Volume Rendering of Angiographic Optical Coherence Tomography Angiography in Fovea Plana and Normal Foveal Pit

This paper aims to study adaptative vascular arrangements in idiopathic fovea plana with volume-rendered optical coherence tomography angiography (OCTA). A retrospective review of two cases of idiopathic fovea plana (mean age: 26.5 years) and two age-matched controls imaged with OCTA was conducted using spectral-domain OCTA (RTVue XR Avanti, Optovue, Inc., Fremont, CA) equipped with the AngioVue software. Both en face OCTA slabs and OCTA b scans were processed through Fiji software (http://fiji.sc; software version 2.0.0-rc-68/1.52e), and then extracted as image sequences for volume rendering reconstructions using the ImageVis3D volume rendering system (3.1.0 release). Eyes with idiopathic fovea plana demonstrated a regular superficial vascular plexus connecting to a single vascular monolayer representing the deeper vascular plexuses. At this location, several vertical short path connections were demonstrated, in contraposition with normal eyes where short path connections were infrequently observed. Advances in three-dimensional OCTA reconstruction increase the understanding of vascular connections and arrangement in retinal plexuses and possible anatomical variations that cannot be detected with conventional two-dimensional b scans.

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Longitudinal assessment of type 3 macular neovascularization using three-dimensional volume-rendering optical coherence tomography angiography

Canadian Journal of Ophthalmology ◽

10.1016/j.jcjo.2021.04.020 ◽

2021 ◽

Author(s):

Enrico Borrelli ◽

Leonardo Mastropasqua ◽

Eric Souied ◽

SriniVas Sadda ◽

Giovanna Vella ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Volume Rendering ◽

Optical Coherence Tomography Angiography ◽

Three Dimensional ◽

Optical Coherence ◽

Longitudinal Assessment ◽

Type 3

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Optical Coherence Tomography Angiography

Sriwijaya Journal of Ophthalmology ◽

10.37275/sjo.v2i1.20 ◽

2019 ◽

Vol 2 (1) ◽

pp. 46-54

Author(s):

Dita Mintardi ◽

AK Ansyori ◽

Ramzi Amin

Keyword(s):

Optical Coherence Tomography ◽

High Speed ◽

Optical Coherence Tomography Angiography ◽

Three Dimensional ◽

Imaging Method ◽

Optical Coherence ◽

Cross Sectional ◽

En Face ◽

Capillary Plexus ◽

Oct Imaging

Optical Coherence Tomography Angiography (OCTA) is a new high-resolution imaging method for visualizing retinal and choroidal circulation without any dye injection By detecting intravascular flow quickly when needed and being able to repeat images, as often as needed, without risk to patients, doctors will value OCTA as one of the most important applications of OCT imaging because of its ability to offer precise visualization of intravascular flow in the inner retina layer and outside, as well as the inner choroid. OCTA uses high-speed structural OCT imaging and provides three-dimensional data about microvascular structures, enabling visualization of the en face apart from the retinal capillary plexus and choriocapillaris, combined with co-registered en face and cross-sectional structural OCT. Although OCTA is a strong modality, it can have imaging artifacts and provide information that is inherently more complex than structural OCT alone. Successful interpretation of OCTA findings requires an understanding of how OCTA works, the relationship of various ocular pathologies to its angiographic features, and integrated assessment of angiographic and structural OCT data.

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Comparison of swept-source versus spectral-domain optical coherence tomography angiography for detection of macular neovascularization

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05229-6 ◽

2021 ◽

Author(s):

Anna Lentzsch ◽

Laura Schöllhorn ◽

Christel Schnorr ◽

Robert Siggel ◽

Sandra Liakopoulos

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Spectral Domain ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

En Face ◽

Increased Sensitivity ◽

Sensitivity Specificity ◽

Subretinal Hyperreflective Material

Abstract Purpose To compare swept-source (SS) versus spectral-domain (SD) optical coherence tomography angiography (OCTA) for the detection of macular neovascularization (MNV). Methods In this prospective cohort study, 72 eyes of 54 patients with subretinal hyperreflective material (SHRM) and/or pigment epithelial detachment (PED) on OCT possibly corresponding to MNV in at least one eye were included. OCTA scans were acquired using two devices, the PLEX Elite 9000 SS-OCTA and the Spectralis SD-OCTA. Fluorescein angiography (FA) was used as reference. Two graders independently evaluated en face OCTA images using a preset slab as well as a manually modified slab, followed by a combination of en face and cross-sectional OCTA. Results Sensitivity (specificity) for the automated slabs was 51.7% (93.0%) for SS-OCTA versus 58.6% (95.3%) for SD-OCTA. Manual modification of segmentation increased sensitivity to 79.3% for SS-OCTA but not for SD-OCTA (58.6%). The combination of en face OCTA with cross-sectional OCTA reached highest sensitivity values (SS-OCTA: 82.8%, SD-OCTA: 86.2%), and lowest number of cases with discrepancies between SS-OCTA and SD-OCTA (4.2%). Fleiss kappa as measure of concordance between FA, SS-OCTA, and SD-OCTA was 0.56 for the automated slabs, 0.60 for the manual slabs, and 0.73 (good agreement) for the combination of en face OCTA with cross-sectional OCTA. Concordance to FA was moderate for the automated slabs and good for manual slabs and combination with cross-sectional OCTA of both devices. Conclusion Both devices reached comparable results regarding the detection of MNV on OCTA. Sensitivity for MNV detection and agreement between devices was best when evaluating a combination of en face and cross-sectional OCTA.

