Immune Checkpoint Inhibitor (ICPI) induced Nephrotoxicity – An Insight.

Immune check point inhibitors (ICPIs) are a new class of anti-neoplastic agents being increasingly used by oncologists to treat various malignancies. These drugs have been associated with varied side effects and have a nephrotoxic potential. Many cases of ICPI induced acute kidney injury are increasingly being reported. Their use in CKD patients on dialysis as well as in kidney transplant recipients is associated with various challenges. This review discusses the use of ICPIs in CKD, dialysis and renal transplant patients and their nephrotoxic potential

Download Full-text

FP784LONG TERM GRAFT FUNCTION IN KIDNEY TRANSPLANT RECIPIENTS OF DECEASED DONORS WITH ACUTE KIDNEY INJURY

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfz106.fp784 ◽

2019 ◽

Vol 34 (Supplement_1) ◽

Author(s):

Reinis Lulle ◽

Gritane Klinta ◽

Asare Lasma ◽

Jushinskis Janis ◽

Malcevs Aleksandrs ◽

...

Keyword(s):

Acute Kidney Injury ◽

Kidney Transplant ◽

Graft Function ◽

Kidney Injury ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Deceased Donors

Download Full-text

Validation of Administrative Database Codes for Acute Kidney Injury in Kidney Transplant Recipients

Canadian Journal of Kidney Health and Disease ◽

10.1186/s40697-016-0108-7 ◽

2016 ◽

Vol 3 ◽

pp. 108 ◽

Cited By ~ 10

Author(s):

Amber O. Molnar ◽

Carl van Walraven ◽

Eric McArthur ◽

Dean Fergusson ◽

Amit X. Garg ◽

...

Keyword(s):

Acute Kidney Injury ◽

Kidney Transplant ◽

Kidney Injury ◽

Administrative Database ◽

Transplant Recipients ◽

Kidney Transplant Recipients

Download Full-text

A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts

Journal of Clinical Medicine ◽

10.3390/jcm9092986 ◽

2020 ◽

Vol 9 (9) ◽

pp. 2986 ◽

Cited By ~ 2

Author(s):

Smaragdi Marinaki ◽

Stathis Tsiakas ◽

Maria Korogiannou ◽

Konstantinos Grigorakos ◽

Vassilios Papalois ◽

...

Keyword(s):

Kidney Transplant ◽

Distress Syndrome ◽

Kidney Injury ◽

Deceased Donor ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Male Predominance ◽

Transplant Patients ◽

Kidney Transplant Patients ◽

The Mean

The coronavirus disease 2019 (COVID-19) pandemic has posed a significant challenge to physicians and healthcare systems worldwide. Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until 7 July 2020, reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of patients was 55 ± 15 years. There was a male predominance (67%). The majority (74%) were deceased donor recipients, and 23% were recently transplanted (<1 year). Most patients (88%) had at least one comorbidity, 29% had two, and 18% three. Ninety-three percent of cases were hospitalized. Among them, 30% were admitted to the intensive care unit, 45% developed acute respiratory distress syndrome, and 44% had acute kidney injury with 23% needing renal replacement therapy. From the hospitalized patients a total of 22% died, 59% were discharged, and 19% were still in hospital at the time of publication. Immunosuppression was reduced in 27%, discontinued in 31%, and remained unchanged in 5%. Hydroxychloroquine was administered to 78% of patients, antibiotics to 73%, and antivirals to 30% while 25% received corticosteroid boluses, 28% received anti-interleukin agents, and 8% were given immunoglobulin. The main finding of our analysis was that the incidence of COVID-19 among kidney transplant patients is not particularly high, but when they do get infected, this is related to significant morbidity and mortality.

Download Full-text

Hospital Admission following Acute Kidney Injury in Kidney Transplant Recipients Is Associated with a Negative Impact on Graft Function after 1-Year

PLoS ONE ◽

10.1371/journal.pone.0138944 ◽

2015 ◽

Vol 10 (9) ◽

pp. e0138944 ◽

Cited By ~ 11

Author(s):

Thiago Corsi Filiponi ◽

Lúcio Roberto Requião-Moura ◽

Eduardo José Tonato ◽

Ana Cristina Carvalho de Matos ◽

Alvaro Pacheco e Silva-Filho ◽

...

Keyword(s):

Acute Kidney Injury ◽

Hospital Admission ◽

Kidney Transplant ◽

Negative Impact ◽

Graft Function ◽

Kidney Injury ◽

Transplant Recipients ◽

Kidney Transplant Recipients

Download Full-text

Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm10215162 ◽

2021 ◽

Vol 10 (21) ◽

pp. 5162

Author(s):

Jia-Jin Chen ◽

George Kuo ◽

Tao Han Lee ◽

Huang-Yu Yang ◽

Hsin Hsu Wu ◽

...

Keyword(s):

Intensive Care Unit ◽

Acute Kidney Injury ◽

Intensive Care ◽

Kidney Transplant ◽

Meta Analysis ◽

Graft Loss ◽

Kidney Injury ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Kidney Replacement Therapy

The adverse impact of Coronavirus disease 2019 (COVID-19) on kidney function has been reported since the global pandemic. The burden of COVID-19 on kidney transplant recipients, however, has not been systematically analyzed. A systematic review and meta-analysis with a random-effect model was conducted to explore the rate of mortality, intensive care unit admission, invasive mechanical ventilation, acute kidney injury, kidney replacement therapy and graft loss in the adult kidney transplant population with COVID-19. Sensitivity analysis, subgroup analysis and meta-regression were also performed. Results: we demonstrated a pooled mortality rate of 21% (95% CI: 19−23%), an intensive care unit admission rate of 26% (95% CI: 22–31%), an invasive ventilation rate among those who required intensive care unit care of 72% (95% CI: 62–81%), an acute kidney injury rate of 44% (95% CI: 39–49%), a kidney replacement therapy rate of 12% (95% CI: 9–15%), and a graft loss rate of 8% (95% CI: 5–15%) in kidney transplant recipients with COVID-19. The meta-regression indicated that advancing age is associated with higher mortality; every increase in age by 10 years was associated with an increased mortality rate of 3.7%. Regional differences in outcome were also detected. Further studies focused on treatments and risk factor identification are needed.

Download Full-text