Recent Developments in Haploidentical Stem Cell Transplantation: Therapy and Complications

Ischemic heart disease and myocardial infarction remain leading causes of mortality worldwide. Existing myocardial infarction treatments are incapable of fully repairing and regenerating the infarcted myocardium. Stem cell transplantation therapy has demonstrated promising results in improving heart function following myocardial infarction. However, poor cell survival and low engraftment at the harsh and hostile environment at the site of infarction limit the regeneration potential of stem cells. Preconditioning with various physical and chemical factors, as well as genetic modification and cellular reprogramming, are strategies that could potentially optimize stem cell transplantation therapy for clinical application. In this review, we discuss the most up-to-date findings related to utilizing preconditioned stem cells for myocardial infarction treatment, focusing mainly on preconditioning with hypoxia, growth factors, drugs, and biological agents. Furthermore, genetic manipulations on stem cells, such as the overexpression of specific proteins, regulation of microRNAs, and cellular reprogramming to improve their efficiency in myocardial infarction treatment, are discussed as well.

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Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

Progress in Neurobiology ◽

10.1016/j.pneurobio.2017.03.003 ◽

2017 ◽

Vol 157 ◽

pp. 49-78 ◽

Cited By ~ 52

Author(s):

Ling Wei ◽

Zheng Z. Wei ◽

Michael Qize Jiang ◽

Osama Mohamad ◽

Shan Ping Yu

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Therapeutic Benefits ◽

Cell Transplantation Therapy ◽

Transplantation Therapy

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Combining transfusion of stem/progenitor cells into the peripheral circulation with localized transplantation in situ at the site of tissue/organ damage: A possible strategy to optimize the efficacy of stem cell transplantation therapy

Medical Hypotheses ◽

10.1016/j.mehy.2005.04.003 ◽

2005 ◽

Vol 65 (3) ◽

pp. 494-497 ◽

Cited By ~ 2

Author(s):

Boon Chin Heng ◽

Husnain Khawaja Haider ◽

Tong Cao

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Progenitor Cells ◽

Cell Transplantation ◽

Peripheral Circulation ◽

Organ Damage ◽

Cell Transplantation Therapy ◽

Transplantation Therapy

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Current Status and Future Development of Cell Transplantation Therapy for Periodontal Tissue Regeneration

International Journal of Dentistry ◽

10.1155/2012/307024 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 38

Author(s):

Toshiyuki Yoshida ◽

Kaoru Washio ◽

Takanori Iwata ◽

Teruo Okano ◽

Isao Ishikawa

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

New Technology ◽

Basic Research ◽

Current Status ◽

Periodontal Tissue ◽

Research Risks ◽

Cell Transplantation Therapy ◽

Transplantation Therapy

It has been shown that stem cell transplantation can regenerate periodontal tissue, and several clinical trials involving transplantation of stem cells into human patients have already begun or are in preparation. However, stem cell transplantation therapy is a new technology, and the events following transplantation are poorly understood. Several studies have reported side effects and potential risks associated with stem cell transplantation therapy. To protect patients from such risks, governments have placed regulations on stem cell transplantation therapies. It is important for the clinicians to understand the relevant risks and governmental regulations. This paper describes the ongoing clinical studies, basic research, risks, and governmental controls related to stem cell transplantation therapy. Then, one clinical study is introduced as an example of a government-approved periodontal cell transplantation therapy.

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