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Retinal microcirculation abnormalities in patients with systemic sclerosis: an explorative optical coherence tomography angiography study

Rheumatology ◽

10.1093/rheumatology/keab258 ◽

2021 ◽

Author(s):

Adriano Carnevali ◽

Giuseppe Giannaccare ◽

Valentina Gatti ◽

Caterina Battaglia ◽

Giorgio Randazzo ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Flow Index ◽

Digital Ulcers ◽

Optical Coherence ◽

Vascular Abnormalities ◽

Capillary Plexus ◽

Retinal Microcirculation ◽

Vascular Plexuses

Abstract Objectives To investigate subclinical and clinical abnormalities in retinal and choroidal vascular plexuses in patients with SSc by means of optical coherence tomography angiography (OCT-A). Methods A total of 20 consecutive SSc patients were recruited and compared with 20 healthy subjects. Quantitative analysis of vessel density (VD), choriocapillaris plexus flow index (CCP-FI) and choroidal vascularity index were performed on OCT-A images in the superficial capillary plexus (SCP), deep capillary plexus (DCP) and CCP for all patients. Images were further reviewed by two independent readers for the assessment of qualitative abnormalities, including tortuosity, rarefaction areas, megacapillaries and macular-foveal capillaries. Results The DCP-VD in the whole scan and in the perifoveal, superior, inferior, nasal and temporal regions was significantly lower in the SSc group. The CCP-FI was significantly higher in SSc patients. When comparing SSc patients with and without digital ulcers, significantly decreased SCP-VD was demonstrated in the whole, perifoveal, superior, inferior, temporal and nasal regions. No difference in any of the OCT-A parameters was observed when comparing patients with and without interstitial lung disease. Qualitative analysis of OCT-A revealed at least one abnormality in 95% of patients. Conclusion We showed the ability of OCT-A to disclose early ocular vascular abnormalities in patients with SSc. Our results may represent a hypothesis-generating basis for exploring the potential role of OCT-A in diagnosis, monitoring and prognosis stratification in SSc.

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Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography

Clinical Ophthalmology ◽

10.2147/opth.s143018 ◽

2017 ◽

Vol Volume 11 ◽

pp. 1859-1869 ◽

Cited By ~ 3

Author(s):

Magdy Moussa ◽

Mahmoud Leila ◽

Hagar Khalid

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Choroidal Neovascular Membrane ◽

Swept Source ◽

En Face

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Characterizing Flow and Structure of Diabetic Retinal Neovascularization after Intravitreal Anti-VEGF Using Optical Coherence Tomography Angiography: A Pilot Study

Journal of Ophthalmology ◽

10.1155/2021/2942197 ◽

2021 ◽

Vol 2021 ◽

pp. 1-16

Author(s):

Christof Haensli ◽

Katrin Fasler ◽

Daniel Barthelmes ◽

Sandrine A. Zweifel

Keyword(s):

Optical Coherence Tomography ◽

Initial Treatment ◽

Measurement Method ◽

Optical Coherence Tomography Angiography ◽

Case Series ◽

Retinal Neovascularization ◽

Flow Density ◽

Optical Coherence ◽

En Face

Background/Aims. This study evaluates changes of flow and structure of diabetic retinal neovascularization (NV) treated with intravitreal antivascular endothelial growth factor (VEGF) agents using optical coherence tomography angiography (OCTA). With OCTA, retinal blood vessels are visualized at high resolution to separately look at flow and structure information without the need for dye injection. We introduce a new measurement method including and combining information of flow and structure. Methods. Retrospective observational case series. Patients with proliferative diabetic retinopathy (PDR) were treated with intravitreal antiVEGF injections. Retinal NV were repeatedly imaged using swept-source OCTA (Zeiss PlexElite 9000) at baseline, after initial treatment block with 3-4 monthly injections, and during a follow-up period of up to 51 weeks. Change of size and flow density of the structural and angio area of NV was assessed. Results. Nine NV in eight eyes of five patients were analyzed with a median follow-up time of 45 weeks. After the initial treatment block, en face structural area regressed, 18.7% ± 39.0% (95% CI 44.2–6.8%, p = 0.26 ), and en face angio area regressed, 51.9% ± 29.5% (95% CI 32.6 to 71.2%, p = 0.007 ). Flow density within the en face structural area decreased by 33% ± 19.2% (95% CI 20.5–45.5%, p = 0.0077 ). Flow density within the en face angio area decreased by mean 17.9% ± 25.2% (95% CI 1.4–34.4%, p = 0.066 ). In two fellow eyes, NV recurrence could be observed before the onset of vitreous bleeding in one. Conclusion. Our study introduces a new quantitative measurement for NV in PDR, combining structure and flow measurement. The structure area remained after treatment, while its flow density and angio area regressed. We propose this measurement method as a more physiological and possibly more comparable metrics.

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