scholarly journals miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Xingyu Chang ◽  
Guomao Zhu ◽  
Zongyan Cai ◽  
Yaqi Wang ◽  
Rongna Lian ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Noncoding Rna ◽  
Retinal Pigment ◽  
Regulation Of Gene Expression ◽  
Diabetic Complication ◽  
Retinal Pigment Epithelial Cells ◽  
Underlying Mechanisms ◽  
Pigment Epithelial Cells

Diabetic retinopathy (DR) is a common diabetic complication and the main cause of blindness worldwide, which seriously affects the quality of life of patients. Studies have shown that noncoding RNA (ncRNA) has distinct differentiated expression in DR and plays an important role in the occurrence and development of DR. ncRNAs represented by microRNAs (miRNAs), lncRNAs (lncRNAs), and circRNAs (circRNAs) have been shown to be widely involved in the regulation of gene expression and affect multiple biological processes of retinopathy. This article will review three RNAs related to the occurrence and development of DR on the basis of previous studies (especially their effects on retinal microangiopathy, retinal pigment epithelial cells, and retinal nerve cells) and discuss their underlying mechanisms and connections. Overall, this review will help us better understand the role of ncRNAs in the occurrence and development of DR and provide ideas for exploring potential therapeutic directions and targets.

scholarly journals MiR-542-5p regulates the progression of diabetic retinopathy by targeting CARM1

2020 ◽  
Author(s):  
Ning Guo ◽  
Ayinu Nulahou ◽  
Qian Bu ◽  
Meng Liu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Vision Loss ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Arginine Methyltransferase ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells

Diabetic retinopathy (DR), as the most frequent microvascular complication of diabetes mellitus (DM), causes vision loss and blindness in adults worldwide with increasing incidence. MicroRNAs (miRNAs) are involved in the regulation of DR. However, the role of miR-542-5p is still unknown. Here, we demonstrate that miR-542-5p is down-regulated in patients with DR and in high-glucose (HG)-treated retinal pigment epithelial cells. Moreover, miR-542-5p overexpression inhibits apoptosis in retinal pigment epithelial cells exposed to HG. The interaction between miR-542-5p and co-activator-associated arginine methyltransferase 1 (CARM1) is confirmed. MiR-542-5p mimics decrease the CARM1 level and miR-542-5p inhibitor increases the CARM1 level. Additionally, CARM1 overexpression promotes the miR-542-5p-mediated apoptosis in HG-treated retinal pigment epithelial cells. In summary, the data suggest that miR-542-5p may suppress apoptosis in retinal pigment epithelial cells via targeting CARM1, which provides a new therapeutic target for the treatment of patients with DR.

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