scholarly journals Applications of Bioadhesives: A Mini Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Wanglin Duan ◽  
Xiangbing Bian ◽  
Yazhong Bu
Keyword(s):  
Medical Device ◽  
Wound Dressing ◽  
Wound Closure ◽  
Clinical Applications ◽  
Research Articles ◽  
Tissue Adhesives ◽  
Delivery Vehicles

Bioadhesives have demonstrated their superiority in clinical applications as tissue adhesives, hemostats, and tissue sealants. Because of the intrinsic stickiness, the applications have been expanded to various areas, such as functional wound dressing, factor delivery vehicles, and even medical device fixation. While many literature works discussed the mechanism of bioadhesives, few of them specifically summarized the applications of bioadhesives. To fill in the blanks, this review covers recent research articles and focuses precisely on the applications of bioadhesives which can be generally classified as follows: 1) wound closure, 2) sealing leakage, and 3) immobilization, including those already in the clinic and those showing great potential in the clinic. It is expected that this article will provide a whole picture on bioadhesives’ applications and lead to innovations in the application of bioadhesives in new fields.

scholarly journals A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shanshan Hu ◽  
Xibo Pei ◽  
Lunliang Duan ◽  
Zhou Zhu ◽  
Yanhua Liu ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Wound Closure ◽  
Ex Vivo ◽  
Covalent Bonding ◽  
Mucosal Barrier ◽  
Buccal Delivery ◽  
Tissue Adhesives ◽  
Drug Bioavailability ◽  
Buccal Drug Delivery ◽  
Strong Adhesion

AbstractAdministration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.

scholarly journals Guest Editorial: Multimedia Medical Device (MMD) Designing and Clinical Applications

2016 ◽  
Vol 75 (22) ◽  
pp. 14197-14201
Author(s):  
Jiachen Yang ◽  
Zhihan Lv ◽  
Tengfei Yin
Keyword(s):  
Medical Device ◽  
Guest Editorial ◽  
Clinical Applications

scholarly journals Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Farhad Abasalizadeh ◽  
Sevil Vaghefi Moghaddam ◽  
Effat Alizadeh ◽  
Elahe akbari ◽  
Elmira Kashani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Wound Dressing ◽  
3D Bioprinting ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Héctor Capella-Monsonís ◽  
Andrea De Pieri ◽  
Rita Peixoto ◽  
Stefanie Korntner ◽  
Dimitrios I. Zeugolis
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Wound Dressing ◽  
Collagen Scaffold ◽  
Cell Delivery ◽  
Adipose Derived Stem Cells ◽  
Stem Cell Delivery ◽  
Delivery Vehicles ◽  
Tissue Grafts ◽  
Adipose Derived Stem Cell

Abstract Background Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. scaffolds and tissue grafts), due to their compositional biofunctionality and cytocompatibility, are under investigation as potential stem cell carriers. Methods The present study assessed the potential of three commercially available extracellular matrix-based biomaterials [a collagen/glycosaminoglycan scaffold (Integra™ Matrix Wound Dressing), a decellularised porcine peritoneum (XenoMEM™) and a porcine urinary bladder (MatriStem™)] as human adipose-derived stem cell delivery vehicles. Results Both tissue grafts induced significantly (p < 0.01) higher human adipose-derived stem cell proliferation in vitro over the collagen scaffold, especially when the cells were seeded on the basement membrane side. Human adipose-derived stem cell phenotype and trilineage differentiation potential was preserved in all biomaterials. In a splinted wound healing nude mouse model, in comparison to sham, biomaterials alone and cells alone groups, all biomaterials seeded with human adipose-derived stem cells showed a moderate improvement of wound closure, a significantly (p < 0.05) lower wound gap and scar index and a significantly (p < 0.05) higher proportion of mature collagen deposition and angiogenesis (the highest, p < 0.01, was observed for the cell loaded at the basement membrane XenoMEM™ group). All cell-loaded biomaterial groups retained more cells at the implantation side than the direct injection group, even though they were loaded with half of the cells than the cell injection group. Conclusions This study further advocates the use of extracellular matrix-based biomaterials (in particular porcine peritoneum) as human adipose-derived stem cell delivery vehicles. Graphical abstract Comparative analysis of a collagen scaffold (Integra™ Matrix Wound Dressing) and two tissue grafts [decellularised porcine peritoneum (XenoMEM™) and porcine urinary bladder (MatriStem™)] as human adipose-derived stem cells carriers

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