scholarly journals Development and Application of High-Content Biological Screening for Modulators of NET Production

2018 ◽  
Vol 9 ◽  
Author(s):  
Ilaria J. Chicca ◽  
Michael R. Milward ◽  
Iain Leslie C. Chapple ◽  
Gareth Griffiths ◽  
Rod Benson ◽  
...  
2019 ◽  
Vol 19 (16) ◽  
pp. 1292-1297 ◽  
Author(s):  
Ali Mohd Ganie ◽  
Ayaz Mahmood Dar ◽  
Fairooz Ahmad Khan ◽  
Bashir Ahmad Dar

:Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines.


2021 ◽  
Vol 332 ◽  
pp. 115844
Author(s):  
Seraj Omar Alzahrani ◽  
Ahmed M. Abu-Dief ◽  
Kholood Alkhamis ◽  
Fatmah Alkhatib ◽  
Tarek El-Dabea ◽  
...  

ChemInform ◽  
2010 ◽  
Vol 25 (11) ◽  
pp. no-no
Author(s):  
S. MUNAVALLI ◽  
D. I. ROSSMAN ◽  
D. K. ROHRBAUGH ◽  
C. P. FERGUSON ◽  
L. BUETTNER
Keyword(s):  

1982 ◽  
Vol 95 (4) ◽  
pp. 359-373 ◽  
Author(s):  
Makoto Kimura ◽  
Masaki Funakoshi ◽  
Shinpei Sudo ◽  
Takehiro Masuzawa ◽  
Toshie Nakamura ◽  
...  

1978 ◽  
Vol 56 (12) ◽  
pp. 1425-1433 ◽  
Author(s):  
Robert E. Moeller

The evergreen characteristic of Lobelia dortmanna L. involves biomass and nutrient conservation. Although 60% of the maximum, midsummer biomass overwinters, little or no new tissue is produced between October and early May. Annual net production, estimated from the rate of leaf turnover, is less than the maximum biomass (P/B = 0.69 per year). Nitrogen and P concentrations are lowest in mid-August, when the amount of each analyzed element per square metre is near its maximum (N, P, Ca, Mg, Na, K). Autumnal uptake of N may contribute 25% of the next season's growth requirements, but P uptake is largely offset by losses during the winter. Fruiting and sterile plants have similar contents of N, P, and K in late July, but the fruiting plants are richer in Ca, Mg, Na, Fe, Mn, and Zn. At the maximum depth limit of the population in Mirror Lake, New Hampshire (2.3 m), flowering is absent and seedlings are sparse, suggesting reproductive failure as a controlling factor at the margin of the population.


2003 ◽  
Vol 69 (2) ◽  
pp. 787-795 ◽  
Author(s):  
Rainer Kurmayer ◽  
Guntram Christiansen ◽  
Ingrid Chorus

ABSTRACT The working hypotheses tested on a natural population of Microcystis sp. in Lake Wannsee (Berlin, Germany) were that (i) the varying abundance of microcystin-producing genotypes versus non-microcystin-producing genotypes is a key factor for microcystin net production and (ii) the occurrence of a gene for microcystin net production is related to colony morphology, particularly colony size. To test these hypotheses, samples were fractionated by colony size with a sieving procedure during the summer of 2000. Each colony size class was analyzed for cell numbers, the proportion of microcystin-producing genotypes, and microcystin concentrations. The smallest size class of Microcystis colonies (<50 μm) showed the lowest proportion of microcystin-producing genotypes, the highest proportion of non-microcystin-producing cells, and the lowest microcystin cell quotas (sum of microcystins RR, YR, LR, and WR). In contrast, the larger size classes of Microcystis colonies (>100 μm) showed the highest proportion of microcystin-producing genotypes, the lowest proportion of non-microcystin-producing cells, and the highest microcystin cell quotas. The microcystin net production rate was nearly one to one positively related to the population growth rate for the larger colony size classes (>100 μm); however, no relationship could be found for the smaller size classes. It was concluded that the variations found in microcystin net production between colony size classes are chiefly due to differences in genotype composition and that the microcystin net production in the lake is mainly influenced by the abundance of the larger (>100-μm) microcystin-producing colonies.


1971 ◽  
Vol 1 (4) ◽  
pp. 262-266 ◽  
Author(s):  
D. F. W. Pollard

Biomass (stems and branches) increased from 17 000 kg h−1 in the 4th year to 34 000 kg h−1 in the 7th year of development of an aspen sucker stand. The bulk of the biomass was distributed in the middle and upper diameter classes of shoots; net annual increases only occurred in the upper classes. About 80% of shoots dying in the 3 years of study were less than 2 cm dbh; the biomass lost in these amounted to 200 kg h−1 or less each year. The remaining 20% mortality occurred in the 7th year among shoots 2–5 cm dbh infected with Diplodiatumefaciens. Biomass lost in these larger shoots amounted to 4 900 kg h−1; this was close to the discrepancy between net production (stems and branches) in the 7th year (2600 kg h−1 per annum) and net production in the 5th and 6th years (about 7000 kg h−1 per annum.) Results suggest that although high rates of net annual production are obtainable in short rotations, the mean annual production is strongly influenced by disease because of insufficient time for enhanced growth of survivors.


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