scholarly journals T Cell Memory in Infection, Cancer, and Autoimmunity

2022 ◽  
Vol 12 ◽  
Author(s):  
Vincenzo Barnaba
Keyword(s):  
T Cell ◽  
Immunological Memory ◽  
T Cell Memory ◽  
Cell Memory ◽  
Term Survival ◽  
Molecular Features ◽  
T Cell Suppression ◽  
Cell Suppression ◽  
Cell Effector

Long-term immunological memory represents a unique performance of the adaptive immunity selected during evolution to support long-term survival of species in vertebrates, through protection against dangerous “invaders”, namely, infectious agents or unwanted (e.g., tumor) cells. The balance between the development of T cell memory and various mechanisms of immunoregulation (namely, T cell effector exhaustion and regulatory T cell suppression) dictates the fate in providing protection or not in different conditions, such as (acute or chronic) infection, vaccination, cancer, and autoimmunity. Here, these different environments are taken in consideration to outline the up-to-date cellular and molecular features regulating the development or damping of immunological memory and to delineate therapeutic strategies capable to improve or control it, in order to address pathological contexts, such as infection, tumor, and autoimmunity.

scholarly journals LONG TERM SURVIVAL OF CONCORDANT XENOGRAFT BY MACROPHAGE DEPLETION AND T CELL SUPPRESSION.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S382
Author(s):  
Nozomi Koyamada ◽  
Jun Takayama ◽  
Takayuki Abe ◽  
Nobuhiro Ohkohchi ◽  
Susumu Satomi
Keyword(s):  
T Cell ◽  
Term Survival ◽  
Long Term Survival ◽  
Macrophage Depletion ◽  
T Cell Suppression ◽  
Cell Suppression

Unconventional cytokine profiles and development of T cell memory in long-term survivors after cancer vaccination

2009 ◽  
Vol 58 (10) ◽  
pp. 1609-1626 ◽  
Author(s):  
Jon Amund Kyte ◽  
Sissel Trachsel ◽  
Bente Risberg ◽  
Per thor Straten ◽  
Kari Lislerud ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Memory ◽  
Cell Memory ◽  
Cancer Vaccination ◽  
Cytokine Profiles ◽  
After Cancer ◽  
Long Term Survivors

scholarly journals Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells.

1996 ◽  
Vol 183 (5) ◽  
pp. 2153-2163 ◽  
Author(s):  
F Di Rosa ◽  
P Matzinger
Keyword(s):  
T Cell ◽  
B Cells ◽  
Cd8 T Cell ◽  
T Cell Memory ◽  
Cellular Interactions ◽  
Cell Memory ◽  
Long Term Retention ◽  
Cd8 T Cell Memory ◽  
Antigen Presenting

The cellular basis of immunological memory has been a debated issue. It is not clear whether CD8 T cell memory is maintained by long-lived cells or by specific or nonspecific restimulation. Here, we have approached the question from a different angle, asking whether the cellular interactions that are required to maintain memory are the same as those necessary to activate cytotoxic T lymphocytes. We studied the CD8 memory response to the male antigen H-Y in mice deficient in CD4 cells, or B cells and found that memory in these mice was virtually unimpaired. These results suggest that CD8 memory is CD4 independent and that there is no requirement for long term retention of immune complexes on follicular dendritic cells, nor for B cells as antigen-presenting cells.

scholarly journals Long term persistence of T cell memory to HBsAg after hepatitis B vaccination

2004 ◽  
Vol 10 (2) ◽  
pp. 260 ◽  
Author(s):  
Ru-Xiang Wang ◽  
Greet J. Boland ◽  
Jan van Hattum ◽  
Gijsbert C. de Gast
Keyword(s):  
T Cell ◽  
Hepatitis B ◽  
T Cell Memory ◽  
Hepatitis B Vaccination ◽  
Cell Memory

scholarly journals Quantitative Analysis of Long-Term Virus-Specific CD8+-T-Cell Memory in Mice Challenged with Unrelated Pathogens

2003 ◽  
Vol 77 (14) ◽  
pp. 7756-7763 ◽  
Author(s):  
Haiyan Liu ◽  
Samita Andreansky ◽  
Gabriela Diaz ◽  
Stephen J. Turner ◽  
Dominik Wodarz ◽  
...  
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
Influenza A Virus ◽  
Influenza A ◽  
Respiratory Infections ◽  
T Cell Memory ◽  
Cell Memory ◽  
Immune Effector ◽  
Memory Cytotoxic T Lymphocytes

ABSTRACT The consequences for the long-term maintenance of virus-specific CD8+-T-cell memory have been analyzed experimentally for sequential respiratory infections with readily eliminated (influenza virus) and persistent (gammaherpesvirus 68 [γHV68]) pathogens. Sampling a broad range of tissue sites established that the numbers of CD8+ T cells specific for the prominent influenza virus DbNP366 epitope were reduced by about half in mice that had been challenged 100 days previously with γHV68, though the prior presence of a large CD8+ DbNP366 + population caused no selective defect in the γHV68-specific CD8+ Kbp79+ response. Conversely, mice that had been primed and boosted to generate substantial γHV68-specific CD8+ Dbp56+ populations did not show any decrease in prevalence for this set of CD8+ memory cytotoxic T lymphocytes (CTL) at 200 days after respiratory exposure to an influenza A virus. However, in both experiments, the total magnitude of the CD8+-T-cell pool was significantly diminished in those that had been infected with γHV68 and the influenza A virus. The broader implications of these findings, especially under conditions of repeated exposure to unrelated pathogens, are explored with a mathematical model which emphasizes that the immune effector and memory “phenome” is a function of the overall infection experience of the individual.

scholarly journals Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with Schistosoma haematobium

2018 ◽  
Vol 8 ◽  
Author(s):  
Kirsten E. Lyke ◽  
Abdoulaye Dabo ◽  
Charles Arama ◽  
Issa Diarra ◽  
Christopher V. Plowe ◽  
...  
Keyword(s):  
T Cell ◽  
Schistosoma Haematobium ◽  
Cd4 T Cell ◽  
T Cell Memory ◽  
Cell Memory ◽  
Term Maintenance

Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus

2001 ◽  
Vol 31 (9) ◽  
pp. 2574-2582 ◽  
Author(s):  
Tobias Ostler ◽  
Tracy Hussell ◽  
Charles D. Surh ◽  
Peter Openshaw ◽  
Stephan Ehl
Keyword(s):  
Respiratory Syncytial Virus ◽  
T Cell ◽  
T Cell Memory ◽  
Cell Memory ◽  
Syncytial Virus

scholarly journals Long-term T cell memory to human leucocyte antigen-A2 supertype epitopes in humans vaccinated against smallpox

2007 ◽  
Vol 149 (2) ◽  
pp. 265-273 ◽  
Author(s):  
N. D. Ostrout ◽  
M. M. McHugh ◽  
D. J. Tisch ◽  
A. M. Moormann ◽  
V. Brusic ◽  
...  
Keyword(s):  
T Cell ◽  
Human Leucocyte Antigen ◽  
T Cell Memory ◽  
Cell Memory
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