scholarly journals Relationships Between Cardiovascular Autonomic Profile and Work Ability in Patients With Pure Autonomic Failure

2021 ◽  
Vol 15 ◽  
Author(s):  
Antonio R. Zamunér ◽  
Maura Minonzio ◽  
Dana Shiffer ◽  
Roberto Fornerone ◽  
Beatrice Cairo ◽  
...  
Keyword(s):  
Work Ability ◽  
Orthostatic Intolerance ◽  
Autonomic Failure ◽  
Low Frequency ◽  
Systolic Arterial Pressure ◽  
Pure Autonomic Failure ◽  
Work Ability Index ◽  
Work Activity ◽  
Symptom Intensity ◽  
System Degeneration

Pure autonomic failure (PAF) is a rare disorder belonging to the group of synucleinopathies, characterized by autonomic nervous system degeneration. Severe orthostatic intolerance with recurrent syncope while standing are the two most disabling manifestations. Symptoms may start at middle age, thus affecting people at their working age. The aims of this study were to evaluate the autonomic and work ability impairment of a group of PAF patients and assess the relationships between cardiovascular autonomic control and work ability in these patients. Eleven PAF patients (age 57.3 ± 6.7 years), engaged in work activity, participated in the study. They completed the Composite Autonomic Symptom Score (COMPASS-31, range 0 no symptom-100 maximum symptom intensity) and Work Ability questionnaires (Work Ability Index, WAI, range 7–49; higher values indicate better work ability and lower values indicating unsatisfactory or jeopardized work ability). Electrocardiogram, blood pressure and respiratory activity were continuously recorded for 10 min while supine and during 75° head-up tilt (HUT). Autoregressive spectral analysis of cardiac cycle length approximated as the time distance between two consecutive R-wave peaks (RR) and systolic arterial pressure (SAP) variabilities provided the power in the high frequency (HF, 0.15–0.40 Hz) and low frequency (LF, 0.04–0.15 Hz) bands of RR and SAP variabilities. Cardiac sympatho-vagal interaction was assessed by LF to HF ratio (LF/HF), while the LF power of SAP (LFSAP) quantified the vascular sympathetic modulation. Changes in cardiovascular autonomic indexes induced by HUT were calculated as the delta (Δ) between HUT and supine resting positions. Spearman correlation analysis was applied. PAF patients were characterized by a moderate autonomic dysfunction (COMPASS-31 total score 47.08 ± 20.2) and by a reduction of work ability (WAI 26.88 ± 10.72). Direct significant correlations were found between WAI and ΔLFRR (r = 0.66, p = 0.03) and ΔLF/HFRR (r = 0.70, p = 0.02). Results indicate that patients who were better able to modulate heart rate, as revealed by a greater cardiac sympathetic increase and/or vagal withdrawal during the orthostatic stimulus, were those who reported higher values of WAI. This finding could be relevant to propose new strategies in the occupational environment to prevent early retirement or to extend the working life of these patients.

scholarly journals Orthostatic Intolerance Is Independent of the Degree of Autonomic Cardiovascular Adaptation after 60 Days of Head-Down Bed Rest

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jiexin Liu ◽  
Yongzhi Li ◽  
Bart Verheyden ◽  
Zhanghuang Chen ◽  
Jingyu Wang ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Orthostatic Intolerance ◽  
Low Frequency ◽  
Systolic Arterial Pressure ◽  
Bed Rest ◽  
Progressive Increase ◽  
Tilt Test ◽  
Sinus Arrhythmia ◽  
Before And After ◽  
Low Frequency Power

