Targeting Developmental Pathways in Inflammation and Disease

2022 ◽  
2019 ◽  
Author(s):  
Fatima Valdes-Mora ◽  
Robert Salomon ◽  
Brian Gloss ◽  
Andrew MK Law ◽  
Kendelle Murphy ◽  
...  

Author(s):  
Andrea M. Hussong ◽  
W. Andrew Rothenberg ◽  
Ruth K Smith ◽  
Maleeha Haroon

This chapter discusses current conceptualizations of heterogeneity in alcohol use disorder (AUD), characterizes developmental pathways that lead to different subtypes of AUDs, and discusses how such pathways can inform preventive program design. Specifically, it reviews the “internalizing” and “externalizing” developmental pathways to AUDs. The externalizing pathway is characterized by a core deficit in behavioral control, whereas the internalizing pathway is characterized by a core deficit in emotion regulation. Both pathways predict drinking onset and escalation to AUD for some individuals. The chapter calls for the development of interventions to treat early childhood precursors to AUDs, innovative methods to identify individuals at risk for early emerging AUDs, additional investigation of how core pathway deficits operate across development, and greater consideration of how externalizing and internalizing pathways may interact within and across individuals.


Author(s):  
Lene Arnett Jensen

This chapter introduces The Oxford Handbook of Moral Development: An Interdisciplinary Perspective. The handbook provides a comprehensive, international, and up-to-date review of research on moral development, including moral motives and behaviors, ontogeny and developmental pathways, and contexts that children, adolescents, and adults experience with respect to morality. Across more than 40 chapters, experts from disciplines such as anthropology, education, human development, psychology, and sociology address moral development through the entire life course among diverse groups within and across countries. This chapter addresses how the chapters provide literature reviews that are inclusive of highly diverse theoretical and research foci, as well as of diverse cultural, socioeconomic, and gender groups. The aim of the handbook is to contribute to the revitalization and flourishing of the field of moral development.


Author(s):  
Gabriele Skabeikyte ◽  
Rasa Barkauskiene

Abstract Background Research on personality pathology in adolescence has accelerated during the last decade. Among all of the personality disorders, there is strong support for the validity of borderline personality disorder (BPD) diagnosis in adolescence with comparable stability as seen in adulthood. Researchers have put much effort in the analysis of the developmental pathways and etiology of the disorder and currently are relocating their attention to the identification of the possible risk factors associated with the course of BPD symptoms during adolescence. The risk profile provided in previous systematic reviews did not address the possible development and course of BPD features across time. Having this in mind, the purpose of this systematic review is to identify the factors that are associated with the course of BPD symptoms during adolescence. Methods Electronic databases were systematically searched for prospective longitudinal studies with at least two assessments of BPD as an outcome of the examined risk factors. A total number of 14 articles from the period of almost 40 years were identified as fitting the eligibility criteria. Conclusions Factors associated with the course of BPD symptoms include childhood temperament, comorbid psychopathology, and current interpersonal experiences. The current review adds up to the knowledge base about factors that are associated with the persistence or worsening of BPD symptoms in adolescence, describing the factors congruent to different developmental periods.


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