scholarly journals Influence on Performance of Three to Six-Week-Old Broilers of Varying Dietary Protein Contents with Supplementation of Essential Amino Acid Requirements

1989 ◽  
Vol 68 (1) ◽  
pp. 113-123 ◽  
Author(s):  
BRYAN I. FANCHER ◽  
LEO S. JENSEN
Keyword(s):  
Amino Acid ◽  
Dietary Protein ◽  
Essential Amino Acid ◽  
Amino Acid Requirements

scholarly journals Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1469
Author(s):  
Patricia M. Rusu ◽  
Andrea Y. Chan ◽  
Mathias Heikenwalder ◽  
Oliver J. Müller ◽  
Adam J. Rose
Keyword(s):  
Amino Acid ◽  
Growth Factor ◽  
Dietary Protein ◽  
Essential Amino Acid ◽  
De Novo ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
De Novo Biosynthesis ◽  
Dietary Requirements ◽  
Dietary Amino Acid

Prior studies have reported that dietary protein dilution (DPD) or amino acid dilution promotes heightened water intake (i.e., hyperdipsia) however, the exact dietary requirements and the mechanism responsible for this effect are still unknown. Here, we show that dietary amino acid (AA) restriction is sufficient and required to drive hyperdipsia during DPD. Our studies demonstrate that particularly dietary essential AA (EAA) restriction, but not non-EAA, is responsible for the hyperdipsic effect of total dietary AA restriction (DAR). Additionally, by using diets with varying amounts of individual EAA under constant total AA supply, we demonstrate that restriction of threonine (Thr) or tryptophan (Trp) is mandatory and sufficient for the effects of DAR on hyperdipsia and that liver-derived fibroblast growth factor 21 (FGF21) is required for this hyperdipsic effect. Strikingly, artificially introducing Thr de novo biosynthesis in hepatocytes reversed hyperdipsia during DAR. In summary, our results show that the DPD effects on hyperdipsia are induced by the deprivation of Thr and Trp, and in turn, via liver/hepatocyte-derived FGF21.

Whole-body leucine and lysine metabolism: response to dietary protein intake in young men

1981 ◽  
Vol 240 (6) ◽  
pp. E712-E721 ◽  
Author(s):  
K. J. Motil ◽  
D. E. Matthews ◽  
D. M. Bier ◽  
J. F. Burke ◽  
H. N. Munro ◽  
...  
Keyword(s):  
Amino Acid ◽  
Dietary Protein ◽  
Protein Intake ◽  
Whole Body ◽  
Dietary Protein Intake ◽  
Body Protein ◽  
Fed State ◽  
Amino Acid Requirements ◽  
Maintenance Requirements ◽  
Lysine Metabolism

Whole-body leucine and lysine metabolism was explored in young adult men by a primed constant intravenous infusion of a mixture of L-[1–13C]leucine and L-[alpha-15N]lysine over a 4-h period. Subjects were studied after an overnight fast (postabsorptive state) or while consuming hourly meals (fed state) after adaptation to diets providing either a surfeit level of protein (1.5 g.kg body-1.day-1), a level approximating maintenance requirements (marginal intake) (0.6 g.kg body wt-1.day-1), or a grossly inadequate level (0.1 g.kg-1.day-1). The change in protein intake from a marginal to a surfeit level was associated with an increased leucine flux and incorporation of leucine into body protein. In the fed state, oxidation of leucine increased sharply and release of leucine from tissue protein diminished. When dietary protein intake was reduced from the requirement to inadequate level, leucine flux and body protein synthesis and protein breakdown were reduced, together with a smaller reduction in leucine oxidation. The response of the metabolism of [15N]lysine was responsible for maintenance of leucine and other essential amino acid economy, and they appear to be related to the nitrogen and amino acid requirements of the subject. These findings also demonstrate an effect of meals, modulated by their protein content, on the dynamics of whole-body amino acid metabolism.

scholarly journals Amino Acid Characteristics of Nigerian Local Cheese (‘Wara’)

