Preparation, characterization, and in vitro bioactivity of Mg-containing biphasic calcium phosphate bioceramics

In the present study, an Intelligent Multi-parameter Simulated Evaluation in vitro （IMSE system） was used to study the deposition properties of apatite formation on the surface of biphasic calcium phosphate porous ceramic (BCP) from static and dynamic r-SBF. Results showed that apatite formed on the surface of BCP from static and dynamic r-SBF differed between each other. In static r-SBF, ions were transferred by diffusion, which could not compensate the consuming of calcium ions, and mist apatite layer was formed on the surface of samples. But in the dynamic r-SBF, simulated fluid was adjusted precisely and flowed forcedly, the concentrations of ions were homogeneous; with the compensation of ions, calcium and phosphate were supersaturated, and the free energy of apatite formation was negative, bone-like apatite sheets were formed on the surface of samples.

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Organic/Inorganic bioactive materials Part III: in vitro bioactivity of gelatin/silicocarnotite hybrids

Open Chemistry ◽

10.2478/s11532-009-0078-z ◽

2009 ◽

Vol 7 (4) ◽

pp. 721-730 ◽

Cited By ~ 1

Author(s):

Lachezar Radev ◽

Maria Fernandes ◽

Isabel Salvado ◽

Daniela Kovacheva

Keyword(s):

Calcium Phosphate ◽

Hybrid Materials ◽

Calcium Phosphates ◽

Ceramic Powder ◽

Structure Evolution ◽

In Vitro Test ◽

In Vitro Bioactivity ◽

Bioactive Materials ◽

Vitro Test

AbstractIn this work we present our experimental results on synthesis, structure evolution and in vitro bioactivity assessment of new gelatin/silicocarnotite hybrid materials. The hybrids were obtained by diluting gelatin (G) and silicocarnotite (S) ceramic powder with G:S ratios of 75:25 and 25:75 wt.% in hot (40°C) water. The hybrids were characterized using XRD, FTIR, SEM/EDS and XPS. FTIR depicts that the “red shift” of amide I and COO− could be attributed to the fact that the gelatin prefers to chelate Ca2+ from S. The growth of calcium phosphates on the surface of the hybrids synthesized and then immersed in 1.5 SBF for 3 days was studied by using of FTIR, XRD and SEM/EDS. According to FTIR results, after an immersion of 3 days, A and B-type CO3HA can be observed on the surface. XRD results indicate the presence of hydroxyapatite with well defined crystallinity. SEM/EDS of the precipitated layers show the presence of CO3HA and amorphous calcium phosphate on the surface of samples with different G/S content when immersed in 1.5 SBF. XPS of the G/S hybrid with 25:75 wt.% proved the presence of Ca-deficient hydroxyapatite after an in vitro test for 3 days.

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Biocompatibility of Surface-Modified Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite in vitro and in vivo

Journal of Material Science and Technology ◽

10.1016/s1005-0302(10)60119-3 ◽

2010 ◽

Vol 26 (8) ◽

pp. 754-758 ◽

Cited By ~ 8

Author(s):

Weizhong Yang ◽

Guangfu Yin ◽

Dali Zhou ◽

Jianwen Gu ◽

Yadong Li ◽

...

Keyword(s):

Calcium Phosphate ◽

Biphasic Calcium Phosphate ◽

Surface Modified

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In vitro evaluation of an injectable biphasic calcium phosphate (BCP) carrier system combined with recombinant human bone morphogenetic protein (rhBMP)-9

Bio-Medical Materials and Engineering ◽

10.3233/bme-171675 ◽

2017 ◽

Vol 28 (3) ◽

pp. 293-304 ◽

Cited By ~ 2

Author(s):

Masako Fujioka-Kobayashi ◽

Benoit Schaller ◽

Yufeng Zhang ◽

Benjamin E. Pippenger ◽

Richard J. Miron

Keyword(s):

Calcium Phosphate ◽

Bone Morphogenetic Protein ◽

Biphasic Calcium Phosphate ◽

Human Bone ◽

Carrier System ◽

In Vitro Evaluation ◽

Morphogenetic Protein ◽

Human Bone Morphogenetic Protein ◽

Recombinant Human Bone

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Development of injectable chitosan/biphasic calcium phosphate bone cement and in vitro and in vivo evaluation

Biomedical Materials ◽

10.1088/1748-605x/ab8441 ◽

2020 ◽

Vol 15 (5) ◽

pp. 055038

Author(s):

Sirirat T. Rattanachan ◽

Nuan La-ong Srakaew ◽

Paritat Thaitalay ◽

Oranich Thongsri ◽

Rawee Dangviriyakul ◽

...

Keyword(s):

Calcium Phosphate ◽

Bone Cement ◽

Biphasic Calcium Phosphate ◽

In Vivo Evaluation ◽

Calcium Phosphate Bone Cement

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Composite Bioceramics/Polymer Electrospun Scaffolds for Regenerative Medicine

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.529-530.441 ◽

2012 ◽

Vol 529-530 ◽

pp. 441-446

Author(s):

Thomas Miramond ◽

Pascal Borget ◽

Caroline Colombeix ◽

Serge Baroth ◽

G. Daculsi

Keyword(s):

Cell Adhesion ◽

Calcium Phosphate ◽

Regenerative Medicine ◽

Tricalcium Phosphate ◽

Biphasic Calcium Phosphate ◽

Electrospun Scaffolds ◽

Mineral Particles

The main goal of this study was to succeed in the relevant association of well-known osteoconductive biphasic calcium phosphate (BCP) made of Hydroxyapatite (20% HA) and β-Tricalcium Phosphate (80% β-TCP) crystallographic phases and resorbable poly (L-lactide-co-D,L-lactide)(PLDLLA) 3D matrices synthesized by electrospinning. Two types of mineral particles were obtained, BCP new hollow granules, and classical BCP particles. It appeared that hollow shells/PLDLLA composite 3D matrices allowed higher cell adhesionin vitro,thanks to internal concavities and are promising scaffolds in terms of cell carrying.

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