Clustering the lexicon in the brain: a meta-analysis of the neurofunctional evidence on noun and verb processing

Objective: Acute anorexia nervosa (AN) leads to reduced gray (GM) and white matter (WM) volume in the brain, which however improves again upon restoration of weight. Yet little is known about the extent and clinical correlates of these brain changes, nor do we know much about the time-course and completeness of their recovery. Methods: We conducted a meta-analysis and a qualitative review of all magnetic resonance imaging studies involving volume analyses of the brain in both acute and recovered AN. Results: We identified structural neuroimaging studies with a total of 214 acute AN patients and 177 weight-recovered AN patients. In acute AN, GM was reduced by 5.6% and WM by 3.8% compared to healthy controls (HC). Short-term weight recovery 2–5 months after admission resulted in restitution of about half of the GM aberrations and almost full WM recovery. After 2–8 years of remission GM and WM were nearly normalized, and differences to HC (GM: –1.0%, WM: –0.7%) were no longer significant, although small residual changes could not be ruled out. In the qualitative review some studies found GM volume loss to be associated with cognitive deficits and clinical prognosis. Conclusions: GM and WM were strongly reduced in acute AN. The completeness of brain volume rehabilitation remained equivocal.

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Using brain stimulation to study noun and verb processing in primary progressive aphasia

PsycEXTRA Dataset ◽

10.1037/e512592013-601 ◽

2011 ◽

Author(s):

E. Lacey ◽

B. Gordon ◽

A. Hillis

Keyword(s):

Brain Stimulation ◽

Primary Progressive Aphasia ◽

Progressive Aphasia ◽

Primary Progressive ◽

Verb Processing ◽

Noun And Verb Processing

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The Auditory Brainstem Implant

The Oxford Handbook of the Auditory Brainstem ◽

10.1093/oxfordhb/9780190849061.013.28 ◽

2019 ◽

pp. 758-770

Author(s):

Robert V. Shannon

Keyword(s):

Surgical Technique ◽

Cochlear Nucleus ◽

Meta Analysis ◽

Auditory Brainstem ◽

Auditory Information ◽

Speech Understanding ◽

Auditory Neurons ◽

Auditory Brainstem Implant ◽

The Brain ◽

Implanted Device

The auditory brainstem implant (ABI) is a surgically implanted device to electrically stimulate auditory neurons in the cochlear nucleus complex of the brainstem in humans to restore hearing sensations. The ABI is similar in function to a cochlear implant, but overall outcomes are poorer. However, recent applications of the ABI to new patient populations and improvements in surgical technique have led to significant improvements in outcomes. While the ABI provides hearing benefits to patients, the outcomes challenge our understanding of how the brain processes neural patterns of auditory information. The neural pattern of activation produced by an ABI is highly unnatural, yet some patients achieve high levels of speech understanding. Based on a meta-analysis of ABI surgeries and outcomes, a theory is proposed of a specialized sub-system of the cochlear nucleus that is critical for speech understanding.

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The Effect of Water-Based Therapy Compared to Land-Based Therapy on Balance and Gait Parameters of Patients with Stroke: A Systematic Review

European Neurology ◽

10.1159/000517377 ◽

2021 ◽

pp. 1-9

Author(s):

Nour Zughbor ◽

Aisha Alwahshi ◽

Rahaf Abdelrahman ◽

Zeina Elnekiti ◽

Hoda Elkareish ◽

...

Keyword(s):

Meta Analysis ◽

Berg Balance Scale ◽

Primary Outcome Measure ◽

Balance System ◽

Effect Of Water ◽

Gait Parameters ◽

Water Based ◽

Biodex Balance System ◽

Therapy Studies ◽

The Brain

Introduction: Stroke is defined as the lack of blood supply to the brain, leading to rapid loss of brain function presenting with impairments such as muscle weakness, spasticity, lack of coordination, and proprioception loss. Both hydrotherapy and land-based therapy aim to target these aspects in the process of rehabilitation. The study aims to determine the effectiveness of water-based therapy on balance and gait of patients with stroke compared to land-based therapy. Methods: Data for this review were extracted from databases such as CINAHL, OTseeker, Ovid, PEDro, and PubMed (MEDLINE) and other sources such as Google Scholar. PRISMA guidelines were followed to exclude irrelevant studies. Only randomized controlled trials (RCTs) were included, and methodological quality was assessed using the PEDro scale. A meta-analysis of extracted data was conducted. Results: A total of 16 relevant RCTs were included for the review (n = 412 participants). All RCTs investigated the effect of water-based therapy compared to land-based therapy on balance and gait of patients with stroke. Meta-analysis of studies that used the Berg Balance Scale (BBS) as a primary outcome measure favored land-based therapy. Studies that used the Good Balance System (GBS) and the Biodex Balance System (BioBS) to measure the changes in anteroposterior sway and mediolateral sway favored water-based therapy. The overall pooled effect favored land-based therapy in improving gait parameters. Conclusion: Findings from meta-analysis support the effectiveness of land-based therapy in the improvement of balance and gait parameters of patients with stroke. However, the evidence for water-based therapy continues to be limited, and higher quality studies are required to determine the effectiveness of water-based therapy on patients with stroke, particularly on balance and gait.

