scholarly journals Angiotensin II Modulates Podocyte Glucose Transport

2018 ◽  
Vol 9 ◽  
Author(s):  
Barbara Lewko ◽  
Anna Maryn ◽  
Elzbieta Latawiec ◽  
Agnieszka Daca ◽  
Apolonia Rybczynska
Keyword(s):  
Angiotensin Ii ◽  
Glucose Transport

scholarly journals Rosmarinic acid improves hypertension and skeletal muscle glucose transport in angiotensin II-treated rats

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Mujalin Prasannarong ◽  
Vitoon Saengsirisuwan ◽  
Juthamard Surapongchai ◽  
Jariya Buniam ◽  
Natsasi Chukijrungroat ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Angiotensin Ii ◽  
Glucose Transport ◽  
Rosmarinic Acid ◽  
Muscle Glucose Transport

Selective angiotensin II receptor antagonism enhances whole-body insulin sensitivity and muscle glucose transport in hypertensive TG(mREN2)27 rats

Metabolism ◽  
2005 ◽  
Vol 54 (12) ◽  
pp. 1659-1668 ◽  
Author(s):  
Julie A. Sloniger ◽  
Vitoon Saengsirisuwan ◽  
Cody J. Diehl ◽  
John S. Kim ◽  
Erik J. Henriksen
Keyword(s):  
Insulin Sensitivity ◽  
Angiotensin Ii ◽  
Glucose Transport ◽  
Whole Body ◽  
Angiotensin Ii Receptor ◽  
Receptor Antagonism ◽  
Muscle Glucose Transport

Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat

2005 ◽  
Vol 288 (6) ◽  
pp. E1074-E1081 ◽  
Author(s):  
Julie A. Sloniger ◽  
Vitoon Saengsirisuwan ◽  
Cody J. Diehl ◽  
Betsy B. Dokken ◽  
Narissara Lailerd ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Angiotensin Ii ◽  
Insulin Receptor ◽  
Signaling Pathway ◽  
Glucose Transport ◽  
Insulin Signaling ◽  
Glycogen Synthase ◽  
Insulin Signaling Pathway ◽  
Whole Body

Essential hypertension is frequently associated with insulin resistance of skeletal muscle glucose transport, with a potential role of angiotensin II in the pathogenesis of both conditions. The male heterozygous TG(mREN2)27 rat harbors the mouse transgene for renin, exhibits local elevations in angiotensin II, and is an excellent model of both hypertension and insulin resistance. The present study was designed to investigate the potential cellular mechanisms for insulin resistance in this hypertensive animal model, including an assessment of elements of the insulin-signaling pathway. Compared with nontransgenic, normotensive Sprague-Dawley control rats, male heterozygous TG(mREN2)27 rats displayed elevated ( P < 0.05) fasting plasma insulin (74%), an exaggerated insulin response (108%) during an oral glucose tolerance test, and reduced whole body insulin sensitivity. TG(mREN2)27 rats also exhibited decreased insulin-mediated glucose transport and glycogen synthase activation in both the type IIb epitrochlearis (30 and 46%) and type I soleus (22 and 64%) muscles. Importantly, there were significant reductions (∼30–50%) in insulin stimulation of tyrosine phosphorylation of the insulin receptor β-subunit and insulin receptor substrate-1 (IRS-1), IRS-1 associated with the p85 subunit of phosphatidylinositol 3-kinase, Akt Ser473 phosphorylation, and Ser9 phosphorylation of glycogen synthase kinase-3β in epitrochlearis and soleus muscles of TG(mREN2)27 rats. Soleus muscle triglyceride concentration was 25% greater in the transgenic group compared with nontransgenic animals. Collectively, these data provide the first evidence that the insulin resistance of the hypertensive male heterozygous TG(mREN2)27 rat can be attributed to specific defects in the insulin-signaling pathway in skeletal muscle.

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