scholarly journals Multiple Origins of Extracellular DNA Traps

2021 ◽  
Vol 12 ◽  
Author(s):  
Edgar Ramos-Martínez ◽  
Leticia Hernández-González ◽  
Iván Ramos-Martínez ◽  
Laura Pérez-Campos Mayoral ◽  
Georgina I. López-Cortés ◽  
...  
Keyword(s):  
Extracellular Dna ◽  
Multiple Origins ◽  
Evolutionarily Conserved ◽  
Evolutionary Convergence ◽  
Multicellular Organisms ◽  
Extracellular Dna Traps

Extracellular DNA traps (ETs) are evolutionarily conserved antimicrobial mechanisms present in protozoa, plants, and animals. In this review, we compare their similarities in species of different taxa, and put forward the hypothesis that ETs have multiple origins. Our results are consistent with a process of evolutionary convergence in multicellular organisms through the application of a congruency test. Furthermore, we discuss why multicellularity is related to the presence of a mechanism initiating the formation of ETs.

Apoptosis and development

2003 ◽  
Vol 39 ◽  
pp. 11-24 ◽  
Author(s):  
Justin V McCarthy
Keyword(s):  
Drosophila Melanogaster ◽  
Mammalian Cells ◽  
Cell Number ◽  
Model Organisms ◽  
Biological Processes ◽  
Nematode Caenorhabditis Elegans ◽  
Apoptotic Pathway ◽  
Genetic Pathways ◽  
Evolutionarily Conserved ◽  
Multicellular Organisms

Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The large diversity of regulators of apoptosis in mammalian cells and their numerous interactions complicate the analysis of their individual functions, particularly in development. The remarkable conservation of apoptotic mechanisms across species has allowed the genetic pathways of apoptosis determined in lower species, such as the nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster, to act as models for understanding the biology of apoptosis in mammalian cells. Though many components of the apoptotic pathway are conserved between species, the use of additional model organisms has revealed several important differences and supports the use of model organisms in deciphering complex biological processes such as apoptosis.

Detection of Eosinophil Extracellular DNA Traps

2021 ◽  
pp. 193-198
Author(s):  
Marina Valente Barroso ◽  
Josiane Sabbadini Neves
Keyword(s):  
Extracellular Dna ◽  
Extracellular Dna Traps

scholarly journals The many roads to and from multicellularity

2019 ◽  
Vol 71 (11) ◽  
pp. 3247-3253 ◽  
Author(s):  
Karl J Niklas ◽  
Stuart A Newman
Keyword(s):  
Common Ancestor ◽  
Cell Attachment ◽  
Terrestrial Ecosystems ◽  
Life Forms ◽  
Last Common Ancestor ◽  
Physiological Mechanisms ◽  
Multiple Origins ◽  
Recent Developments ◽  
The Many ◽  
Multicellular Organisms

Abstract The multiple origins of multicellularity had far-reaching consequences ranging from the appearance of phenotypically complex life-forms to their effects on Earth’s aquatic and terrestrial ecosystems. Yet, many important questions remain. For example, do all lineages and clades share an ancestral developmental predisposition for multicellularity emerging from genomic and biophysical motifs shared from a last common ancestor, or are the multiple origins of multicellularity truly independent evolutionary events? In this review, we highlight recent developments and pitfalls in understanding the evolution of multicellularity with an emphasis on plants (here defined broadly to include the polyphyletic algae), but also draw upon insights from animals and their holozoan relatives, fungi and amoebozoans. Based on our review, we conclude that the evolution of multicellular organisms requires three phases (origination by disparate cell–cell attachment modalities, followed by integration by lineage-specific physiological mechanisms, and autonomization by natural selection) that have been achieved differently in different lineages.

scholarly journals NADPH Oxidase–Independent Formation of Extracellular DNA Traps by Basophils

2014 ◽  
Vol 192 (11) ◽  
pp. 5314-5323 ◽  
Author(s):  
Mahbubul Morshed ◽  
Ruslan Hlushchuk ◽  
Dagmar Simon ◽  
Andrew F. Walls ◽  
Kazushige Obata-Ninomiya ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Extracellular Dna ◽  
Extracellular Dna Traps

Extracellular DNA traps in bronchoalveolar fluid from a murine eosinophilic pulmonary response

Allergy ◽  
2014 ◽  
Vol 69 (12) ◽  
pp. 1696-1700 ◽  
Author(s):  
A. A. Cunha ◽  
B. N. Porto ◽  
N. K. Nuñez ◽  
R. G. Souza ◽  
M. H. M. Vargas ◽  
...  
Keyword(s):  
Extracellular Dna ◽  
Pulmonary Response ◽  
Bronchoalveolar Fluid ◽  
Extracellular Dna Traps

Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus

2018 ◽  
Vol 141 (2) ◽  
pp. 571-585.e7 ◽  
Author(s):  
Valdirene S. Muniz ◽  
Juliana C. Silva ◽  
Yasmim A.V. Braga ◽  
Rossana C.N. Melo ◽  
Shigeharu Ueki ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Extracellular Dna ◽  
Extracellular Dna Traps

Paligenosis: Cellular Remodeling During Tissue Repair

2021 ◽  
Vol 84 (1) ◽  
Author(s):  
Jeffrey W. Brown ◽  
Charles J. Cho ◽  
Jason C. Mills
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Tissue Repair ◽  
Annual Review ◽  
Publication Date ◽  
Cell Plasticity ◽  
Evolutionarily Conserved ◽  
Single Cell Rna Sequencing ◽  
Multicellular Organisms ◽  
New Framework

Complex multicellular organisms have evolved specific mechanisms to replenish cells in homeostasis and during repair. Here, we discuss how emerging technologies (e.g., single-cell RNA sequencing) challenge the concept that tissue renewal is fueled by unidirectional differentiation from a resident stem cell. We now understand that cell plasticity, i.e., cells adaptively changing differentiation state or identity, is a central tissue renewal mechanism. For example, mature cells can access an evolutionarily conserved program (paligenosis) to reenter the cell cycle and regenerate damaged tissue. Most tissues lack dedicated stem cells and rely on plasticity to regenerate lost cells. Plasticity benefits multicellular organisms, yet it also carries risks. For one, when long-lived cells undergo paligenotic, cyclical proliferation and redifferentiation, they can accumulate and propagate acquired mutations that activate oncogenes and increase the potential for developing cancer. Lastly, we propose a new framework for classifying patterns of cell proliferation in homeostasis and regeneration, with stem cells representing just one of the diverse methods that adult tissues employ. Expected final online publication date for the Annual Review of Physiology, Volume 84 is February 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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