessment to their corneal epithelium before determining which type of refractive surgery suits them.

scholarly journals Ocular and Corneal Aberrations changes in controlled randomized clinical trial MiSight® Assessment Study Spain (MASS)

2020 ◽  
Author(s):  
DANIELA LOPES-FERREIRA ◽  
Alicia Ruiz-Pomeda ◽  
Belén Peréz-Sanchéz ◽  
António Queirós ◽  
César Villa-Collar
Keyword(s):  
Clinical Trial ◽  
Axial Length ◽  
Contact Lenses ◽  
Spherical Aberration ◽  
High Order ◽  
Control Group ◽  
Myopia Progression ◽  
Corneal Aberrations ◽  
Single Vision ◽  
Low Order

Abstract BackgroundTo compare ocular and corneal inherent aberrations in the naked eyes of randomly selected children fitted with MiSight contact lenses (CL) for myopia control, versus children corrected with single-vision spectacles (control), over a 24-months period.MethodsChildren aged 8 to 12 years, with myopia (-0.75 to -4.00 D sphere) and astigmatism (< -1.00 D cylinder), were assigned to the lens study group (MiSight) or the control group (single-vision spectacles). Axial length (AL) was measured by biometry, corneal RMS (RMS_C), corneal high order RMS (HO_RMS_C), corneal low order RMS (LO_RMS_C), ocular total RMS (RMS_T), ocular total high order RMS (HO_RMS_T), ocular total low order RMS (LO_RMS_T), corneal spherical aberration (SA_C) and ocular total SA (SA_T) were calculated by aberrometric measures at the baseline, and on 12- and 24-months visits. A 5 mm diameter was defined for the analysis in all visits for all subjects. Only the dominant eye was analyzed.ResultsSeventy-four subjects completed the clinical trial: 41 subjects from the MiSight group (age: 11.01 ± 1.23 years) and 33 from the single-vision group (age: 10.12 ± 1.38 years). In the control group, axial length changed significantly (0.444 ± 0.049 mm, p < 0.001) after 2 years. Also RMS_T (0.565 ± 0.199 µm, p = 0.029) and LO_RMS_T (0.461 ± 0.175 µm, p = 0.047) registered significant changes after 24-months in the control group. In the MiSight group, only axial length changed significantly (0.284 ± 0.025 mm, p < 0.001) after 2 years. The SA_C and SA_T did not reveal significant changes between visits or between groups.ConclusionsThe wear of MiSight CL did not induce significant changes in aberrations in anterior cornea and contrary of control group the total ocular RMS and low order RMS did not significantly caused by significantly lower eye growth and myopia progression,Trial registration: ClinicalTrials.gov Identifier: NCT01917110.

scholarly journals The Effects of Soft Contact Lens Wear on Corneal Thickness, Curvature, and Surface Regularity

2014 ◽  
Vol 4 (2) ◽  
pp. 35-39
Author(s):  
RP Sah ◽  
N Paudel ◽  
M Chaudhary ◽  
P Adhikari ◽  
SK Mishra
Keyword(s):  
Contact Lens ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Corneal Topography ◽  
Control Group ◽  
Soft Contact ◽  
Contact Lens Wear ◽  
Soft Contact Lens ◽  
The Mean ◽  
Lens Wear

Contact lenses have various cosmetic and optical advantages over spectacles. However, long term lens use might affect the normal corneal anatomy and physiology in a variety of ways. The aim of this study was to determine the effect of soft contact lens wear on corneal thickness, curvature, and surface regularity.A total of 138 eyes of 69 subjects wearing contact lenses for more than 1 year were evaluated. One eye of each case was randomly selected for the analysis. Nidek Magellan Mapper corneal topography system was used to evaluate the anterior corneal topography. Central corneal thickness (CCT) was measured using Quantel Medical Axis II PR. Corneal topography and CCT measurements on 138 eyes of 69 subjects were performed. The mean age of the cases and controls was 24.76 ± 5.52 25.13±5.49 years respectively. The mean dura­tion of contact lens wear was 4.83±4.19 years. The mean CCT in case and control group was 527.56±37.40 microns and 544.60±26.10 microns respectively. The mean central corneal thickness in the cases was significantly less by about 16.31 μm in comparison to controls (P <0.05, 95% CI of the difference: 9 μm - 24μm). The SRI and SAI indices were significantly greater in contact lens wearers than in the control group (P = 0.00 for both SRI and SAI).Regular corneal pachymetry and topography assessments are mandatory in soft contact lens users as long term lens wear appears to reduce the central corneal thickness and increase the corneal surface irregularity. DOI: http://dx.doi.org/10.3126/jcmc.v4i2.10861 Journal of Chitwan Medical College 2014; 4(2): 35-39

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