2021 ◽  
pp. 1-8
Author(s):  
Adeyeye EI ◽  
◽  
Idowu OT ◽  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Essential Amino Acid ◽  
Crude Protein ◽  
Milk Protein ◽  
Quality Parameters ◽  
Cow Milk ◽  
Amino Acid Requirements ◽  
Excellent Source ◽  
Better Than

This article reports the amino acid composition of the Nigerian local cheese called ‘wara’. ‘Wara’ is made by boiling cow milk with some added coagulant to cuddle the milk protein resulting in coagulated milk protein and whey. ‘Wara’ used to be an excellent source of nutrients such as proteins, fats, minerals and vitamins. Samples were purchased in Ado-Ekiti, Nigeria. Amino acid values were high (g/100g crude protein) in Leu, Asp, Glu, Pro, Phe, Arg with total value of 97.7. The quality parameters of the amino acids were: TEAA (42.6g/100g and 43.6%) whereas TNEAA (55.1g/100g and 56.4%); TArAA (12.8g/100g and 13.1%); TBAA (14.2g/100g and 14.5%); TSAA (3.10g/100g and 3.17%); %Cys in TSAA (51.4); Leu/Ile ratio (1.74); P-PER1 (2.65); P-PER2 (2.48); P-PER3 (2.41); EAAI1 (soybean standard) (1.29) and EAAI2 (egg standard) (99.9); BV (97.2) and Lys/Trp ratio (3.62). The statistical analysis of TEAA/TNEAA at r=0.01 was not significantly different. On the amino acid scores, Met was limiting (0.459) at egg comparison, Lys was limiting at both FAO/WHO [24] and preschool EAA requirements with respective values of 0.966 and 0.97. Estimates of essential amino acid requirements at ages 10-12 years (mg/kg/day) showed the ‘wara’ sample to be better than the standard by 3.72-330% with Lys (3.72%) being least better and Trp (330%) being most. The results showed that ‘wara’ is protein-condensed which can be eaten as raw cheese, flavoured snack, sandwich filling or fried cake.

The Essential Amino Acid Requirements of Infants

1964 ◽  
Vol 15 (6) ◽  
pp. 322-330 ◽  
Author(s):  
SELMA E. SNYDERMAN ◽  
AUDREY BOYER ◽  
PATRICIA M. NORTON ◽  
ELLEN ROITMAN ◽  
L. EMMETT HOLT
Keyword(s):  
Amino Acid ◽  
Essential Amino Acid ◽  
Amino Acid Requirements

Amino acid requirements of the growing meat rabbit 1. The amino acid composition of rabbit whole-body tissue — a theoretical estimate of ideal amino acid balance

1988 ◽  
Vol 47 (2) ◽  
pp. 297-301 ◽  
Author(s):  
P. J. Moughan ◽  
W. H. Schultze ◽  
W. C. Smith
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Essential Amino Acid ◽  
Theoretical Estimate ◽  
Body Tissue ◽  
Whole Body ◽  
Methionine Concentration ◽  
Amino Acid Requirements ◽  
Amino Acid Balance

ABSTRACTWhole-body amino acid composition was determined in six male and six female 53-day-old New Zealand White rabbits. There were no significant sex differences in whole-body amino acid compositition except for arginine and glycine where whole-body concentrations (g/16 g N) were significantly lower in the females (P < 0·05). Overall mean whole-body essential amino acid levels (relative to lysine = 100 units) were methionine = 20; cystine = 41; histidine = 50; phenylalanine = 65; tyrosine = 50; threonine = 64; leucine = 112; isoleucine = 51; valine = 62; arginine = 109. The lysine concentration of rabbit whole-body tissue was 6·12 g/16 g N. There was close agreement between rabbit whole-body amino acid composition and corresponding published values for the rat and pig, although the rabbit whole-body cystine was high and methionine concentration low compared with the rat or pig. The rabbit whole-body amino acid pattern can be regarded as approximating an ideal balance of dietary amino acids and as such indicates discrepancies in current recommendations on the essential amino acid requirements for growth in the meat rabbit.

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