Laron syndrome – A case Report

JMS SKIMS ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 104-106
Author(s):  
Javaid Ahmad Bhat ◽  
Moomin Hussain Bhat ◽  
Hilal Bhat ◽  
Mona Sood ◽  
Shariq Rashid Masoodi
Keyword(s):  
Growth Hormone ◽  
Case Report ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Genetic Disorder ◽  
Female Child ◽  
Receptor Signaling ◽  
Laron Syndrome ◽  
Rare Genetic Disorder ◽  
Igf I

Background : Laron & colleagues (1966) reported a rare genetic disorder in Israliei Jewish sublings which was characterized by insensitivity to growth hormone due to abnormality in growth hormone receptor or post receptor signaling pathway.Case Report: We hereby report a case of a 5 year old female child who presented to us with features similar to Laron syndrome. The diagnosis was made & confirmed by various Lab. investigations like low IGF-I levels and managed accordingly. JMS 2017; 20 (2):104-106  

Serum lipoprotein changes following IGF-I normalization using a growth hormone receptor antagonist in acromegaly

2002 ◽  
Vol 56 (3) ◽  
pp. 303-311 ◽  
Author(s):  
C. Parkinson ◽  
W. M. Drake ◽  
G. Wieringa ◽  
A. P. Yates ◽  
G. M. Besser ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Receptor Antagonist ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Serum Lipoprotein ◽  
Igf I ◽  
Growth Hormone Receptor Antagonist

scholarly journals Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice

2010 ◽  
Vol 120 (11) ◽  
pp. 4007-4020 ◽  
Author(s):  
Mahendra D. Mavalli ◽  
Douglas J. DiGirolamo ◽  
Yong Fan ◽  
Ryan C. Riddle ◽  
Kenneth S. Campbell ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Muscle Development ◽  
Receptor Signaling ◽  
Skeletal Muscle Development

scholarly journals Dairy cows experience selective reduction of the hepatic growth hormone receptor during the periparturient period

2004 ◽  
Vol 181 (2) ◽  
pp. 281-290 ◽  
Author(s):  
J Wook Kim ◽  
RP Rhoads ◽  
SS Block ◽  
TR Overton ◽  
SJ Frank ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Growth Hormone ◽  
Dairy Cows ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Late Pregnancy ◽  
Target Tissue ◽  
Ghr Gene ◽  
Igf I

At parturition, dairy cows experience a 70% reduction in plasma IGF-I. This reduction coincides with decreased abundance of GHR1A, the liver-specific transcript of the growth hormone receptor (GHR) gene, suggesting impaired growth hormone-dependent synthesis of IGF-I. It is not immediately obvious that the periparturient reduction in GHR1A is sufficient to reduce hepatic GHR abundance. This is because approximately 50% of total GHR mRNA abundance in prepartum liver is accounted for by ubiquitously expressed transcripts which remain collectively unchanged at parturition. In addition, the possibility that parturition alters GHR expression in other growth hormone target tissue has not been examined. To address these questions, we measured GHR gene expression and GHR protein in liver and skeletal muscle of four dairy cows on days -35,+3 and+56 (relative to parturition on day 0). Hepatic GHR abundance and GHR1A transcripts were lower on day+3 than on day -35 and returned to late pregnancy value by day+56. Additional studies in two other groups of cows indicated that the hepatic levels of the GHR protein recovered substantially within 10 days after parturition. These changes occurred without variation in the abundance of HNF4, a liver-enriched transcription factor activating the promoter responsible for GHR1A synthesis. In contrast to liver, levels of GHR gene expression and GHR protein were identical on days -35,+3 and+56 in skeletal muscle. These data suggest a role for the GHR in regulating tissue-specific changes in growth hormone responsiveness in periparturient dairy cows.

scholarly journals Protein-tyrosine Phosphatase H1 Controls Growth Hormone Receptor Signaling and Systemic Growth

2007 ◽  
Vol 282 (48) ◽  
pp. 35405-35415 ◽  
Author(s):  
Iwona Pilecka ◽  
Claudia Patrignani ◽  
Rosanna Pescini ◽  
Marie-Laure Curchod ◽  
Dominique Perrin ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Protein Tyrosine Phosphatase ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Tyrosine Phosphatase ◽  
Receptor Signaling ◽  
Protein Tyrosine

scholarly journals Growth Without Growth Hormone Receptor: Estradiol Is a Major Growth Hormone-Independent Regulator of Hepatic IGF-I Synthesis

2005 ◽  
Vol 20 (12) ◽  
pp. 2138-2149 ◽  
Author(s):  
Katrien Venken ◽  
Frans Schuit ◽  
Leentje Van Lommel ◽  
Katsura Tsukamoto ◽  
John J Kopchick ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Igf I
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