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Author response for "The changed functional status of the brain was involved in patients with poststroke aphasia: Coordinate‐based (activation likelihood estimation) meta‐analysis"

10.1002/brb3.1867/v2/response1 ◽

2020 ◽

Author(s):

Ying Du ◽

Yujun Lee ◽

Chuan He ◽

Lihan Peng ◽

Qian Yong ◽

...

Keyword(s):

Functional Status ◽

Meta Analysis ◽

Likelihood Estimation ◽

Author Response ◽

Activation Likelihood Estimation ◽

The Brain

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Diagnostic Accuracy of Neuroimaging to Delineate Diffuse Gliomas within the Brain: A Meta-Analysis

American Journal of Neuroradiology ◽

10.3174/ajnr.a5368 ◽

2017 ◽

Vol 38 (10) ◽

pp. 1884-1891 ◽

Cited By ~ 23

Author(s):

N. Verburg ◽

F.W.A. Hoefnagels ◽

F. Barkhof ◽

R. Boellaard ◽

S. Goldman ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Meta Analysis ◽

Diffuse Gliomas ◽

The Brain

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Graph Ricci Curvatures Reveal Disease-related Changes in Autism Spectrum Disorder

10.1101/2021.11.28.470231 ◽

2021 ◽

Author(s):

Pavithra Elumalai ◽

Yasharth Yadav ◽

Nitin Williams ◽

Emil Saucan ◽

Jürgen Jost ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Resting State ◽

Neurodevelopmental Disorders ◽

Data Exchange ◽

Meta Analysis ◽

Resting State Fmri ◽

Brain Regions ◽

Autism Spectrum ◽

Spectrum Disorder ◽

The Brain

Autism Spectrum Disorder (ASD) is a set of neurodevelopmental disorders that pose a significant global health burden. Measures from graph theory have been used to characterise ASD-related changes in resting-state fMRI functional connectivity networks (FCNs), but recently developed geometry-inspired measures have not been applied so far. In this study, we applied geometry-inspired graph Ricci curvatures to investigate ASD-related changes in resting-state fMRI FCNs. To do this, we applied Forman-Ricci and Ollivier-Ricci curvatures to compare networks of ASD and healthy controls (N = 1112) from the Autism Brain Imaging Data Exchange I (ABIDE-I) dataset. We performed these comparisons at the brain-wide level as well as at the level of individual brain regions, and further, determined the behavioral relevance of region-specific differences with Neurosynth meta-analysis decoding. We found brain-wide ASD-related differences for both Forman-Ricci and Ollivier-Ricci curvatures. For Forman-Ricci curvature, these differences were distributed across 83 of the 200 brain regions studied, and concentrated within the Default Mode, Somatomotor and Ventral Attention Network. Meta-analysis decoding identified the brain regions showing curvature differences as involved in social cognition, memory, language and movement. Notably, comparison with results from previous non-invasive stimulation (TMS/tDCS) experiments revealed that the set of brain regions showing curvature differences overlapped with the set of brain regions whose stimulation resulted in positive cognitive or behavioural outcomes in ASD patients. These results underscore the utility of geometry-inspired graph Ricci curvatures in characterising disease-related changes in ASD, and possibly, other neurodevelopmental disorders.

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Minor Physical Anomalies in Bipolar Disorder—A Meta-Analysis

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.598734 ◽

2021 ◽

Vol 12 ◽

Author(s):

Eszter Varga ◽

András Hajnal ◽

Alexandra Soós ◽

Péter Hegyi ◽

Dóra Kovács ◽

...

Keyword(s):

Bipolar Disorder ◽

Meta Analysis ◽

Bipolar Disorders ◽

Effect Sizes ◽

Inclusion Criteria ◽

Weighted Mean ◽

Quality Of Evidence ◽

Minor Physical Anomalies ◽

The Brain

Introduction: Minor physical anomalies (MPAs) may reflect basic neurobiological features underlying bipolar disorders (BPD), as they are sensitive physical indicators of morphogenetic failure of the brain. Despite several researches about the presence of MPAs in BPD, the results are still controversial.Objectives: The aim of the present meta-analysis was to assess the standardized weighted mean effect sizes of MPAs in BPD and to examine if MPAs may be found predominantly in the head and/or facial regions in BPD patients compared to controls (HC).Methods: Four studies, involving 155 patients with BPD, and 187 HC, were involved in the analysis after searching the literature. For the investigation of MPAs in the peripheral (MPA-P) and in the head and facial regions (MPA-CF), two studies involving 121 BPD patients, and 133 HC passed the inclusion criteria.Results: The number of the MPAs in the BPD group was significantly higher compared to HC. Another important finding of the present study is that BPD patients' MPA-P scores do not significantly differ from those of the HC. In contrast, BPD patients' MPA-CF scores were found to be significantly higher compared to HC subjects. It is important to note that there was a low number of eligible publications included, which caused higher heterogeneity.Conclusions: Low quality of evidence suggests that MPAs are more common in patients with BPD than in HC and the higher rate of MPAs is found predominantly in the head and facial regions.

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