Spaceflight and head-down bed rest (HDBR) can induce the orthostatic intolerance (OI); the mechanisms remain to be clarified. The aim of this study was to determine whether or not OI after HDBR relates to the degree of autonomic cardiovascular adaptation. Fourteen volunteers were enrolled for 60 days of HDBR. A head-up tilt test (HUTT) was performed before and after HDBR. Our data revealed that, in all nonfainters, there was a progressive increase in heart rate over the course of HDBR, which remained higher until 12 days of recovery. The mean arterial pressure gradually increased until day 56 of HDBR and returned to baseline after 12 days of recovery. Respiratory sinus arrhythmia and baroreflex sensitivity decreased during HDBR and remained suppressed until 12 days of recovery. Low-frequency power of systolic arterial pressure increased during HDBR and remained elevated during recovery. Three subjects fainted during the HUTT after HDBR, in which systemic vascular resistance did not increase and remained lower until syncope. None of the circulatory patterns significantly differed between the fainters and the nonfainters at any time point. In conclusion, our data indicate that the impaired orthostatic tolerance after HDBR could not be distinguished by estimation of normal hemodynamic and/or neurocardiac data.

scholarly journals Work Ability Assessment and Its Relationship with Cardiovascular Autonomic Profile in Postural Orthostatic Tachycardia Syndrome

2020 ◽  
Vol 17 (21) ◽  
pp. 7836
Author(s):  
Franca Barbic ◽  
Maura Minonzio ◽  
Beatrice Cairo ◽  
Dana Shiffer ◽  
Antonio Roberto Zamuner ◽  
...  
Keyword(s):  
Work Ability ◽  
Work Performance ◽  
Orthostatic Intolerance ◽  
Inverse Correlation ◽  
Postural Orthostatic Tachycardia Syndrome ◽  
Work Ability Index ◽  
Sympathetic Modulation ◽  
Work Ability Assessment ◽  
Head Up Tilt ◽  
Ability Index

Postural orthostatic tachycardia syndrome (POTS) negatively impacts quality of life. The excessive increase in cardiac sympathetic modulation during standing, which characterizes POTS patients, leads to many symptoms and signs of orthostatic intolerance. Little is known about the consequences of the disease on work performance and its relationship with individual autonomic profiles. Twenty-two POTS patients regularly engaged in working activity (20 females, age 36 ± 12 years) and 18 gender- and age-matched controls underwent a clinical evaluation and filled out the Work Ability Index (WAI) questionnaire. POTS patients completed the Composite Autonomic Symptom Score (COMPASS31) questionnaire, underwent continuous electrocardiogram, blood pressure and respiratory activity recordings while supine and during a 75° head-up tilt (HUT). A power spectrum analysis provided the index of cardiac sympatho-vagal balance (LF/HF). WAI scores were significantly reduced in POTS patients (29.84 ± 1.40) compared to controls (45.63 ± 0.53, p < 0.01). A significant inverse correlation was found between individual WAI and COMPASS31 scores (r = −0.46; p = 0.03), HUT increase in heart rate (r = −0.57; p = 0.01) and LF/HF (r = −0.55; p = 0.01). In POTS patients, the WAI scores were inversely correlated to the intensity of autonomic symptoms and to the excessive cardiac sympathetic activation induced by the gravitational stimulus.

Efficiency of droxydopa in pure autonomic failure

2010 ◽  
Vol 41 (01) ◽  
Author(s):  
M Knosalla ◽  
CA Haensch ◽  
J Wehe ◽  
H Lerch ◽  
J Weis ◽  
...  
Keyword(s):  
Autonomic Failure ◽  
Pure Autonomic Failure

IS HEALTH, MEASURED BY WORK ABILITY INDEX, AFFECTED BY 12-HOUR ROTATING SHIFT SCHEDULES?

2010 ◽  
Vol 27 (5) ◽  
pp. 1135-1148 ◽  
Author(s):  
Mei Yong ◽  
Michael Nasterlack ◽  
Rolf-Peter Pluto ◽  
Kathrin Elmerich ◽  
Dorothee Karl ◽  
...  
Keyword(s):  
Work Ability ◽  
Work Ability Index ◽  
Shift Schedules ◽  
Ability Index

scholarly journals Muscular Fitness and Work Ability among Physical Therapists

2021 ◽  
Vol 18 (4) ◽  
pp. 1722
Author(s):  
Yasmín Ezzatvar ◽  
Joaquín Calatayud ◽  
Lars Louis Andersen ◽  
Edgar Ramos Vieira ◽  
Rubén López-Bueno ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Grip Strength ◽  
Work Ability ◽  
Physical Therapists ◽  
Normative Values ◽  
Work Ability Index ◽  
Muscular Fitness ◽  
Physical Tests ◽  
Ability Index ◽  
Age And Sex

