scholarly journals Acquisition of N-Glycosylation Sites in Immunoglobulin Heavy Chain Genes During Local Expansion in Parotid Salivary Glands of Primary Sjögren Patients

2018 ◽  
Vol 9 ◽  
Author(s):  
Annie Visser ◽  
Marieke E. Doorenspleet ◽  
Niek de Vries ◽  
Fred K. L. Spijkervet ◽  
Arjan Vissink ◽  
...  
Blood ◽  
2001 ◽  
Vol 98 (7) ◽  
pp. 2272-2274 ◽  
Author(s):  
Karin Fasching ◽  
Simon Panzer ◽  
Oskar A. Haas ◽  
Arndt Borkhardt ◽  
Rolf Marschalek ◽  
...  

Childhood acute lymphoblastic leukemia (ALL) is frequently initiated in utero at a time of developmentally regulated insertion of N regions into the DJH rearrangements of immunoglobulin heavy-chain (IgH) genes. Here it is shown that N regions are present in the clonotypic DJH rearrangements in 11 of 12 infant ALLs with t(4;11). These data are compared with the 122 previously published DJH sequences and were found to have a pattern similar to that of ALL in children older than 3 years at diagnosis but were unlike that in children younger than 3 years who predominantly lack N regions. These findings, therefore, indicate that t(4;11)-positive infant ALL is initiated later in fetal development than most B-cell precursor ALL from children younger than 3 years and that they have a shorter latency period already in utero.


2004 ◽  
Vol 203 (3) ◽  
pp. 155-164 ◽  
Author(s):  
Atsushi Hoshino ◽  
Tadao Funato ◽  
Yasuhiko Munakata ◽  
Tomonori Ishii ◽  
Shori Abe ◽  
...  

1997 ◽  
Vol 18 (11) ◽  
pp. 543-549 ◽  
Author(s):  
Samuel F. Schluter ◽  
Ralph M. Bernstein ◽  
John J. Marchalonis

Nature ◽  
1981 ◽  
Vol 290 (5807) ◽  
pp. 562-565 ◽  
Author(s):  
Hitoshi Sakano ◽  
Yoshikazu Kurosawa ◽  
Martin Weigert ◽  
Susumu Tonegawa

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