scholarly journals SyNC, a Computationally Extensive and Realistic Neural Net to Identify Relative Impacts of Synaptopathy Mechanisms on Glutamatergic Neurons and Their Networks in Autism and Complex Neurological Disorders

2021 ◽  
Vol 15 ◽  
Author(s):  
Rounak Chatterjee ◽  
Janet L. Paluh ◽  
Souradeep Chowdhury ◽  
Soham Mondal ◽  
Arnab Raha ◽  
...  

Synaptic function and experience-dependent plasticity across multiple synapses are dependent on the types of neurons interacting as well as the intricate mechanisms that operate at the molecular level of the synapse. To understand the complexity of information processing at synaptic networks will rely in part on effective computational models. Such models should also evaluate disruptions to synaptic function by multiple mechanisms. By co-development of algorithms alongside hardware, real time analysis metrics can be co-prioritized along with biological complexity. The hippocampus is implicated in autism spectrum disorders (ASD) and within this region glutamatergic neurons constitute 90% of the neurons integral to the functioning of neuronal networks. Here we generate a computational model referred to as ASD interrogator (ASDint) and corresponding hardware to enable in silicon analysis of multiple ASD mechanisms affecting glutamatergic neuron synapses. The hardware architecture Synaptic Neuronal Circuit, SyNC, is a novel GPU accelerator or neural net, that extends discovery by acting as a biologically relevant realistic neuron synapse in real time. Co-developed ASDint and SyNC expand spiking neural network models of plasticity to comparative analysis of retrograde messengers. The SyNC model is realized in an ASIC architecture, which enables the ability to compute increasingly complex scenarios without sacrificing area efficiency of the model. Here we apply the ASDint model to analyse neuronal circuitry dysfunctions associated with autism spectral disorder (ASD) synaptopathies and their effects on the synaptic learning parameter and demonstrate SyNC on an ideal ASDint scenario. Our work highlights the value of secondary pathways in regard to evaluating complex ASD synaptopathy mechanisms. By comparing the degree of variation in the synaptic learning parameter to the response obtained from simulations of the ideal scenario we determine the potency and time of the effect of a particular evaluated mechanism. Hence simulations of such scenarios in even a small neuronal network now allows us to identify relative impacts of changed parameters and their effect on synaptic function. Based on this, we can estimate the minimum fraction of a neuron exhibiting a particular dysfunction scenario required to lead to complete failure of a neural network to coordinate pre-synaptic and post-synaptic outputs.

2020 ◽  
Vol 10 (3) ◽  
pp. 766 ◽  
Author(s):  
Alec Wright ◽  
Eero-Pekka Damskägg ◽  
Lauri Juvela ◽  
Vesa Välimäki

This article investigates the use of deep neural networks for black-box modelling of audio distortion circuits, such as guitar amplifiers and distortion pedals. Both a feedforward network, based on the WaveNet model, and a recurrent neural network model are compared. To determine a suitable hyperparameter configuration for the WaveNet, models of three popular audio distortion pedals were created: the Ibanez Tube Screamer, the Boss DS-1, and the Electro-Harmonix Big Muff Pi. It is also shown that three minutes of audio data is sufficient for training the neural network models. Real-time implementations of the neural networks were used to measure their computational load. To further validate the results, models of two valve amplifiers, the Blackstar HT-5 Metal and the Mesa Boogie 5:50 Plus, were created, and subjective tests were conducted. The listening test results show that the models of the first amplifier could be identified as different from the reference, but the sound quality of the best models was judged to be excellent. In the case of the second guitar amplifier, many listeners were unable to hear the difference between the reference signal and the signals produced with the two largest neural network models. This study demonstrates that the neural network models can convincingly emulate highly nonlinear audio distortion circuits, whilst running in real-time, with some models requiring only a relatively small amount of processing power to run on a modern desktop computer.


Author(s):  
Peyman Mazidi ◽  
Mian Du ◽  
Lina Bertling Tjernberg ◽  
Miguel A Sanz Bobi

In this article, a parametric model for health condition monitoring of wind turbines is developed. The study is based on the assumption that a wind turbine’s health condition can be modeled through three features: rotor speed, gearbox temperature and generator winding temperature. At first, three neural network models are created to simulate normal behavior of each feature. Deviation signals are then defined and calculated as accumulated time-series of differences between neural network predictions and actual measurements. These cumulative signals carry health condition–related information. Next, through nonlinear regression technique, the signals are used to produce individual models for considered features, which mathematically have the form of proportional hazard models. Finally, they are combined to construct an overall parametric health condition model which partially represents health condition of the wind turbine. In addition, a dynamic threshold for the model is developed to facilitate and add more insight in performance monitoring aspect. The health condition monitoring of wind turbine model has capability of evaluating real-time and overall health condition of a wind turbine which can also be used with regard to maintenance in electricity generation in electric power systems. The model also has flexibility to overcome current challenges such as scalability and adaptability. The model is verified in illustrating changes in real-time and overall health condition with respect to considered anomalies by testing through actual and artificial data.


2020 ◽  
Vol 122 ◽  
pp. 338-363 ◽  
Author(s):  
Pablo Lanillos ◽  
Daniel Oliva ◽  
Anja Philippsen ◽  
Yuichi Yamashita ◽  
Yukie Nagai ◽  
...  

1995 ◽  
Vol 38 (4) ◽  
pp. 483-495 ◽  
Author(s):  
William Sims Bainbridge

This paper applies neural network technology, a standard approach in computer science that has been unaccountably ignored by sociologists, to the problem of developing rigorous sociological theories. A simulation program employing a “varimax” model of human learning and decision-making models central elements of the Stark-Bainbridge theory of religion. Individuals in a micro-society of 24 simulated people learn which categories of potential exchange partners to seek for each of four material rewards which in fact can be provided by other actors in the society. However, when they seek eternal life, they are unable to find suitable human exchange partners who can provide it to them, so they postulate the existence of supernatural exchange partners as substitutes. The explanation of how the particular neural net works, including reference to modulo arithmetic, introduces some aspects of this new technology to sociology, and this paper invites readers to explore the wide range of other neural net techniques that may be of value for social scientists


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