The Work Ability Index (WAI) is a validated and widely used tool in occupational research. However, normative values for physical therapists (PTs) by age and sex are lacking. Although the nature of PTs’ work is physically demanding, it is unknown whether muscular fitness is associated with their WAI. This study sought to provide reference WAI data for Spanish PTs and to evaluate the association between PTs’ muscular fitness and WAI. Data on WAI of 1005 PTs were collected using a questionnaire. A subgroup (n = 68) performed a battery of physical tests including grip strength, push-ups and back-extension endurance. Associations between muscular fitness and WAI were evaluated using logistic regression controlling for various confounders. PTs aged 50 years or older had lower WAI scores than their younger counterparts. PTs with high back-extension endurance scored 3.5 (95% CI) higher in the WAI than those with low endurance. No associations were found between grip strength or number of push-ups and WAI. Our findings seem to highlight the importance of muscular fitness in PTs, especially the back-extension endurance.

Skin nerve misfolded α-synuclein in pure autonomic failure and Parkinson disease

2015 ◽  
Vol 79 (2) ◽  
pp. 306-316 ◽  
Author(s):  
Vincenzo Donadio ◽  
Alex Incensi ◽  
Cristina Piccinini ◽  
Pietro Cortelli ◽  
Maria Pia Giannoccaro ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Autonomic Failure ◽  
Pure Autonomic Failure

scholarly journals Do work ability and life satisfaction matter for return to work? Predictive ability of the work ability index and life satisfaction questionnaire among women with long-term musculoskeletal pain

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mamunur Rashid ◽  
Marina Heiden ◽  
Annika Nilsson ◽  
Marja-Leena Kristofferzon
Keyword(s):  
Life Satisfaction ◽  
Back Pain ◽  
Sick Leave ◽  
Work Ability ◽  
Work Ability Index ◽  
Discriminative Ability ◽  
Satisfaction Questionnaire ◽  
Ability Index

Abstract Background Impaired work ability and reduced life satisfaction due to long-term musculoskeletal pain, particularly in neck, shoulders and back, are considered occupational health problems that can result in workers taking sick leave. The aim of the study was to determine whether work ability and life satisfaction predict return to work (RTW) among women with long-term neck/shoulder and/or back pain, and to assess the ability of the Work Ability Index (WAI) and the Life Satisfaction Questionnaire (LiSat-11) to discriminate between those who did RTW and those who did not RTW (NRTW). Methods This is a cohort study with 1-year follow-up. A survey was sent to 600 women receiving sick leave benefits from the Swedish Social Insurance Agency. In total, 208 women responded at baseline, and 141 at a 1-year follow-up. To identify whether work ability and life satisfaction predicted RTW, multiple logistic regression analyses were performed with and without adjustment for type of work and pain intensity. To assess the discriminative ability of the WAI and the LiSat-11 for women who did RTW and those who did NRTW, receiver operating characteristic curves were fitted. Results Work ability predicted RTW, and the results remained significant after adjusting for type of work and pain intensity (OR 1.12, 95% CI: 1.04–1.22). Life satisfaction was not significant. The WAI at baseline adequately discriminated between RTW and NRTW after 1 year (Area under curve 0.78, 95% CI: 0.70–0.86), but the LiSat-11 did not. Conclusions This study supports a relationship between work ability and RTW among women on sick leave for long-term neck/shoulder and/or back pain. The results indicate that the WAI, but not the LiSat-11, can discriminate between RTW and NRTW in the population under study. Although the discriminative ability of the WAI needs to be verified in new samples before it can be recommended for use in rehabilitation settings, we suggest that healthcare professionals consider how women perceive their work ability in order to better support them in their RTW.

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