Reactivation of Atrium Genes Is a Primer for Heart Infarction or Regeneration

From June 1975 to August 1977, 19 patients with distant metastases of malignant melanoma of the skin that were no longer responsive to chemotherapy were treated with BCG given intravenously. A single dose of lyophilized Pasteur BCG ranging from 2×107 to to 3×108 viable units was given in 500 ml of saline infused in 5 to 6 h. Seven of the 16 evaluable patients benefited from treatment; 3 showed an objective regression of more than 50% of the original tumor volume, and 4 an arrest of tumor growth. The objective regressions lasted from 2 to 5 months, and 1 case had an arrest of tumor growth for 29 months. The regression rate was related to the BCG dosage: 2×108 viable units appears to be the dosage that gives severe but reversible toxicity and is able to induce objective regression. The most responsive lesions were skin and subcutaneous deposits (5 of 7) and lung metastases (1 of 4). Toxic effects seem to be related to the number of bacilli injected. In the group of 10 cases treated with less than 108 units, toxicity was modest: 4 patients had fever (up to 38.5 °C) that lasted a few days, and in 3 cases it was associated with shivering during the infusion period and weakness. One case only had vomiting and jaundice. Toxicity was severe in the 9 patients that were treated with a dosage higher than 108: patients had fever and weakness for at least 4 days and shivering during the infusion. Two had adrenal insufficiency and 7 had liver enlargement and jaundice with return to normality by day 21. In the whole series 8 patients had leucopenia and 5 thrombocytopenia for 2 to 3 days: only 1 patient required blood and platelet transfusion. No significant variations in immunoglobulin levels were observed. No variations of PPD or BCG skin tests were observed after treatment. Three patients expired; the first, treated with 6×107 units, had an intercurrent disease (autopsy showed a heart infarction); the second, treated with 1.8×108, showed a rapid growth of lung metastases and died 15 days after treatment; the death of the third patient was probably due to anaphylactic shock. All 3 patients had been previously treated with BCG, given by scarification or intranodular injection.

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The Prognostic Significance of Exercise Induced Hypertension in Heart Infarction Patients

Biological and Psychological Factors in Cardiovascular Disease ◽

10.1007/978-3-642-71234-0_27 ◽

1986 ◽

pp. 447-455 ◽

Cited By ~ 1

Author(s):

A.-T. Tammen ◽

G. Bierck ◽

T. Fentrop ◽

G. Blümchen

Keyword(s):

Prognostic Significance ◽

Heart Infarction ◽

Induced Hypertension ◽

Exercise Induced

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Sensing a heart infarction marker with surface plasmon resonance spectroscopy

10.1117/12.201250 ◽

1995 ◽

Cited By ~ 3

Author(s):

Ulrich Kunz ◽

Andreas Katerkamp ◽

Reinhard Renneberg ◽

Friedrich Spener ◽

Karl Cammann

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Resonance Spectroscopy ◽

Surface Plasmon Resonance Spectroscopy ◽

Heart Infarction

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Dental Calculus Is Associated with Death from Heart Infarction

BioMed Research International ◽

10.1155/2014/569675 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Birgitta Söder ◽

Jukka H. Meurman ◽

Per-Östen Söder

Keyword(s):

Cardiac Death ◽

International Classification Of Diseases ◽

Dental Calculus ◽

Chi Square ◽

Heart Infarction ◽

Classification Of Diseases ◽

The Difference ◽

The Relationship

Objectives. We studied whether the amount of dental calculus is associated with death from heart infarction in the dental infection—atherosclerosis paradigm.Materials. Participants were 1676 healthy young Swedes followed up from 1985 to 2011. At the beginning of the study all subjects underwent oral clinical examination including dental calculus registration scored with calculus index (CI). Outcome measure was cause of death classified according to WHO International Classification of Diseases. Unpairedt-test, Chi-square tests, and multiple logistic regressions were used.Results. Of the 1676 participants, 2.8% had died during follow-up. Women died at a mean age of 61.5 years and men at 61.7 years. The difference in the CI index score between the survivors versus deceased patients was significant by the year 2009 (P<0.01). In multiple regression analysis of the relationship between death from heart infarction as a dependent variable and CI as independent variable with controlling for age, gender, dental visits, dental plaque, periodontal pockets, education, income, socioeconomic status, and pack-years of smoking, CI score appeared to be associated with 2.3 times the odds ratio for cardiac death.Conclusions. The results confirmed our study hypothesis by showing that dental calculus indeed associated statistically with cardiac death due to infarction.

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